{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T21:01:09Z","timestamp":1778878869353,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mayo Clinic Proceedings"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.4065\/80.4.541","type":"journal-article","created":{"date-parts":[[2009,1,24]],"date-time":"2009-01-24T01:26:10Z","timestamp":1232760370000},"page":"541-545","source":"Crossref","is-referenced-by-count":72,"title":["Ischemic Stroke Associated With Use of an Ephedra-Free Dietary Supplement Containing Synephrine"],"prefix":"10.4065","volume":"80","author":[{"given":"Nicole C.","family":"Bouchard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Ann","family":"Howland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard A.","family":"Greller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis S.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.4065\/80.4.541_bib1","author":"Beales"},{"key":"10.4065\/80.4.541_bib2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4065\/77.1.12","article-title":"Adverse cardiovascular events temporally associated with ma huang, an herbal source of ephedrine","volume":"77","author":"Samenuk","year":"2002","journal-title":"Mayo Clinic Proc"},{"key":"10.4065\/80.4.541_bib3","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1056\/NEJM200012213432502","article-title":"Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids","volume":"343","author":"Haller","year":"2000","journal-title":"N Engl J Med"},{"key":"10.4065\/80.4.541_bib4","author":"Food and Drug Administration"},{"key":"10.4065\/80.4.541_bib5","author":"Food and Drug Administration"},{"key":"10.4065\/80.4.541_bib6","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1126\/science.301.5640.1669c","article-title":"Ephedra-free is not danger-free [letter]","volume":"301","author":"Marcus","year":"2003","journal-title":"Science"},{"key":"10.4065\/80.4.541_bib7","series-title":"Martindale: The Complete Drug Reference","year":"2005"},{"key":"10.4065\/80.4.541_bib8","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/S0731-7085(02)00153-X","article-title":"Determination of adrenergic agonists from extracts and herbal products of Citrus aurantium, L. var. amara by LC","volume":"29","author":"Pellati","year":"2002","journal-title":"J Pharm Biomed Anal"},{"key":"10.4065\/80.4.541_bib9","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/pca.771","article-title":"High-performance liquid chromatography methods for the analysis of adrenergic amines and flavanones in Citrus aurantium L. var. amara","volume":"15","author":"Pellati","year":"2004","journal-title":"Phytochem Anal"},{"key":"10.4065\/80.4.541_bib10","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1345\/aph.1D473","article-title":"Possible association of acute lateral-wall myocardial infarction and bitter orange supplement","volume":"38","author":"Nykamp","year":"2004","journal-title":"Ann Pharmacother"},{"key":"10.4065\/80.4.541_bib11","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.4065\/79.8.1059","article-title":"Exercise-induced syncope associated with QT prolongation and ephedra-free Xenadrine","volume":"79","author":"Nasir","year":"2004","journal-title":"Mayo Clin Proc"},{"key":"10.4065\/80.4.541_bib12","author":"Food and Drug Administration"},{"key":"10.4065\/80.4.541_bib14","unstructured":"Xenadrine ephedra free [Bodybuildingforyou.com Web site]. Available at: www.bodybuildingforyou.com\/xenadrine\/xenadrine-ephedrine-free.htm. Accessibility verified February 1, 2005."},{"key":"10.4065\/80.4.541_bib15","author":"Aceto"},{"key":"10.4065\/80.4.541_bib16","first-page":"247","article-title":"Citrus aurantium as a thermogenic, weight-reduction replacement for ephedra: an overview","volume":"33","author":"Preuss","year":"2002","journal-title":"J Med"},{"key":"10.4065\/80.4.541_bib17","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1016\/0024-3205(95)02195-O","article-title":"Fructus aurantii reduced portal pressure in portal hypertensive rats","volume":"57","author":"Huang","year":"1995","journal-title":"Life Sci"},{"key":"10.4065\/80.4.541_bib18","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1254\/jjp.85.183","article-title":"Hemodynamic effects of synephrine treatment in portal hypertensive rats","volume":"85","author":"Huang","year":"2001","journal-title":"Jpn J Pharmacol"},{"key":"10.4065\/80.4.541_bib19","first-page":"353","article-title":"Effect of Citrus aurantium extract on L-type calcium currents in ventricular myocytes of single guinea pigs [in Chinese]","volume":"28","author":"Fang","year":"2003","journal-title":"Hunan Yi Ke Da Xue Xue Bao"},{"key":"10.4065\/80.4.541_bib20","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1177\/153537020422900802","article-title":"Citrus aurantium, an ingredient of dietary supplements marketed for weight loss: current status of clinical and basic research","volume":"229","author":"Fugh-Berman","year":"2004","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.4065\/80.4.541_bib21","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.amjcard.2004.07.137","article-title":"Safety and efficacy of Citrus aurantium for weight loss","volume":"94","author":"Bent","year":"2004","journal-title":"Am J Cardiol"},{"key":"10.4065\/80.4.541_bib22","series-title":"Textbook of Organic, Medicinal, and Pharmaceutical Chemistry","first-page":"478","year":"1971"},{"key":"10.4065\/80.4.541_bib23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1146\/annurev.me.41.020190.001425","article-title":"Clinical pharmacology of caffeine","volume":"41","author":"Benowitz","year":"1990","journal-title":"Annu Rev Med"},{"key":"10.4065\/80.4.541_bib24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1056\/NEJM197801262980403","article-title":"Effects of caffeine on plasma renin activity, catecholamines and blood pressure","volume":"298","author":"Robertson","year":"1978","journal-title":"N Engl J Med"},{"key":"10.4065\/80.4.541_bib25","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/clpt.1991.152","article-title":"A pharmacodynamic interaction between caffeine and phenylpropanolamine","volume":"50","author":"Brown","year":"1991","journal-title":"Clin Pharmacol Ther"},{"key":"10.4065\/80.4.541_bib26","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","article-title":"A method for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo","year":"1981","journal-title":"Clin Pharmacol Ther"},{"issue":"5, pt 1","key":"10.4065\/80.4.541_bib27","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/cpt1979255part1493","article-title":"Judgments of trained observers on adverse drug reactions","volume":"25","author":"Blanc","year":"1979","journal-title":"Clin Pharmacol Ther"}],"container-title":["Mayo Clinic Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619611632072?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619611632072?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T14:03:44Z","timestamp":1558101824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025619611632072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S0025619611632072"],"URL":"https:\/\/doi.org\/10.4065\/80.4.541","relation":{},"ISSN":["0025-6196"],"issn-type":[{"value":"0025-6196","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}