{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T10:49:30Z","timestamp":1747306170305},"reference-count":90,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mayo Clinic Proceedings"],"published-print":{"date-parts":[[2000,3]]},"DOI":"10.4065\/75.3.265","type":"journal-article","created":{"date-parts":[[2009,1,24]],"date-time":"2009-01-24T01:17:28Z","timestamp":1232759848000},"page":"265-272","source":"Crossref","is-referenced-by-count":27,"title":["von Hippel-Lindau Disease"],"prefix":"10.4065","volume":"75","author":[{"given":"Vicki","family":"Couch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noralane M.","family":"Lindor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela S.","family":"Karnes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia V.","family":"Michels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.4065\/75.3.265_bib1","series-title":"Mendelian Inheritance in Man: A Catalog of Human Genes and Genetic Disorders","author":"McKusick","year":"1998"},{"key":"10.4065\/75.3.265_bib2","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1148\/radiology.194.3.7862955","article-title":"von Hippel-Lindau disease: genetic, clinical, and imaging features [published correction appears in Radiology. 1995; 196:582]","volume":"194","author":"Choyke","year":"1995","journal-title":"Radiology"},{"key":"10.4065\/75.3.265_bib3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF01994821","article-title":"Uber eine sehr seltene Erkrankung der Netzhaut","volume":"59","author":"von Hippel","year":"1904","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.4065\/75.3.265_bib4","first-page":"193","article-title":"Zur Frage der Angiomatosis retinae und ihrer Him-complikation. Acta","volume":"4","author":"Lindau","year":"1927","journal-title":"Ophthalmol (Scand)"},{"key":"10.4065\/75.3.265_bib5","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0002-9343(64)90107-X","article-title":"Lindau's disease: review of the literature and study of a large kindred","volume":"36","author":"Melmon","year":"1964","journal-title":"Am J Med"},{"key":"10.4065\/75.3.265_bib6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/jmg.28.7.443","article-title":"von Hippel-Lindau disease: a genetic study","volume":"28","author":"Maher","year":"1991","journal-title":"J Med Genet"},{"key":"10.4065\/75.3.265_bib7","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/0140-6736(91)91705-Y","article-title":"Clustering of features of von Hippel-Lindau syndrome: evidence for a complex genetic locus","volume":"337","author":"Neumann","year":"1991","journal-title":"Lancet"},{"key":"10.4065\/75.3.265_bib8","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/0959-8049(94)00391-H","article-title":"von Hippel-Lindau disease","volume":"30A","author":"Maher","year":"1994","journal-title":"Eur J Cancer"},{"key":"10.4065\/75.3.265_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005792-198901000-00001","article-title":"von Hippel-Lindau disease affecting 43 members of a single kindred","volume":"68","author":"Lamiell","year":"1989","journal-title":"Medicine (Baltimore)"},{"key":"10.4065\/75.3.265_bib10","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1750-3639.1995.tb00592.x","article-title":"von Hippel-Lindau syndrome","volume":"5","author":"Neumann","year":"1995","journal-title":"Brain Pathol"},{"key":"10.4065\/75.3.265_bib11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1212\/WNL.41.1.41","article-title":"Central nervous system involvement in von Hippel-Lindau disease","volume":"41","author":"Filling-Katz","year":"1991","journal-title":"Neurology"},{"key":"10.4065\/75.3.265_bib12","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/jmg.27.5.311","article-title":"Statistical analysis of the two stage mutation model in von Hippel-Lindau disease, and in sporadic cerebellar haemangioblastoma and renal cell carcinoma","volume":"27","author":"Maher","year":"1990","journal-title":"J Med Genet"},{"key":"10.4065\/75.3.265_bib13","series-title":"The Genetic Basis of Human Cancer","first-page":"455","article-title":"Renal carcinoma","author":"Linehan","year":"1998"},{"key":"10.4065\/75.3.265_bib14","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00005792-199711000-00001","article-title":"von Hippel-Lindau disease","volume":"76","author":"Maher","year":"1997","journal-title":"Medicine (Baltimore)"},{"key":"10.4065\/75.3.265_bib15","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1136\/jnnp.55.10.898","article-title":"Central nervous system lesions in von Hippel-Lindau syndrome","volume":"55","author":"Neumann","year":"1992","journal-title":"J Neurol Newo-surg Psychiatry"},{"key":"10.4065\/75.3.265_bib16","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/0002-9343(94)90026-4","article-title":"von Hippel-Lindau disease: new strategies in early detection and treatment","volume":"97","author":"Karsdorp","year":"1994","journal-title":"Am J Med"},{"key":"10.4065\/75.3.265_bib17","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/00004728-198909000-00001","article-title":"Radiologie screening for von Hippel-Lindau disease: the role of Gd-DTPA enhanced MR imaging of the CNS","volume":"13","author":"Filling-Katz","year":"1989","journal-title":"J Comput Assist Tomogr"},{"key":"10.4065\/75.3.265_bib18","first-page":"220","article-title":"Basic criteria for clinical diagnosis and genetic counselling in von Hippel-Lindau syndrome","volume":"16","author":"Neumann","year":"1987","journal-title":"Vasa"},{"key":"10.4065\/75.3.265_bib19","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1093\/qjmed\/77.2.1151","article-title":"Clinical features and natural history of von Hippel-Lindau disease","volume":"77","author":"Maher","year":"1990","journal-title":"QJM"},{"key":"10.4065\/75.3.265_bib20","first-page":"133","article-title":"von Hippel-Lindau disease i n a Newfoundland kindred","volume":"134","author":"Green","year":"1986","journal-title":"CMAJ"},{"key":"10.4065\/75.3.265_bib21","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/eye.1991.133","article-title":"Ophthalmo-logical screening for von Hippel-Lindau disease","volume":"5","author":"Moore","year":"1991","journal-title":"Eye"},{"key":"10.4065\/75.3.265_bib22","first-page":"276","article-title":"Retinal angiomatosis: the ocular manifestations of von Hippel-Lindau disease","volume":"21","author":"Ridley","year":"1986","journal-title":"Can J Ophthalmol"},{"key":"10.4065\/75.3.265_bib23","first-page":"367","article-title":"von Hippel-Lindau disease: the recognition and treatment of early angiomatosis retinae and the use of cryosurgery as an adjunct to therapy","volume":"68","author":"Welch","year":"1970","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.4065\/75.3.265_bib24","first-page":"312","article-title":"von Hippel-Lindau disease: clinical review and molecular genetics","volume":"4","author":"Glenn","year":"1990","journal-title":"Probl Urol"},{"key":"10.4065\/75.3.265_bib25","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1001\/archinte.1976.03630070017007","article-title":"von Hippel-Lindau disease: clinical and pathological manifestations in nine families with 50 affected members","volume":"136","author":"Horton","year":"1976","journal-title":"Arch Intern Med"},{"key":"10.4065\/75.3.265_bib26","first-page":"22","article-title":"Characterization of the renal pathology of a familial form of renal cell carcinoma associated with von Hippel-Lindau disease: clinical and molecular genetic implications","volume":"153","author":"Poston","year":"1995","journal-title":"J Vrol"},{"key":"10.4065\/75.3.265_bib27","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/S0046-8177(88)80089-3","article-title":"Renal pathology in von Hippel-Lindau disease","volume":"19","author":"Solomon","year":"1988","journal-title":"Hum Pathol"},{"key":"10.4065\/75.3.265_bib28","first-page":"1","article-title":"Renal lesions and phcochromocytoma in von Hippel-Lindau disease","volume":"23","author":"Richard","year":"1994","journal-title":"Adv Nephrol Necker Hosp"},{"key":"10.4065\/75.3.265_bib29","first-page":"868","article-title":"Polycystic kidneys as the renal lesion in Lindau's disease","volume":"125","author":"Frimodt-Moller","year":"1981","journal-title":"J Ural"},{"key":"10.4065\/75.3.265_bib30","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/0002-9343(87)90062-3","article-title":"Renal cell carcinoma in von Hippel-Lindau syndrome","volume":"82","author":"Malek","year":"1987","journal-title":"Am J Med"},{"key":"10.4065\/75.3.265_bib31","first-page":"309","article-title":"Prognosis of von Hippel-Lindau