{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:05:52Z","timestamp":1784689552794,"version":"3.55.0"},"reference-count":137,"publisher":"The Korean Society of Applied Pharmacology","issue":"4","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2025-00562636"],"award-info":[{"award-number":["RS-2025-00562636"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2025-00562636"],"award-info":[{"award-number":["RS-2025-00562636"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002649","name":"Yeungnam University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002649","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.biomolther.org"],"crossmark-restriction":true},"short-container-title":["Biomol Ther (Seoul)"],"published-print":{"date-parts":[[2026,7,1]]},"DOI":"10.4062\/biomolther.2026.100","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T08:37:25Z","timestamp":1782808645000},"page":"780-799","update-policy":"https:\/\/doi.org\/10.4062\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Leptin Signaling at the Crossroads of Obesity, Immunity, and Cancer: Mechanistic Insights and Therapeutic Implications"],"prefix":"10.4062","volume":"34","author":[{"given":"Gitima","family":"Deka","sequence":"first","affiliation":[{"name":"College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pil-Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea"},{"name":"Research Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2506","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.572113"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00340"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07529-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2021.08.006"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.45"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2023.2253989"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2016.01.002"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25158"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1530\/EC-20-0109"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.12.8090"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191593"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1911-8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11761"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.05.029"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21843"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12517"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2013.1789"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-06-0027"},{"key":"ref19","unstructured":"Chen, Y. C., Chien, C. Y., Hsu, C. C., Lee, C. H., Chou, Y. T., Shiah, S. G., Liu, S. Y., Yen, C. Y., Hsieh, A. C. T., Wabitsch, M. and Shieh, Y. S. (2021) Obesity-associated leptin promotes chemoresistance in colorectal cancer through YAP-dependent AXL upregulation. <i>Am. J. Cancer Res.<\/i> <b>11<\/b>, 4220-4240."},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgq276"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.4HI0517-210R"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1840"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.70"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665111003259"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2001152"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2004.00149.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.08.013"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1568524"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179210"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/568343"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2004.07.031"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2019.103994"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-14-0405"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-019-0095-y"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1038\/27376"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20051578"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-51406-y"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1913"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2010.05.003"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101322"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00062.2007"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2019.10381"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04804-6"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.10.027"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2018.9356"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0208-7"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-018-0309-z"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5530"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40571-9"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.4283"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.3393\/ac.2015.31.6.222"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1530\/EC-19-0442"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4228"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.0643"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.622468"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2009.41.3.155"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004185107"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24273"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(01)00678-5"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1186\/s40608-014-0033-1"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2016.3483"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2025.2460281"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-026-08528-0"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22062870"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1038\/29795"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105700"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.8.4018"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408995102"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2010.04.002"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.02.029"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.11.6820"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003050"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502178102"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343592"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-006-0181-y"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(02)00276-8"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304984200"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2018.03.007"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22546"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.03.236"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.08.004"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.3892\/or.2022.8377"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2017.03.001"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12860"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.10.015"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.10.014"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-012-9788-7"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115446"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22684"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2019.01.006"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.30.6.1499"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402996"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2321"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2008.05.011"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2009.00323.x"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.07.003"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.12.013"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.01.011"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.21.6.1285"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301158"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609798200"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0456"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2021.10.054"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5383.1683"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.165660"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2004.01.017"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00111"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.3.1341"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-442"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ady7904"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055249"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1004054"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02462-2"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2023.07.004"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-023-03533-0"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2025.102310"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-025-03342-y"},{"key":"ref118","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2015.1056409"},{"key":"ref119","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.11.001"},{"key":"ref120","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-023-10617-8"},{"key":"ref121","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0221-5"},{"key":"ref122","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05641-2"},{"key":"ref123","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-016-0446-4"},{"key":"ref124","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00057.2011"},{"key":"ref125","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604913"},{"key":"ref126","doi-asserted-by":"crossref","unstructured":"Xu, Y., Tan, M., Tian, X., Zhang, J., Zhang, J., Chen, J., Xu, W. and Sheng, H. (2020) Leptin receptor mediates the proliferation and glucose metabolism of pancreatic cancer cells via AKT pathway activation. <i>Mol. Med. Rep.<\/i> <b>21<\/b>, 945-952.","DOI":"10.3892\/mmr.2019.10855"},{"key":"ref127","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.322800"},{"key":"ref128","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20773"},{"key":"ref129","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074843"},{"key":"ref130","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.8.4593"},{"key":"ref131","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-018-1171-6"},{"key":"ref132","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13090"},{"key":"ref133","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.10.013"},{"key":"ref134","doi-asserted-by":"publisher","DOI":"10.1038\/372425a0"},{"key":"ref135","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.09.011"},{"key":"ref136","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.04941.x"},{"key":"ref137","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6606013"}],"container-title":["Biomolecules &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pdf.medrang.co.kr\/BT2\/2026\/034\/BT034-04-780.pdf","content-type":"unspecified","content-version":"tdm","intended-application":"text-mining"},{"URL":"https:\/\/pdf.medrang.co.kr\/BT2\/2026\/034\/BT034-04-780.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T02:52:23Z","timestamp":1784688743000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2026.100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":137,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7,1]]}},"alternative-id":["10.4062\/biomolther.2026.100"],"URL":"https:\/\/doi.org\/10.4062\/biomolther.2026.100","relation":{},"ISSN":["1976-9148","2005-4483"],"issn-type":[{"value":"1976-9148","type":"print"},{"value":"2005-4483","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]},"assertion":[{"value":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2026.100","URL":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2026.100","name":"the_journal","label":"Biomolecules & Therapeutics","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2026-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-28","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":3,"name":"published","label":"Online First","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":4,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2026 The Korean Society of Applied Pharmacology","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}