{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T12:53:07Z","timestamp":1774961587598,"version":"3.50.1"},"reference-count":98,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mayo Clinic Proceedings"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.4065\/80.3.379","type":"journal-article","created":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T20:26:10Z","timestamp":1232742370000},"page":"379-388","source":"Crossref","is-referenced-by-count":49,"title":["The Roles of Bone Mineral Density, Bone Turnover, and Other Properties in Reducing Fracture Risk During Antiresorptive Therapy"],"prefix":"10.4065","volume":"80","author":[{"given":"Solomon","family":"Epstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.4065\/80.3.379_bib1","first-page":"1","article-title":"Osteoporosis prevention, diagnosis, and therapy","volume":"17","year":"2000","journal-title":"NIH Consens Statement"},{"key":"10.4065\/80.3.379_bib2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1517\/14656566.1.2.225","article-title":"Bisphosphonates in osteoporosis: recent clinical experience","volume":"1","author":"McClung","year":"2000","journal-title":"Expert Opin Pharmacother"},{"key":"10.4065\/80.3.379_bib3","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1210\/er.2001-9002","article-title":"Meta-analyses of therapies for postmenopausal osteoporosis, IX: summary of meta-analyses of therapies for postmenopausal osteoporosis","volume":"23","author":"Cranney","year":"2002","journal-title":"Endocr Rev"},{"key":"10.4065\/80.3.379_bib4","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1185\/030079904125003269","article-title":"Putting evidence-based medicine into clinical practice: comparing anti-resorptive agents for the treatment of osteoporosis","volume":"20","author":"Wehren","year":"2004","journal-title":"Curr Med Res Opin"},{"issue":"suppl 5","key":"10.4065\/80.3.379_bib5","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s00198-003-1489-x","article-title":"Bone quality: where do we go from here?","volume":"14","author":"Bouxsein","year":"2003","journal-title":"Osteoporos Int"},{"issue":"5B","key":"10.4065\/80.3.379_bib6","doi-asserted-by":"crossref","first-page":"42S","DOI":"10.1016\/0002-9343(91)90246-T","article-title":"Use of bisphosphonates in the prevention of bone loss and fractures","volume":"91","author":"Parfitt","year":"1991","journal-title":"Am J Med"},{"key":"10.4065\/80.3.379_bib7","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1002\/jbmr.5650111021","article-title":"Markers of bone resorption predict hip fracture in elderly women: the EPIDOS Prospective Study","volume":"11","author":"Garnero","year":"1996","journal-title":"J Bone Miner Res"},{"key":"10.4065\/80.3.379_bib8","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1359\/JBMR.040512","article-title":"Change in bone turnover and hip, non-spine and vertebral fracture in alendronate-treated women: the fracture intervention trial","volume":"19","author":"Bauer","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.4065\/80.3.379_bib9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1385\/JCD:2:3:323","article-title":"Practical clinical application of biochemical markers of bone turnover: consensus of an expert panel","volume":"2","author":"Miller","year":"1999","journal-title":"J Clin Densitom"},{"key":"10.4065\/80.3.379_bib10","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1007\/s001980170020","article-title":"Six and twelve month changes in bone turnover are related to reduction in vertebral fracture risk during 3 years of raloxifene treatment in postmenopausal osteoporosis","volume":"12","author":"Bjarnason","year":"2001","journal-title":"Osteoporos Int"},{"key":"10.4065\/80.3.379_bib11","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1359\/jbmr.2003.18.6.1051","article-title":"Relationship of early changes in bone resorption to the reduction in fracture risk with risedronate","volume":"18","author":"Eastell","year":"2003","journal-title":"J Bone Miner Res"},{"key":"10.4065\/80.3.379_bib12","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1210\/jc.87.4.1586","article-title":"Changes in bone density and turnover explain the reductions in incidence of nonvertebral fractures that occur during treatment with antiresorptive agents","volume":"87","author":"Hochberg","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4065\/80.3.379_bib13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S8756-3282(01)00667-6","article-title":"Different effects of antiresorptive therapies on vertebral and nonvertebral fractures in postmenopausal osteoporosis","volume":"30","author":"Delmas","year":"2002","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial","volume":"288","author":"Rossouw","year":"2002","journal-title":"JAMA"},{"key":"10.4065\/80.3.379_bib15","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1359\/jbmr.2002.17.2.341","article-title":"Bone histomorphometric and biochemical marker results of a 2-year placebo-controlled trial of raloxifene in postmenopausal women","volume":"17","author":"Ott","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.4065\/80.3.379_bib16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s001980050010","article-title":"Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis","volume":"11","author":"Reginster","year":"2000","journal-title":"Osteoporos Int"},{"key":"10.4065\/80.3.379_bib17","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1001\/jama.282.14.1344","article-title":"Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial","volume":"282","author":"Harris","year":"1999","journal-title":"JAMA"},{"key":"10.4065\/80.3.379_bib18","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1001\/jama.282.7.637","article-title":"Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial [published correction appears in JAMA. 1999;282:2124]","volume":"282","author":"Ettinger","year":"1999","journal-title":"JAMA"},{"key":"10.4065\/80.3.379_bib19","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1359\/jbmr.2002.17.11.1988","article-title":"Two-year results of once-weekly administration of alendronate 70 mg for the treatment of postmenopausal osteoporosis","volume":"17","author":"Rizzoli","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.4065\/80.3.379_bib20","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1210\/jc.79.6.1693","article-title":"Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment","volume":"79","author":"Garnero","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"issue":"suppl 1","key":"10.4065\/80.3.379_bib21","first-page":"S92","article-title":"Alendronate reduces fracture risk in lowest bone turnover group [abstract]","volume":"34","author":"Bauer","year":"2004","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib22","author":"Hosking"},{"issue":"suppl 1","key":"10.4065\/80.3.379_bib23","first-page":"S45","article-title":"Normal bone histomorphometry and 3D microarchitecture after 10 years alendronate treatment of postmenopausal women","volume":"19","author":"Recker","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.4065\/80.3.379_bib24","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/jor.1100140113","article-title":"Effect of alendronate on fracture healing and bone remodeling in dogs","volume":"14","author":"Peter","year":"1996","journal-title":"J Orthop Res"},{"key":"10.4065\/80.3.379_bib25","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1056\/NEJMoa030897","article-title":"Ten years' experience with alendronate for osteoporosis in postmenopausal women","volume":"350","author":"Bone","year":"2004","journal-title":"N Engl J Med"},{"key":"10.4065\/80.3.379_bib26","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/(SICI)1096-8644(199604)99:4<585::AID-AJPA5>3.0.CO;2-T","article-title":"Dynamic bone remodeling in later Pleistocene fossil hominids","volume":"99","author":"Abbott","year":"1996","journal-title":"Am J Phys Anthropol"},{"issue":"suppl 5","key":"10.4065\/80.3.379_bib27","first-page":"12","article-title":"Remodeling and skeletal fragility","volume":"14","author":"Heaney","year":"2003","journal-title":"Osteoporos Int"},{"key":"10.4065\/80.3.379_bib28","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S8756-3282(03)00236-9","article-title":"Is the paradigm shifting?","volume":"33","author":"Heaney","year":"2003","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bone.2004.03.022","article-title":"What is the normal rate of bone remodeling?","volume":"35","author":"Parfitt","year":"2004","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib30","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/00041552-200307000-00007","article-title":"Renal bone disease: a new conceptual framework for the interpretation of bone histomorphometry","volume":"12","author":"Parfitt","year":"2003","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.4065\/80.3.379_bib31","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S8756-3282(01)00414-8","article-title":"Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles","volume":"28","author":"Mashiba","year":"2001","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib32","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1359\/jbmr.2000.15.4.613","article-title":"Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib","volume":"15","author":"Mashiba","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.4065\/80.3.379_bib33","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1359\/JBMR.040126","article-title":"Suppressed bone turnover by long-term bisphosphonate treatment accumulates microdamage but maintains intrinsic material properties in cortical bone of dog rib","volume":"19","author":"Komatsubara","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.4065\/80.3.379_bib34","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S8756-3282(01)00642-1","article-title":"Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progression","volume":"30","author":"Parfitt","year":"2002","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib35","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1359\/jbmr.2000.15.4.621","article-title":"True strength","volume":"15","author":"Weinstein","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.4065\/80.3.379_bib36","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1056\/NEJM200202283460902","article-title":"Bisphosphonates and osteoporosis","volume":"346","author":"Solomon","year":"2002","journal-title":"N Engl J Med"},{"issue":"suppl 3","key":"10.4065\/80.3.379_bib37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00198-002-1345-4","article-title":"Bone strength and its determinants","volume":"14","author":"Ammann","year":"2003","journal-title":"Osteoporos Int"},{"key":"10.4065\/80.3.379_bib38","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S8756-3282(96)00383-3","article-title":"Assessment of the strength of proximal femur in vitro: relationship to femoral bone mineral density and femoral geometry","volume":"20","author":"Cheng","year":"1997","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib39","series-title":"Osteoporosis: Etiology, Diagnosis, and Management","first-page":"93","article-title":"Biomechanics of fractures","author":"Hayes","year":"1995"},{"key":"10.4065\/80.3.379_bib40","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1172\/JCI116872","article-title":"The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates","volume":"92","author":"Balena","year":"1993","journal-title":"J