{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:27:55Z","timestamp":1787030875972,"version":"build-2736575974"},"reference-count":82,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mayo Clinic Proceedings"],"published-print":{"date-parts":[[2001,3]]},"DOI":"10.4065\/76.3.285","type":"journal-article","created":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T20:18:34Z","timestamp":1232741914000},"page":"285-293","source":"Crossref","is-referenced-by-count":18,"title":["Hereditary Red Blood Cell Disorders in Middle Eastern Patients"],"prefix":"10.4065","volume":"76","author":[{"given":"David P.","family":"Steensma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Hoyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virgil F.","family":"Fairbanks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.4065\/76.3.285_bib1","series-title":"A Syllabus of Human Hemoglobin Variants","author":"Huisman","year":"1996"},{"key":"10.4065\/76.3.285_bib2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3109\/03630269809113144","article-title":"The thalassemia repository (9th ed; part II)","volume":"22","year":"1998","journal-title":"Hemoglobin"},{"key":"10.4065\/76.3.285_bib3","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1056\/NEJM199101173240306","article-title":"Glucose-6-phosphate dehydrogenase deficiency","volume":"324","author":"Beutler","year":"1991","journal-title":"N Engl J Med"},{"key":"10.4065\/76.3.285_bib4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0268-960X(95)90022-5","article-title":"Hereditary red cell enzymopathies","volume":"9","author":"Arya","year":"1995","journal-title":"Blood Rev"},{"key":"10.4065\/76.3.285_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0308-2261(21)00207-1","article-title":"Diagnostic strategy in a suspected red cell enzymopathy","volume":"10","author":"Keitt","year":"1981","journal-title":"Clin Haematol"},{"key":"10.4065\/76.3.285_bib6","first-page":"375","article-title":"Prevention and control of haemoglobinopathies","volume":"73","author":"Angastiniotis","year":"1995","journal-title":"Bull World Health Organ"},{"key":"10.4065\/76.3.285_bib7","series-title":"Clinician's Handbook of Preventive Services: Put Prevention Into Practice","first-page":"183","author":"US Office of Disease Prevention and Health Promotion","year":"1998"},{"key":"10.4065\/76.3.285_bib8","first-page":"1193","article-title":"The periodic health examination","volume":"121","author":"Canadian Task Force on the Periodic Health Examination","year":"1979","journal-title":"Can Med Assoc J"},{"key":"10.4065\/76.3.285_bib9","series-title":"The Canadian Guide to Clinical Preventive Health Care","first-page":"205","article-title":"Screening for hemoglobinopathies in Canada","author":"Goldbloom","year":"1994"},{"key":"10.4065\/76.3.285_bib10","series-title":"Guidelines for Women's Health Care","author":"American College of Obstetricians and Gynecologists","year":"1996"},{"key":"10.4065\/76.3.285_bib11","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0020-7292(96)90113-7","article-title":"ACOG technical bulletin: hemoglobinopathies in pregnancy: No. 220\u2014February 1996 (replaces No. 185, October 1993)","volume":"53","author":"Committee on Technical Bulletins of the American College of Obstetricians and Gynecologists","year":"1996","journal-title":"Int J Gynaecol Obstet"},{"key":"10.4065\/76.3.285_bib12","series-title":"Guide to Clinical Preventive Services","first-page":"231","author":"US Preventive Services Task Force","year":"1996"},{"key":"10.4065\/76.3.285_bib13","series-title":"Age Charts for Periodic Health Examination","author":"American Academy of Family Physicians","year":"1994"},{"key":"10.4065\/76.3.285_bib14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0268-960X(87)90032-4","article-title":"Results of programmes for antenatal detection of thalassemia in reducing the incidence of the disorder","volume":"1","author":"Cao","year":"1987","journal-title":"Blood Rev"},{"key":"10.4065\/76.3.285_bib15","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2337\/diacare.22.2.368","article-title":"HbA1c determination in patients with hemoglobinopathies [letter]","volume":"22","author":"Schnedl","year":"1999","journal-title":"Diabetes Care"},{"key":"10.4065\/76.3.285_bib16","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1749-6632.1998.tb10482.x","article-title":"Global epidemiology of hemoglobin disorders","volume":"850","author":"Angastiniotis","year":"1998","journal-title":"Ann N Y Acad