syndrome","volume":"16","author":"Neumann","year":"1987","journal-title":"Vasa"},{"key":"10.4065\/75.3.265_bib32","doi-asserted-by":"crossref","first-page":"505","DOI":"10.2214\/ajr.139.3.505","article-title":"CT screening of the abdomen in von Hippel-Lindau disease","volume":"139","author":"Levine","year":"1982","journal-title":"AIR Am J Roentgenol"},{"key":"10.4065\/75.3.265_bib33","first-page":"910","article-title":"A plea for conservation of kidney in renal adenocarcinoma associated with von Hippel-Lindau disease","volume":"124","author":"Pearson","year":"1980","journal-title":"J Vrol"},{"key":"10.4065\/75.3.265_bib34","first-page":"852","article-title":"Progression and survival after renal-conserving surgery for renal cell carcinoma: experience in 104 patients and extended followup","volume":"144","author":"Morgan","year":"1990","journal-title":"J Vrol"},{"key":"10.4065\/75.3.265_bib35","first-page":"461","article-title":"Conservative renal surgery for renal cell carcinoma in von Hippel-Lindau's disease","volume":"149","author":"Frydenberg","year":"1993","journal-title":"J Vrol"},{"key":"10.4065\/75.3.265_bib36","first-page":"2010","article-title":"Prevalence of microscopic lesions in grossly normal renal parenchyma from patients with von Hippel-Lindau disease, sporadic renal cell carcinoma and no renal disease: clinical implications","volume":"154","author":"Walther","year":"1995","journal-title":"J Vrol"},{"key":"10.4065\/75.3.265_bib37","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1056\/NEJM199311183292103","article-title":"Pheochromocytomas, multiple endocrine neopiasia type 2, and von Hippel-Lindau disease [published correction appears in N Engl J Med. 1994; 331:1535]","volume":"329","author":"Neumann","year":"1993","journal-title":"N Engi J Med"},{"key":"10.4065\/75.3.265_bib38","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1148\/radiology.166.1.3336687","article-title":"Hippel-Lindau disease: MR imaging","volume":"166","author":"Sato","year":"1988","journal-title":"Radiology"},{"key":"10.4065\/75.3.265_bib39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/00005792-197905000-00001","article-title":"Familial pheochromo-cytoma, hypercalcemia, and von Hippel-Lindau disease: a ten year study of a large family","volume":"58","author":"Atuk","year":"1979","journal-title":"Medicine (Baltimore)"},{"key":"10.4065\/75.3.265_bib40","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1148\/radiology.158.1.3940403","article-title":"Adrenal masses differentiated by MR","volume":"158","author":"Reinig","year":"1986","journal-title":"Radiology"},{"key":"10.4065\/75.3.265_bib41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1148\/radiographics.11.1.1671719","article-title":"MR imaging and MIBG scinligraphy of pheochromocytomas and extraadrenal functioning paragangltomas","volume":"11","author":"van Gils","year":"1991","journal-title":"Radiographies"},{"key":"10.4065\/75.3.265_bib42","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0300-595X(85)80070-0","article-title":"Phaeochromocytoma","volume":"14","author":"Cryer","year":"1985","journal-title":"Clin Endocrinol Meiab"},{"key":"10.4065\/75.3.265_bib43","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/bja\/58.12.1453","article-title":"Phaeochromocytoma: diagnosis, preoperative preparation and anaesthetic management","volume":"58","author":"Hull","year":"1986","journal-title":"Br J Anaesth"},{"key":"10.4065\/75.3.265_bib44","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0016-5085(91)90026-H","article-title":"Pancreatic lesions in the von Hippel-Lindau syndrome","volume":"101","author":"Neumann","year":"1991","journal-title":"Gastroenterology"},{"key":"10.4065\/75.3.265_bib45","first-page":"280","article-title":"Pancreatic involvement in Hippel-Lindau disease","volume":"140","author":"Bickler","year":"1984","journal-title":"West J Med"},{"key":"10.4065\/75.3.265_bib46","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1148\/radiology.174.3.2305064","article-title":"von Hippel-Lindau disease; radiologie screening for visceral manifestations","volume":"174","author":"Choyke","year":"1990","journal-title":"Radiology"},{"key":"10.4065\/75.3.265_bib47","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.2214\/ajr.159.6.1442389","article-title":"The natural history of renal lesions in von Hippel-Lindau disease: a serial CT study in 28 