{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T02:07:34Z","timestamp":1785377254966,"version":"3.55.0"},"reference-count":11,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mayo Clinic Proceedings"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.4065\/79.9.1185","type":"journal-article","created":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T20:23:48Z","timestamp":1232742228000},"page":"1185-1191","source":"Crossref","is-referenced-by-count":6,"title":["Vestibular Toxicity Due to Inhaled Tobramycin in a Patient With Renal Insufficiency"],"prefix":"10.4065","volume":"79","author":[{"given":"Randall S.","family":"Edson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Brey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine L.","family":"Terrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet M.","family":"Thibert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.4065\/79.9.1185_bib1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJM199901073400104","article-title":"Intermittent administration of inhaled tobramycin in patients with cystic fibrosis","volume":"340","author":"Ramsey","year":"1999","journal-title":"N Engl J Med"},{"key":"10.4065\/79.9.1185_bib2","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1001\/archotol.1990.01870040046011","article-title":"The development of the Dizziness Handicap Inventory","volume":"116","author":"Jacobson","year":"1990","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.4065\/79.9.1185_bib3","series-title":"Aminoglycoside Ototoxicity","year":"1981"},{"key":"10.4065\/79.9.1185_bib4","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1128\/AAC.31.9.1383","article-title":"Univariate and multivariate analyses of risk factors predisposing to auditory toxicity in patients receiving aminoglycosides","volume":"31","author":"Gatell","year":"1987","journal-title":"Antimicrob Agents ChemoTher"},{"key":"10.4065\/79.9.1185_bib5","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1164\/ajrccm\/136.6.1445","article-title":"Quantitative deposition of aerosolized gentamicin in cystic fibrosis","volume":"136","author":"Ilowite","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"10.4065\/79.9.1185_bib6","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1164\/ajrccm\/147.5.1279","article-title":"Lung distribution and pharmacokinetics of aerosolized tobramycin","volume":"147","author":"Le Conte","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"10.4065\/79.9.1185_bib7","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1056\/NEJM199306173282403","article-title":"Efficacy of aerosolized tobramycin in patients with cystic fibrosis","volume":"328","author":"Ramsey","year":"1993","journal-title":"N Engl J Med"},{"issue":"2, pt 1","key":"10.4065\/79.9.1185_bib8","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1164\/ajrccm.162.2.9910086","article-title":"Tobramycin solution for inhalation reduces sputum Pseudomonas aeruginosa density in bronchiectasis","volume":"162","author":"Barker","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.4065\/79.9.1185_bib9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1086\/317524","article-title":"Adjunctive salvage therapy with inhaled aminoglycosides for patients with persistent smear-positive pulmonary tuberculosis","volume":"32","author":"Sacks","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.4065\/79.9.1185_bib10","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1592\/phco.23.4.543.32122","article-title":"Toxic serum trough concentrations after administration of nebulized tobramycin","volume":"23","author":"Kahler","year":"2003","journal-title":"Pharmacotherapy"},{"key":"10.4065\/79.9.1185_bib11","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/ppul.10185","article-title":"Acute renal failure in cystic fibrosis: association with inhaled tobramycin therapy","volume":"34","author":"Hoffmann","year":"2002","journal-title":"Pediatr Pulmonol"}],"container-title":["Mayo Clinic Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619611626037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619611626037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,22]],"date-time":"2018-12-22T03:25:05Z","timestamp":1545449105000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025619611626037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0025619611626037"],"URL":"https:\/\/doi.org\/10.4065\/79.9.1185","relation":{},"ISSN":["0025-6196"],"issn-type":[{"value":"0025-6196","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}