Clin Invest"},{"key":"10.4065\/80.3.379_bib41","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF02672503","article-title":"Lifelong administration of high doses of ibandronate increases bone mass and maintains bone quality of lumbar vertebrae in rats","volume":"8","author":"Lalla","year":"1998","journal-title":"Osteoporos Int"},{"key":"10.4065\/80.3.379_bib42","first-page":"2200","article-title":"Effects of treatment with ibandronate on bone mass, architecture, biomechanical properties, and bone concentration of ibandronate in ovariectomized aged rats","volume":"29","author":"Bauss","year":"2002","journal-title":"J Rheumatol"},{"key":"10.4065\/80.3.379_bib43","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s001980050061","article-title":"How hip and whole-body bone mineral density predict hip fracture in elderly women: the EPIDOS Prospective Study","volume":"8","author":"Schott","year":"1998","journal-title":"Osteoporos Int"},{"key":"10.4065\/80.3.379_bib44","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1136\/bmj.312.7041.1254","article-title":"Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures","volume":"312","author":"Marshall","year":"1996","journal-title":"BMJ"},{"key":"10.4065\/80.3.379_bib45","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0149-2918(99)80022-8","article-title":"Diagnosis and management of osteoporosis in postmeopausal women: clinical guidelines","volume":"21","author":"Meunier","year":"1999","journal-title":"Clin Ther"},{"key":"10.4065\/80.3.379_bib46","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1210\/jc.85.1.231","article-title":"Antifracture efficacy of antiresorptive agents are related to changes in bone density","volume":"85","author":"Wasnich","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4065\/80.3.379_bib47","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0002-9343(01)01124-X","article-title":"Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs","volume":"112","author":"Cummings","year":"2002","journal-title":"Am J Med"},{"key":"10.4065\/80.3.379_bib48","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/1529-0131(199906)42:6<1246::AID-ANR22>3.0.CO;2-U","article-title":"Larger increases in bone mineral density during alendronate therapy are associated with a lower risk of new vertebral fractures in women with postmenopausal osteoporosis","volume":"42","author":"Hochberg","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.4065\/80.3.379_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1359\/jbmr.2002.17.1.1","article-title":"Relationships between bone mineral density and incident vertebral fracture risk with raloxifene therapy","volume":"17","author":"Sarkar","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.4065\/80.3.379_bib50","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1210\/jc.85.11.4118","article-title":"Fracture risk reduction with alendronate in women with osteoporosis: the Fracture Intervention Trial [published correction appears in J Clin Endocrinol Metab. 2001;86:938]","volume":"85","author":"Black","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4065\/80.3.379_bib51","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1046\/j.1532-5415.2002.50102.x","article-title":"Alendronate reduces the risk of multiple symptomatic fractures: results from the fracture intervention trial","volume":"50","author":"Levis","year":"2002","journal-title":"J Am Geriatr Soc"},{"key":"10.4065\/80.3.379_bib52","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1210\/jc.2002-020400","article-title":"Risedronate prevents new vertebral fractures in postmenopausal women at high risk","volume":"88","author":"Watts","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4065\/80.3.379_bib53","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/PL00004171","article-title":"Multinational, placebo-controlled, randomized trial of the effects of alendronate on bone density and fracture risk in postmenopausal women with low bone mass: results of the FOSIT study","volume":"9","author":"Pols","year":"1999","journal-title":"Osteoporos Int"},{"key":"10.4065\/80.3.379_bib54","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s001980200038","article-title":"The impact of bone turnover and bone-active agents on bone quality: focus on the hip","volume":"13","author":"Dempster","year":"2002","journal-title":"Osteoporos Int"},{"key":"10.4065\/80.3.379_bib55","series-title":"Osteoporosis","first-page":"294","article-title":"Cancellous bone architecture and bone strength","author":"Kleerekoper","year":"1987"},{"key":"10.4065\/80.3.379_bib56","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S8756-3282(02)00779-2","article-title":"Correlation of bone mineral density with strength and microstructural parameters of cortical bone in vitro","volume":"31","author":"Wachter","year":"2002","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib57","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s001980200000","article-title":"Biomechanics of bone: determinants of skeletal fragility and bone quality","volume":"13","author":"Turner","year":"2002","journal-title":"Osteoporos Int"},{"key":"10.4065\/80.3.379_bib58","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S8756-3282(00)00318-5","article-title":"A novel mechanism for induction of increased cortical porosity in cases of intracapsular hip fracture","volume":"27","author":"Bell","year":"2000","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib59","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1359\/jbmr.2003.18.2.385","article-title":"Architecture is one of the determinants of bone strength [letter]","volume":"18","author":"Borah","year":"2003","journal-title":"J Bone Miner Res"},{"key":"10.4065\/80.3.379_bib60","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1359\/jbmr.2002.17.7.1139","article-title":"Risedronate preserves trabecular architecture and increases bone strength in vertebra of ovariectomized minipigs as measured by three-dimensional microcomputed tomography","volume":"17","author":"Borah","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.4065\/80.3.379_bib61","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00223-002-2066-6","article-title":"Canine cancellous bone microarchitecture after one year of high-dose bisphosphonates","volume":"72","author":"Ding","year":"2003","journal-title":"Calcif Tissue Int"},{"key":"10.4065\/80.3.379_bib62","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1185\/030079904X20259","article-title":"Trabecular bone microarchitecture after alendronate treatment of osteoporotic women","volume":"21","author":"Recker","year":"2005","journal-title":"Curr Med Res Opin"},{"key":"10.4065\/80.3.379_bib63","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.bone.2003.12.013","article-title":"Risedronate preserves bone architecture in postmenopausal women with osteoporosis as measured by three-dimensional microcomputed tomography","volume":"34","author":"Borah","year":"2004","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib64","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S8756-3282(01)00485-9","article-title":"Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women","volume":"29","author":"Roschger","year":"2001","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib65","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1359\/jbmr.2002.17.11.2030","article-title":"The role of interstitial fluid flow in the remodeling response to fatigue loading","volume":"17","author":"Tami","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.4065\/80.3.379_bib66","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S8756-3282(01)00619-6","article-title":"Targeted and nontargeted remodeling","volume":"30","author":"Burr","year":"2002","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib67","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S8756-3282(01)00620-2","article-title":"Is all cortical bone remodeling initiated by microdamage?","volume":"30","author":"Martin","year":"2002","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib68","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S8756-3282(97)00200-7","article-title":"Trabecular bone volume and microdamage accumulation in the femoral heads of women with and without femoral neck fractures","volume":"21","author":"Mori","year":"1997","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib69","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S8756-3282(02)00975-4","article-title":"Effects of vertebral bone fragility and bone formation rate on the mineralization levels of cancellous bone from white females","volume":"32","author":"Ciarelli","year":"2003","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib70","series-title":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","first-page":"367","article-title":"Sclerosing bone disorders","author":"Whyte","year":"1999"},{"key":"10.4065\/80.3.379_bib71","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.4065\/80.3.379_bib72","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1126\/science.1090985","article-title":"Regulation of bone mass in mice by the lipoxygenase gene Alox15","volume":"303","author":"Klein","year":"2004","journal-title":"Science"},{"key":"10.4065\/80.3.379_bib73","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S8756-3282(97)00018-5","article-title":"Mineralization of cancellous bone after alendronate and sodium fluoride treatment: a quantitative backscattered electron imaging study on minipig ribs","volume":"20","author":"Roschger","year":"1997","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib74","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S8756-3282(00)00376-8","article-title":"Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women","volume":"27","author":"Boivin","year":"2000","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib75","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S8756-3282(02)00973-0","article-title":"Constant mineralization density distribution in cancellous human bone","volume":"32","author":"Roschger","year":"2003","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib76","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.bone.2003.08.004","article-title":"Tissue mineralization is increased following 1-year treatment with high doses of bisphosphonates in dogs","volume":"33","author":"Burr","year":"2003","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib77","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1080\/03008200290000934","article-title":"Changes in bone remodeling rate influence the degree of mineralization of bone","volume":"43","author":"Boivin","year":"2002","journal-title":"Connect Tissue Res"},{"key":"10.4065\/80.3.379_bib78","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S8756-3282(97)00170-1","article-title":"Bone mineral density reflects bone mass but also the degree of mineralization of bone: therapeutic implications","volume":"21","author":"Meunier","year":"1997","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib79","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.bone.2003.12.012","article-title":"The degree of mineralization is a determinant of bone strength: a study on human calcanei","volume":"34","author":"Follet","year":"2004","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib80","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S8756-3282(01)00702-5","article-title":"Predicting