patients","volume":"159","author":"Choyke","year":"1992","journal-title":"AJR Am J Roentgenol"},{"key":"10.4065\/75.3.265_bib48","first-page":"1062","article-title":"Bilateral clear cell papillary cystadenoma of the epididymides presenting as infertility: an early manifestation of von Hippel-Lindau's syndrome","volume":"133","author":"Wirten","year":"1985","journal-title":"J Vrol"},{"key":"10.4065\/75.3.265_bib49","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/0002-9378(90)91207-S","article-title":"Papillary cystadenoma of the broad ligament in von Hippel-Lindau disease","volume":"163","author":"Kom","year":"1990","journal-title":"Am J Obstet Gynecol"},{"key":"10.4065\/75.3.265_bib50","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1001\/jama.1997.03540420057030","article-title":"Endolymphatic sac tumors: a source of morbid hearing loss in von Hippel-Lindau disease","volume":"277","author":"Manski","year":"1997","journal-title":"JAMA"},{"key":"10.4065\/75.3.265_bib51","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1073\/pnas.88.7.2864","article-title":"Genetic flanking markers refine diagnostic criteria and provide insights into the genetics of von Hippel Lindau disease","volume":"88","author":"Seizinger","year":"1991","journal-title":"Proc Nail Acad Sei USA"},{"key":"10.4065\/75.3.265_bib52","first-page":"66","article-title":"Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: correlations with phenotype","volume":"5","author":"Chen","year":"1995","journal-title":"HumMutat"},{"key":"10.4065\/75.3.265_bib53","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s004390050206","article-title":"Mutations in the VHL tumor suppressor gene and associated lesions in families with von Hippel-Lindau disease from central Europe","volume":"98","author":"Glavac","year":"1996","journal-title":"Hum Genet"},{"key":"10.4065\/75.3.265_bib54","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1136\/jmg.33.4.328","article-title":"Phenotypic expression in von Hippel-Lindau disease: correlations with germline VHL gene mutations","volume":"33","author":"Maher","year":"1996","journal-title":"J Med Genet"},{"key":"10.4065\/75.3.265_bib55","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1073\/pnas.68.4.820","article-title":"Mutation and cancer: statistical study of retinoblastoma","volume":"68","author":"Knudson","year":"1971","journal-title":"Proc Natl Acad Sei U S A"},{"key":"10.4065\/75.3.265_bib56","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/BF03401807","article-title":"The molecular basis of von Hippel-Lindau disease","volume":"3","author":"Iliopoulos","year":"1997","journal-title":"Mol Med"},{"key":"10.4065\/75.3.265_bib57","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/BF00420947","article-title":"von Hippel-Lindau disease: identification of deletion mutations by pulsed-field gel electro-phoresis","volume":"92","author":"Yao","year":"1993","journal-title":"Hum Genet"},{"key":"10.4065\/75.3.265_bib58","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/jnci\/81.14.1097","article-title":"Specific genetic change in tumors associated with van Hippel-Lindau disease","volume":"81","author":"Tory","year":"1989","journal-title":"J Natl Cancer Insi"},{"key":"10.4065\/75.3.265_bib59","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.8493574","article-title":"Identification of the von Hippel-Lindau disease tumor suppressor gene","volume":"260","author":"Latif","year":"1993","journal-title":"Science"},{"key":"10.4065\/75.3.265_bib60","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/ng0594-85","article-title":"Mutations of the VHL tumour suppressor gene in renal carcinoma","volume":"7","author":"Gnarra","year":"1994","journal-title":"Nat Genet"},{"key":"10.4065\/75.3.265_bib61","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1093\/hmg\/5.5.639","article-title":"Expression of the von Hippel-Lindau disease tumour suppressor gene during human embryogenesis","volume":"5","author":"Richards","year":"1996","journal-title":"Hum Mol Genet"},{"key":"10.4065\/75.3.265_bib62","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/BF03401583","article-title":"Expression of the von Hippel-Lindau tumor suppressor gene, VHL, in human fetal kidney and during mouse embryogenesis","volume":"1","author":"Kessler","year":"1995","journal-title":"Mol