Sci"},{"key":"10.4065\/76.3.285_bib17","first-page":"45","article-title":"Hemoglobin variants in the Middle East","volume":"Vol 2","author":"Kamel","year":"1987"},{"key":"10.4065\/76.3.285_bib18","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1136\/jmg.33.3.212","article-title":"Genetic referrals of Middle Eastern origin in a Western city: inbreeding and disease profile","volume":"33","author":"Hoodfar","year":"1996","journal-title":"J Med Genet"},{"key":"10.4065\/76.3.285_bib19","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1136\/jmg.32.8.623","article-title":"Consanguinity among the Saudi Arabian population","volume":"32","author":"el-Hazmi","year":"1995","journal-title":"J Med Genet"},{"key":"10.4065\/76.3.285_bib20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1017\/S0021932000012256","article-title":"Genetic disease and culture patterns in Lebanon","volume":"11","author":"Basson","year":"1979","journal-title":"J Biosoc Sci"},{"key":"10.4065\/76.3.285_bib21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0035-9203(80)90236-9","article-title":"Relationship between meteorological changes and occurrence of painful sickle cell crises in Kuwait","volume":"74","author":"Ibrahim","year":"1980","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.4065\/76.3.285_bib22","first-page":"50","article-title":"Kuwait","volume":"Vol 7","year":"1974"},{"key":"10.4065\/76.3.285_bib23","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s001090050253","article-title":"Glucose-6-phosphate dehydrogenase deficiency and malaria","volume":"76","author":"Ruwende","year":"1998","journal-title":"J Mol Med"},{"key":"10.4065\/76.3.285_bib24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0140-6736(72)90676-9","article-title":"Glucose-6-phosphate dehydrogenase and malaria: greater resistance of females heterozygous for enzyme deficiency and of males with non-deficient variant","volume":"1","author":"Bienzle","year":"1972","journal-title":"Lancet"},{"key":"10.4065\/76.3.285_bib25","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-2141.1999.01130.x","article-title":"Red blood cell membrane disorders","volume":"104","author":"Tse","year":"1999","journal-title":"Br J Haematol"},{"key":"10.4065\/76.3.285_bib26","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1159\/000205861","article-title":"Haemoglobinopathies, thalassaemias and enzymopathies in Saudi Arabia: the present status","volume":"78","author":"el-Hazmi","year":"1987","journal-title":"Acta Haematol"},{"key":"10.4065\/76.3.285_bib27","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1073\/pnas.80.1.298","article-title":"Glucose-6-phosphate dehydrogenase deficiency inhibits in vitro growth of Plasmodium falciparum","volume":"80","author":"Roth","year":"1983","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.4065\/76.3.285_bib28","series-title":"Background Notes: United Arab Emirates","year":"1991"},{"key":"10.4065\/76.3.285_bib29","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1182\/blood.V95.11.3585","article-title":"Estimating the prevalence of pyruvate kinase deficiency from the gene frequency in the general white population","volume":"95","author":"Beutler","year":"2000","journal-title":"Blood"},{"key":"10.4065\/76.3.285_bib30","first-page":"80","article-title":"Pyruvate kinase (PK) deficiency in Jordan","volume":"78","author":"Karadsheh","year":"1993","journal-title":"Haematologica"},{"key":"10.4065\/76.3.285_bib31","series-title":"Hematology: Basic Principles and Practice","first-page":"561","article-title":"Red cell enzymopathies","author":"Prchal","year":"2000"},{"key":"10.4065\/76.3.285_bib32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000153599","article-title":"Frequency of glucose-6-phosphate dehydrogenase, pyruvate kinase and hexokinase deficiency in the Saudi population","volume":"36","author":"el-Hazmi","year":"1986","journal-title":"Hum Hered"},{"key":"10.4065\/76.3.285_bib33","first-page":"137","article-title":"The genetics of glucose-6-phosphate dehydrogenase deficiency","volume":"27","author":"Beutler","year":"1990","journal-title":"Semin Hematol"},{"key":"10.4065\/76.3.285_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1073\/pnas.48.1.9","article-title":"The normal human female as a mosaic of X-chromosome activity: studies using the gene for G-6-PD-deficiency as a marker","volume":"48","author":"Beutler","year":"1962","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1, pt 