human vertebral bone strength by vertebral static histomorphometry","volume":"30","author":"Thomsen","year":"2002","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib81","first-page":"9","article-title":"Preclinical evidence of normal bone with alendronate","volume":"101","author":"Hayes","year":"1999","journal-title":"Int J Clin Pract Suppl"},{"key":"10.4065\/80.3.379_bib82","series-title":"Actonel [package insert]","year":"2004"},{"key":"10.4065\/80.3.379_bib83","series-title":"Fosamax [package insert]","year":"2004"},{"key":"10.4065\/80.3.379_bib84","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1385\/JCD:1:4:395","article-title":"Evidence-based management of patients with osteoporosis","volume":"1","author":"Guyatt","year":"1998","journal-title":"J Clin Densitom"},{"key":"10.4065\/80.3.379_bib85","series-title":"Evidence-Based Medicine: How to Practice and Teach EBM","first-page":"173","author":"Sackett","year":"2000"},{"key":"10.4065\/80.3.379_bib86","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s001980050221","article-title":"Trabecular bone architecture in the distal radius using magnetic resonance imaging in subjects with fractures of the proximal femur","volume":"10","author":"Majumdar","year":"1999","journal-title":"Osteoporos Int"},{"key":"10.4065\/80.3.379_bib87","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/BF02554913","article-title":"The role of three-dimensional trabecular microstructure in the pathogenesis of vertebral compression fractures","volume":"37","author":"Kleerekoper","year":"1985","journal-title":"Calcif Tissue Int"},{"key":"10.4065\/80.3.379_bib88","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1359\/jbmr.2000.15.1.32","article-title":"Variations in three-dimensional cancellous bone architecture of the proximal femur in female hip fractures and in controls","volume":"15","author":"Ciarelli","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.4065\/80.3.379_bib89","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.bone.2003.11.012","article-title":"Discrimination between cases of hip fracture and controls is improved by hip structural analysis compared to areal bone mineral density: an ex vivo study of the femoral neck","volume":"34","author":"Mayhew","year":"2004","journal-title":"Bone"},{"key":"10.4065\/80.3.379_bib90","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1359\/jbmr.2003.18.9.1657","article-title":"Reduced iliac cancellous osteocyte density in patients with osteoporotic vertebral fracture","volume":"18","author":"Qui","year":"2003","journal-title":"J Bone Miner Res"},{"key":"10.4065\/80.3.379_bib91","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1056\/NEJMoa022464","article-title":"Bone loss and bone size after menopause","volume":"349","author":"Ahlborg","year":"2003","journal-title":"N Engl J Med"},{"key":"10.4065\/80.3.379_bib92","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1445-5994.1992.tb02124.x","article-title":"Trabecular spacing in post-menopausal Australian women with and without vertebral fractures","volume":"22","author":"Moore","year":"1992","journal-title":"Aust N Z J Med"},{"key":"10.4065\/80.3.379_bib93","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2106\/00004623-199503000-00008","article-title":"Age-related reductions in the strength of the femur tested in a fall-loading configuration","volume":"77","author":"Courtney","year":"1995","journal-title":"J Bone Joint Surg Am"},{"key":"10.4065\/80.3.379_bib94","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF00310169","article-title":"Effects of loading rate on strength of the proximal femur [published correction appears in Calcif Tissue Int. 1994;55:402]","volume":"55","author":"Courtney","year":"1994","journal-title":"Calcif Tissue Int"},{"key":"10.4065\/80.3.379_bib95","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s002239900683","article-title":"Age-related changes in the biomechanical properties of human cancellous bone collagen: relationship to bone strength","volume":"65","author":"Bailey","year":"1999","journal-title":"Calcif Tissue Int"},{"key":"10.4065\/80.3.379_bib96","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s001980050179","article-title":"Fractal analysis of proximal femur radiographs: correlation with biomechanical properties and bone mineral density","volume":"9","author":"Lin","year":"1999","journal-title":"Osteoporos Int"},{"key":"10.4065\/80.3.379_bib97","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1136\/bmj.321.7256.255","article-title":"Which clinical studies provide the best evidence? the best RCT still trumps the best observational study [editorial]","volume":"321","author":"Barton","year":"2000","journal-title":"BMJ"},{"key":"10.4065\/80.3.379_bib98","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S8756-3282(02)00946-8","article-title":"Long-term efficacy of risedronate: a 5-year placebo-controlled clinical experience","volume":"32","author":"Sorensen","year":"2003","journal-title":"Bone"}],"container-title":["Mayo Clinic Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002561961161611X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002561961161611X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,22]],"date-time":"2018-12-22T03:21:32Z","timestamp":1545448892000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002561961161611X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":98,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S002561961161611X"],"URL":"https:\/\/doi.org\/10.4065\/80.3.379","relation":{},"ISSN":["0025-6196"],"issn-type":[{"value":"0025-6196","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}