Med"},{"key":"10.4065\/75.3.265_bib63","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1093\/hmg\/3.8.1303","article-title":"Identification of in-tragenic mutations in the von Hippel-Lindau disease tumour suppressor gene and correlation with disease phenotype","volume":"3","author":"Crossey","year":"1994","journal-title":"Hum Mol Genet"},{"key":"10.4065\/75.3.265_bib64","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/hmg\/3.4.595","article-title":"Detailed mapping of germline deletions of the von Hippel-Lindau disease tumour suppressor gene","volume":"3","author":"Richards","year":"1994","journal-title":"Hum Mol Genet"},{"key":"10.4065\/75.3.265_bib65","first-page":"1092","article-title":"Germ-line mutations in the von Hippel-Lindau tumor-suppressor gene arc similar to somatic von Hippel-Lindau aberrations in sporadic renal cell carcinoma [published correction appears in Am J Hum Genet. 1995:56:356]","volume":"55","author":"Whaley","year":"1994","journal-title":"Am J Hum Genet"},{"key":"10.4065\/75.3.265_bib66","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1007\/BF02346188","article-title":"Detection of a germline mutation and somatic homozygous loss of the von Hippel-Lindau tumor-suppressor gene in a family with a de novo mutation: a combined genetic study, including cytogenelics, PCR\/SSCP, FISH, and CGH","volume":"97","author":"Decker","year":"1996","journal-title":"Hum Genet"},{"key":"10.4065\/75.3.265_bib67","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/BF00223868","article-title":"von Hippel-Lindau (VHL) disease with pheochromocytoma in the Black Forest region of Germany: evidence for a founder effect","volume":"95","author":"Brauch","year":"1995","journal-title":"Hum Genet"},{"key":"10.4065\/75.3.265_bib68","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/hmg\/2.7.879","article-title":"Mapping the von Hippel-Lindau disease tumour suppressor gene: identification of germline deletions by pulsed field gel electrophoresis","volume":"2","author":"Richards","year":"1993","journal-title":"Hum Mol Genet"},{"key":"10.4065\/75.3.265_bib69","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/hmg\/3.7.1191","article-title":"A novel donor splice site mutation associated with two mRNAs in von Hippel-Lindau disease","volume":"3","author":"Kishida","year":"1994","journal-title":"Hum Mol Genet"},{"key":"10.4065\/75.3.265_bib70","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1093\/hmg\/3.8.1423","article-title":"A novel mutation in the von Hippel-Lindau gene","volume":"3","author":"Loeb","year":"1994","journal-title":"Hum Mol Genet"},{"key":"10.4065\/75.3.265_bib71","first-page":"703","article-title":"Results of mutation analyses of von Hippel-Lindau disease gene in Japanese patients: comparison with results in United Stales and United Kingdom [in Japanese]","volume":"41","author":"Shuin","year":"1995","journal-title":"Hinyokika Kiyo"},{"key":"10.4065\/75.3.265_bib72","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/(SICI)1098-1004(1996)8:4<348::AID-HUMU8>3.0.CO;2-3","article-title":"Germline mutations in the von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan","volume":"8","author":"Zbar","year":"1996","journal-title":"Hum Mutat"},{"key":"10.4065\/75.3.265_bib73","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nm0895-822","article-title":"Tumour suppression by the human von Hippel-Lindau gene product","volume":"1","author":"Iliopoulos","year":"1995","journal-title":"Nat Med"},{"key":"10.4065\/75.3.265_bib74","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0046-8177(97)90035-6","article-title":"Immuno-staining of the von Hippel-Lindau gene product in normal and neoplastic human tissues","volume":"28","author":"Corless","year":"1997","journal-title":"Hum Paikal"},{"key":"10.4065\/75.3.265_bib75","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1073\/pnas.93.5.1770","article-title":"Nuclear\/cyloplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density","volume":"93","author":"Lee","year":"1996","journal-title":"Proc Natl Acad Sei U S A"},{"key":"10.4065\/75.3.265_bib76","first-page":"231","article-title":"Expression pattern of the von Hippel-Lindau protein in human tissues","volume":"75","author":"Los","year":"1996","journal-title":"Lab