1","key":"10.4065\/76.3.285_bib35","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1542\/peds.104.1.68","article-title":"Neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient heterozygotes","volume":"104","author":"Kaplan","year":"1999","journal-title":"Pediatrics"},{"key":"10.4065\/76.3.285_bib36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0268-960X(96)90019-3","article-title":"G6PD: population genetics and clinical manifestations","volume":"10","author":"Beutler","year":"1996","journal-title":"Blood Rev"},{"key":"10.4065\/76.3.285_bib37","first-page":"1171","article-title":"Investigation of genetic polymorphic traits in Jews: a contribution to the study of population genetics","volume":"9","author":"Szeinberg","year":"1973","journal-title":"Isr J Med Sci"},{"key":"10.4065\/76.3.285_bib38","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1182\/blood.V25.4.486.486","article-title":"Glucose-6-phosphate dehydrogenase deficiency in Saudi Arabia: a survey","volume":"25","author":"Gelpi","year":"1965","journal-title":"Blood"},{"key":"10.4065\/76.3.285_bib39","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1006\/bcmd.1996.0008","article-title":"Hematologically important mutations: glucose-6-phosphate dehydrogenase","volume":"22","author":"Beutler","year":"1996","journal-title":"Blood Cells Mol Dis"},{"key":"10.4065\/76.3.285_bib40","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1001\/archinte.1967.00290210119011","article-title":"Anemia during acute infections: role of glucose-6-phosphate dehydrogenase deficiency in Negroes","volume":"119","author":"Mengel","year":"1967","journal-title":"Arch Intern Med"},{"key":"10.4065\/76.3.285_bib41","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1182\/blood.V84.11.3613.bloodjournal84113613","article-title":"G6PD deficiency","volume":"84","author":"Beutler","year":"1994","journal-title":"Blood"},{"key":"10.4065\/76.3.285_bib42","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1136\/jmg.8.4.462","article-title":"On the pathogenesis of favism","volume":"8","author":"Sartori","year":"1971","journal-title":"J Med Genet"},{"key":"10.4065\/76.3.285_bib43","series-title":"Blood: Textbook of Hematology","first-page":"503","article-title":"Heinz body hemolytic anemias","author":"Jandl","year":"1996"},{"key":"10.4065\/76.3.285_bib44","doi-asserted-by":"crossref","first-page":"817","DOI":"10.7326\/0003-4819-64-4-817","article-title":"Clinical spectrum of hemolytic anemia associated with glucose-6-phosphate dehydrogenase deficiency","volume":"64","author":"Burka","year":"1966","journal-title":"Ann Intern Med"},{"key":"10.4065\/76.3.285_bib45","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1056\/NEJM199112053252322","article-title":"Hemolysis from exposure to naphthalene mothballs [letter]","volume":"325","author":"Todisco","year":"1991","journal-title":"N Engl J Med"},{"key":"10.4065\/76.3.285_bib46","series-title":"The Sanford Guide to Antimicrobial Therapy, 1998","author":"Gilbert","year":"1998"},{"key":"10.4065\/76.3.285_bib47","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1159\/000206727","article-title":"Phenazopyridine-induced hemolytic anemia in a patient with G6PD deficiency [letter]","volume":"70","author":"Tishler","year":"1983","journal-title":"Acta Hematol"},{"key":"10.4065\/76.3.285_bib48","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1182\/blood.V14.2.103.103","article-title":"The hemolytic effect of primaquine and related compounds: a review","volume":"14","author":"Beutler","year":"1959","journal-title":"Blood"},{"issue":"suppl 2","key":"10.4065\/76.3.285_bib49","doi-asserted-by":"crossref","first-page":"S218","DOI":"10.1093\/clinids\/9.Supplement_2.S218","article-title":"Use of trimethoprim-sulfamethoxazole in a glucose-6-phosphate dehydrogenase-deficient population","volume":"9","author":"Markowitz","year":"1987","journal-title":"Rev Infect Dis"},{"key":"10.4065\/76.3.285_bib50","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1172\/JCI105786","article-title":"In vivo lability of glucose-6-phosphate dehydrogenase in GdA- and GdMediterranean deficiency","volume":"47","author":"Piomelli","year":"1968","journal-title":"J Clin Invest"},{"key":"10.4065\/76.3.285_bib51","first-page":"29","article-title":"Series of cases of splenomegaly in children with anemia and peculiar bone change","volume":"37","author":"Cooley","year":"1925","journal-title":"Trans Am Pediatr Soc"},{"key":"10.4065\/76.3.285_bib52","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1182\/blood.V55.3.511.511","article-title":"Mapping