{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:07:14Z","timestamp":1789373234515,"version":"build-2803163510"},"reference-count":48,"publisher":"The Korean Society of Applied Pharmacology","issue":"5","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1C1C1003563"],"award-info":[{"award-number":["2022R1C1C1003563"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2025-25437662"],"award-info":[{"award-number":["RS-2025-25437662"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2022R1C1C1003563"],"award-info":[{"award-number":["2022R1C1C1003563"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2025-25437662"],"award-info":[{"award-number":["RS-2025-25437662"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.biomolther.org"],"crossmark-restriction":true},"short-container-title":["Biomol Ther (Seoul)"],"published-print":{"date-parts":[[2026,9,1]]},"DOI":"10.4062\/biomolther.2026.046","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:31:43Z","timestamp":1788244303000},"page":"1136-1147","update-policy":"https:\/\/doi.org\/10.4062\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SIRT6 Mediates Sterol-Dependent Feedback Regulation of Cholesterol Biosynthetic Genes in Hepatocytes"],"prefix":"10.4062","volume":"34","author":[{"given":"Yeonsoo","family":"Kim","sequence":"first","affiliation":[{"name":"College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye Eun","family":"Cho","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeokjin","family":"Lim","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunseo","family":"Park","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonghwan","family":"Hwang","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"corresponding-author","vocabulary":"crossref"}]}],"member":"2506","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410302200"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.107984"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.129358"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.115878"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.08.006"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.65044"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30333"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2318822121"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30681-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.12.022"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.11.014"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12006"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.728469"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.788562"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1065-0"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2015.11.008"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M072454"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01270"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.837544"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041253"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.10.052"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.06.009"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2024.251"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00372-7"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2018578117"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-025-01313-7"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3390\/cimb46030151"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0190-7"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.014"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1038\/nature06736"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.16.9367"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0306-9"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00037-4"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M093229"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.06.003"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81304-5"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-081820-101010"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00822-5"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.7150\/thno.49770"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.01.001"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M039339"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.777131"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-017-0464-z"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.16.9329"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020774"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166815"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2022.10.004"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.12.041"}],"container-title":["Biomolecules &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pdf.medrang.co.kr\/BT2\/2026\/034\/BT034-05-1136.pdf","content-type":"unspecified","content-version":"tdm","intended-application":"text-mining"},{"URL":"https:\/\/pdf.medrang.co.kr\/BT2\/2026\/034\/BT034-05-1136.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:09:27Z","timestamp":1789369767000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2026.046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.4062\/biomolther.2026.046"],"URL":"https:\/\/doi.org\/10.4062\/biomolther.2026.046","relation":{},"ISSN":["1976-9148","2005-4483"],"issn-type":[{"value":"1976-9148","type":"print"},{"value":"2005-4483","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"assertion":[{"value":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2026.046","URL":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2026.046","name":"the_journal","label":"Biomolecules & Therapeutics","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2026-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-08","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":3,"name":"published","label":"Online First","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":4,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2026 The Korean Society of Applied Pharmacology","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}