Invest"},{"key":"10.4065\/75.3.265_bib77","doi-asserted-by":"crossref","first-page":"6459","DOI":"10.1073\/pnas.92.14.6459","article-title":"Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations","volume":"92","author":"Duan","year":"1995","journal-title":"Proc Natl Acad Sei US A"},{"key":"10.4065\/75.3.265_bib78","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1126\/science.7660130","article-title":"Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C","volume":"269","author":"Kibel","year":"1995","journal-title":"Science"},{"key":"10.4065\/75.3.265_bib79","first-page":"4544","article-title":"Cellular proteins that bind the von Hippel-Lindau disease gene product: mapping of binding domains and the effect of missense mutations","volume":"55","author":"Kishida","year":"1995","journal-title":"Cancer Res"},{"key":"10.4065\/75.3.265_bib80","first-page":"2881","article-title":"Identification of a novel protein (VB P-l) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product","volume":"56","author":"Tsuchiya","year":"1996","journal-title":"Cancer Res"},{"key":"10.4065\/75.3.265_bib81","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1126\/science.7660122","article-title":"Inhibition of transcription elongation by the VHL tumor suppressor protein","volume":"269","author":"Duan","year":"1995","journal-title":"Science"},{"key":"10.4065\/75.3.265_bib82","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1126\/science.7660129","article-title":"Elongin (SIII): a multisubunit regulator of elongation by RNA polymcrase II","volume":"269","author":"Aso","year":"1995","journal-title":"Science"},{"key":"10.4065\/75.3.265_bib83","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0165-4608(96)00296-8","article-title":"The von Hippel-Lindau tumor suppressor gene: a rare and intriguing disease opening new insight into basic mechanisms of carcinogenesis","volume":"93","author":"Decker","year":"1997","journal-title":"Cancer Genel Cytogenet"},{"key":"10.4065\/75.3.265_bib84","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF00666036","article-title":"Regulation of the expression of the VEGF\/VPS and its receptors: role in tumor angiogenesis","volume":"36","author":"Kolch","year":"1995","journal-title":"Breast Cancer Res Treat"},{"key":"10.4065\/75.3.265_bib85","first-page":"4233","article-title":"Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis","volume":"54","author":"Takahashi","year":"1994","journal-title":"Cancer Res"},{"key":"10.4065\/75.3.265_bib86","first-page":"1358","article-title":"Up-reguLation of vascular endothctial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangio-blastomas","volume":"55","author":"Wizigmann-Voos","year":"1995","journal-title":"Cancel Res"},{"key":"10.4065\/75.3.265_bib87","doi-asserted-by":"crossref","first-page":"19761","DOI":"10.1074\/jbc.270.34.19761","article-title":"Hypoxia-induced tran-scriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells","volume":"270","author":"Ikeda","year":"1995","journal-title":"J Biol Chem"},{"key":"10.4065\/75.3.265_bib88","doi-asserted-by":"crossref","first-page":"10589","DOI":"10.1073\/pnas.93.20.10589","article-title":"Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene","volume":"93","author":"Gnarra","year":"1996","journal-title":"Proc Natl Acad Sei USA"},{"key":"10.4065\/75.3.265_bib89","doi-asserted-by":"crossref","first-page":"10595","DOI":"10.1073\/pnas.93.20.10595","article-title":"Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein","volume":"93","author":"Iliopoulos","year":"1996","journal-title":"Proc Natl Acad Sei U S A"},{"key":"10.4065\/75.3.265_bib90","first-page":"2299","article-title":"Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein","volume":"56","author":"Siemeister","year":"1996","journal-title":"Cancer Res"}],"container-title":["Mayo Clinic Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619611650313?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619611650313?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T13:57:18Z","timestamp":1558101438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025619611650313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":90,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,3]]}},"alternative-id":["S0025619611650313"],"URL":"https:\/\/doi.org\/10.4065\/75.3.265","relation":{},"ISSN":["0025-6196"],"issn-type":[{"value":"0025-6196","type":"print"}],"subject":[],"published":{"date-parts":[[2000,3]]}}}