the alpha-globin genes in an Algerian HbH patient and his family","volume":"55","author":"Whitelaw","year":"1980","journal-title":"Blood"},{"key":"10.4065\/76.3.285_bib53","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1056\/NEJM198012113032402","article-title":"A new genetic basis for hemoglobin-H disease","volume":"303","author":"Pressley","year":"1980","journal-title":"N Engl J Med"},{"key":"10.4065\/76.3.285_bib54","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1056\/NEJM199907083410207","article-title":"The -thalassemias [published correction appears in N Engl J Med. 1999;341:1407]","volume":"341","author":"Olivieri","year":"1999","journal-title":"N Engl J Med"},{"key":"10.4065\/76.3.285_bib55","series-title":"The Molecular Basis of Blood Diseases","first-page":"157","article-title":"The thalassemias","author":"Weatherall","year":"1994"},{"key":"10.4065\/76.3.285_bib56","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/ajh.2830300403","article-title":"Red cell ferritin and iron overload in heterozygous beta-thalassemia","volume":"30","author":"Van der Weyden","year":"1989","journal-title":"Am J Hematol"},{"key":"10.4065\/76.3.285_bib57","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/ajcp\/111.5.676","article-title":"Usefulness of certain red blood cell indices in diagnosing and differentiating thalassemia trait from iron-deficiency anemia [published correction appears in Am J Clin Pathol. 1999;112:428]","volume":"111","author":"Eldibany","year":"1999","journal-title":"Am J Clin Pathol"},{"key":"10.4065\/76.3.285_bib58","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0268-960X(98)90014-5","article-title":"Severe thalassaemia intermedia: clinical problems in the absence of hypertransfusion","volume":"12","author":"Mohamed","year":"1998","journal-title":"Blood Rev"},{"key":"10.4065\/76.3.285_bib59","first-page":"239","article-title":"Geographical survey of beta S-globin gene haplotypes: evidence for an independent Asian origin of the sickle-cell mutation","volume":"39","author":"Kulozik","year":"1986","journal-title":"Am J Hum Genet"},{"key":"10.4065\/76.3.285_bib60","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3109\/03630268309038420","article-title":"Hemoglobinopathies in Israel","volume":"7","author":"Eliakim","year":"1983","journal-title":"Hemoglobin"},{"key":"10.4065\/76.3.285_bib61","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1136\/adc.56.3.187","article-title":"Sickle cell disease in Saudi Arabs in early childhood","volume":"56","author":"Perrine","year":"1981","journal-title":"Arch Dis Child"},{"key":"10.4065\/76.3.285_bib62","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1365-2141.1986.tb07572.x","article-title":"Sickle cell anaemia among Eti-Turks: haematological, clinical and genetic observations","volume":"64","author":"Aluoch","year":"1986","journal-title":"Br J Haematol"},{"key":"10.4065\/76.3.285_bib63","first-page":"186","article-title":"Sickle cell anemia in an American white boy of Greek ancestry","volume":"131","author":"Campbell","year":"1977","journal-title":"Am J Dis Child"},{"key":"10.4065\/76.3.285_bib64","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1136\/bmj.2.4934.301","article-title":"Compatibility of sickling with malaria","volume":"2","author":"Deliyannis","year":"1955","journal-title":"BMJ"},{"key":"10.4065\/76.3.285_bib65","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1542\/peds.63.2.242","article-title":"Sickle cell anemia in two White American children: essential laboratory criteria for diagnosis","volume":"63","author":"Noronha","year":"1979","journal-title":"Pediatrics"},{"key":"10.4065\/76.3.285_bib66","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3109\/03630269109027893","article-title":"The origin of the sickle mutation in Greece: evidence from beta S globin gene cluster polymorphisms","volume":"15","author":"Boussiou","year":"1991","journal-title":"Hemoglobin"},{"key":"10.4065\/76.3.285_bib67","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00043426-199021000-00009","article-title":"Clinical features of sickle cell disease in eastern Saudi Arab children","volume":"12","author":"el Mouzan","year":"1990","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"10.4065\/76.3.285_bib68","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S0022-3476(84)80950-6","article-title":"Splenic function in sickle cell disease in the Eastern Province of Saudi Arabia","volume":"104","author":"Al-Awamy","year":"1984","journal-title":"J