{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:07:14Z","timestamp":1789373234439,"version":"build-2803163510"},"reference-count":52,"publisher":"The Korean Society of Applied Pharmacology","issue":"5","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400317"],"award-info":[{"award-number":["82400317"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Henan Cardiovascular Disease Center","award":["2023-FZX21"],"award-info":[{"award-number":["2023-FZX21"]}]},{"name":"Henan Provincial Medical Science and Technology Tackling Program","award":["LHGJ20210098"],"award-info":[{"award-number":["LHGJ20210098"]}]}],"content-domain":{"domain":["www.biomolther.org"],"crossmark-restriction":true},"short-container-title":["Biomol Ther (Seoul)"],"published-print":{"date-parts":[[2026,9,1]]},"DOI":"10.4062\/biomolther.2026.044","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:31:43Z","timestamp":1788244303000},"page":"1148-1162","update-policy":"https:\/\/doi.org\/10.4062\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of ATOH8 in Mitigating Cardiac Fibrosis in Heart Failure via Inhibition of the Transcriptional Repression of Smad7 by RUNX2"],"prefix":"10.4062","volume":"34","author":[{"given":"Chong","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yapan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyingjie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanyu","family":"Gao","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Coronary Heart Disease Control & Prevention, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yachen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"corresponding-author","vocabulary":"crossref"}]},{"given":"Zhuowang","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"corresponding-author","vocabulary":"crossref"}]}],"member":"2506","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-018-0449-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-013-1155-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-021-00354-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-015-1368-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023005"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2021.110066"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/biology11010136"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.136358"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076549"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(24)00215-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2020.01.001"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-03211-8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.021"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-014-1299-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2824"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-020-1533-0"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2443.2001.00476.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64498-z"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-015-0121-2"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI94753"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.04.021"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1349-6"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.7.1056"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28735"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15281"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-025-00712-y"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002430"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.add4222"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aay4430"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-024-04268-1"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700482R"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318159"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01569-x"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.116000"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-021-04219-w"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad1059"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040875"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.06.010"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.058655"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvae210"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25434"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-014-1305-z"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-017-0634-1"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8503"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjaa050"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-020-00106-0"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.05448-11"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010945"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167473"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1106-2"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1316"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.055727"}],"container-title":["Biomolecules & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pdf.medrang.co.kr\/BT2\/2026\/034\/BT034-05-1148.pdf","content-type":"unspecified","content-version":"tdm","intended-application":"text-mining"},{"URL":"https:\/\/pdf.medrang.co.kr\/BT2\/2026\/034\/BT034-05-1148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:09:28Z","timestamp":1789369768000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2026.044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.4062\/biomolther.2026.044"],"URL":"https:\/\/doi.org\/10.4062\/biomolther.2026.044","relation":{},"ISSN":["1976-9148","2005-4483"],"issn-type":[{"value":"1976-9148","type":"print"},{"value":"2005-4483","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"assertion":[{"value":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2026.044","URL":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2026.044","name":"the_journal","label":"Biomolecules & Therapeutics","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2026-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":3,"name":"published","label":"Online First","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":4,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2026 The Korean Society of Applied Pharmacology","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}