Pediatr"},{"key":"10.4065\/76.3.285_bib69","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1365-2141.1980.tb07163.x","article-title":"Hb F synthesis in sickle cell anaemia: a comparison of Saudi Arab cases with those of African origin","volume":"45","author":"Wood","year":"1980","journal-title":"Br J Haematol"},{"key":"10.4065\/76.3.285_bib70","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1136\/jmg.16.6.428","article-title":"Heterogeneity of sickle cell anaemia in Arabs: review of cases with various amounts of fetal haemoglobin","volume":"16","author":"Kamel","year":"1979","journal-title":"J Med Genet"},{"key":"10.4065\/76.3.285_bib71","first-page":"427","article-title":"Raised Hb F levels in sickle cell disease are caused by a determinant linked to the beta globin gene cluster","volume":"251","author":"Kulozik","year":"1987","journal-title":"Prog Clin Biol Res"},{"key":"10.4065\/76.3.285_bib72","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/03630269409014144","article-title":"Hemoglobin variants in North Africa","volume":"18","author":"Chami","year":"1994","journal-title":"Hemoglobin"},{"key":"10.4065\/76.3.285_bib73","first-page":"526","article-title":"RBC surface pits in the sickle hemoglobinopathies","volume":"133","author":"Sills","year":"1979","journal-title":"Am J Dis Child"},{"key":"10.4065\/76.3.285_bib74","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1001\/archopht.1971.00990050430006","article-title":"Natural history of untreated proliferative sickle retinopathy","volume":"85","author":"Goldberg","year":"1971","journal-title":"Arch Ophthalmol"},{"key":"10.4065\/76.3.285_bib75","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1056\/NEJM199111213252104","article-title":"Sickle cell disease as a cause of osteonecrosis of the femoral head","volume":"325","author":"Milner","year":"1991","journal-title":"N Engl J Med"},{"key":"10.4065\/76.3.285_bib76","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/(SICI)1096-8652(199904)60:4<279::AID-AJH5>3.0.CO;2-2","article-title":"Hemoglobin S\/OArab: thirteen new cases and review of the literature","volume":"60","author":"Zimmerman","year":"1999","journal-title":"Am J Hematol"},{"key":"10.4065\/76.3.285_bib77","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1056\/NEJM199904013401307","article-title":"Management of sickle cell disease","volume":"340","author":"Steinberg","year":"1999","journal-title":"N Engl J Med"},{"key":"10.4065\/76.3.285_bib78","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1056\/NEJM198709243171301","article-title":"Sickle-cell trait as a risk factor for sudden death in physical training","volume":"317","author":"Kark","year":"1987","journal-title":"N Engl J Med"},{"key":"10.4065\/76.3.285_bib79","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1182\/blood.V89.5.1787","article-title":"Acute chest syndrome in sickle cell disease: clinical presentation and course","volume":"89","author":"Vichinsky","year":"1997","journal-title":"Blood"},{"key":"10.4065\/76.3.285_bib80","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJM199505183322001","article-title":"Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia","volume":"332","author":"Charache","year":"1995","journal-title":"N Engl J Med"},{"key":"10.4065\/76.3.285_bib81","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1600-0609.1991.tb00559.x","article-title":"Occurrence and characteristics of hereditary spherocytosis in Algeria","volume":"47","author":"Zerhouni","year":"1991","journal-title":"Eur J Haematol"},{"key":"10.4065\/76.3.285_bib82","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/ajmg.1320180309","article-title":"Hereditary pyropoikilocytosis: report of two cases from Saudi Arabia","volume":"18","author":"Mallouh","year":"1984","journal-title":"Am J Med Genet"}],"container-title":["Mayo Clinic Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619611628905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619611628905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T07:23:40Z","timestamp":1709969020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025619611628905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3]]},"references-count":82,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,3]]}},"alternative-id":["S0025619611628905"],"URL":"https:\/\/doi.org\/10.4065\/76.3.285","relation":{},"ISSN":["0025-6196"],"issn-type":[{"value":"0025-6196","type":"print"}],"subject":[],"published":{"date-parts":[[2001,3]]}}}