{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:35:30Z","timestamp":1788914130485,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mayo Clinic Proceedings"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.4065\/81.1.17","type":"journal-article","created":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T20:27:47Z","timestamp":1232742467000},"page":"17-27","source":"Crossref","is-referenced-by-count":122,"title":["Ropinirole in the Treatment of Patients With Restless Legs Syndrome: A US-Based Randomized, Double-Blind, Placebo-Controlled Clinical Trial"],"prefix":"10.4065","volume":"81","author":[{"given":"Richard K.","family":"Bogan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June M.","family":"Fry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus H.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley W.","family":"Carson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally Y.","family":"Ritchie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.4065\/81.1.17_bib1","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1001\/archinte.160.14.2137","article-title":"Epidemiology of restless legs symptoms in adults","volume":"160","author":"Phillips","year":"2000","journal-title":"Arch Intern Med"},{"key":"10.4065\/81.1.17_bib2","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1002\/mds.1209","article-title":"Prevalence of restless legs syndrome among men aged 18 to 64 years: an association with somatic disease and neuropsychiatric symptoms","volume":"16","author":"Ulfberg","year":"2001","journal-title":"Mov Disord"},{"key":"10.4065\/81.1.17_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000050750","article-title":"Restless legs syndrome among working-aged women","volume":"46","author":"Ulfberg","year":"2001","journal-title":"Eur Neurol"},{"key":"10.4065\/81.1.17_bib4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/00000441-200006000-00010","article-title":"Restless legs syndrome: clinical features and treatment","volume":"319","author":"Tan","year":"2000","journal-title":"Am J Med Sci"},{"key":"10.4065\/81.1.17_bib5","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/mds.870100517","article-title":"Toward a better definition of the restless legs syndrome","volume":"10","author":"Walters","year":"1995","journal-title":"Mov Disord"},{"key":"10.4065\/81.1.17_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1389-9457(03)00010-8","article-title":"Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology: a report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health","volume":"4","author":"Allen","year":"2003","journal-title":"Sleep Med"},{"key":"10.4065\/81.1.17_bib7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/mds.870120111","article-title":"Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: a study of 133 patients diagnosed with new standard criteria","volume":"12","author":"Montplaisir","year":"1997","journal-title":"Mov Disord"},{"key":"10.4065\/81.1.17_bib8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.sleep.2004.03.006","article-title":"Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS Epidemiology, Symptoms, and Treatment) primary care study","volume":"5","author":"Hening","year":"2004","journal-title":"Sleep Med"},{"issue":"suppl","key":"10.4065\/81.1.17_bib9","first-page":"A331","article-title":"Sleep and cognitive functioning in people with restless legs syndrome (RLS): comparisons with a normative population [abstract]","volume":"26","author":"Washburn","year":"2003","journal-title":"Sleep"},{"key":"10.4065\/81.1.17_bib10","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0149-2918(04)90136-1","article-title":"Evaluating the quality of life of patients with restless legs syndrome","volume":"26","author":"Abetz","year":"2004","journal-title":"Clin Ther"},{"key":"10.4065\/81.1.17_bib11","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1212\/WNL.52.5.932","article-title":"Striatal dopaminergic function in restless legs syndrome: 18F-dopa and 11C-raclopride PET studies","volume":"52","author":"Turjanski","year":"1999","journal-title":"Neurology"},{"key":"10.4065\/81.1.17_bib12","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1212\/WNL.54.2.502","article-title":"An FDOPA PET study in patients with periodic limb movement disorder and restless legs syndrome","volume":"54","author":"Ruottinen","year":"2000","journal-title":"Neurology"},{"key":"10.4065\/81.1.17_bib13","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1212\/01.WNL.0000078887.16593.12","article-title":"Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome","volume":"61","author":"Connor","year":"2003","journal-title":"Neurology"},{"key":"10.4065\/81.1.17_bib14","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1212\/01.WNL.0000123251.60485.AC","article-title":"Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome","volume":"62","author":"Connor","year":"2004","journal-title":"Neurology"},{"key":"10.4065\/81.1.17_bib15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1389-9457(00)00025-3","article-title":"Opioid and dopamine antagonist drug challenges in untreated restless legs syndrome patients","volume":"2","author":"Winkelmann","year":"2001","journal-title":"Sleep Med"},{"key":"10.4065\/81.1.17_bib16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1055\/s-2002-31514","article-title":"Restless legs syndrome probably induced by risperidone treatment","volume":"35","author":"Wetter","year":"2002","journal-title":"Pharmacopsychiatry"},{"key":"10.4065\/81.1.17_bib17","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1212\/WNL.38.12.1845","article-title":"Treatment of restless legs syndrome and periodic movements during sleep with L-dopa: a double-blind, controlled study","volume":"38","author":"Brodeur","year":"1988","journal-title":"Neurology"},{"key":"10.4065\/81.1.17_bib18","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/sleep\/16.8.717","article-title":"A double-blind, placebo-controlled study of the treatment of periodic limb movements in sleep using carbidopa\/levodopa and propoxyphene","volume":"16","author":"Kaplan","year":"1993","journal-title":"Sleep"},{"key":"10.4065\/81.1.17_bib19","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/sleep\/18.8.681","article-title":"L-dopa therapy of uremic and idiopathic restless legs syndrome: a double-blind, crossover trial","volume":"18","author":"Trenkwalder","year":"1995","journal-title":"Sleep"},{"key":"10.4065\/81.1.17_bib20","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/sleep\/22.8.1073","article-title":"Rapid onset of action of levodopa in restless legs syndrome: a double-blind, randomized, multicenter, crossover trial","volume":"22","author":"Benes","year":"1999","journal-title":"Sleep"},{"key":"10.4065\/81.1.17_bib21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1212\/WNL.52.2.285","article-title":"A controlled study of additional sr-L-dopa in L-dopa-responsive restless legs syndrome with late-night symptoms","volume":"52","author":"Collado-Seidel","year":"1999","journal-title":"Neurology"},{"key":"10.4065\/81.1.17_bib22","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00702-003-0814-z","article-title":"Acute double-blind, placebo-controlled sleep laboratory and clinical follow-up studies with a combination treatment of rr-L-dopa and sr-L-dopa in restless legs syndrome","volume":"110","author":"Saletu","year":"2003","journal-title":"J Neural Transm"},{"key":"10.4065\/81.1.17_bib23","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/mds.10503","article-title":"One-year treatment with standard and sustained-release levodopa: appropriate long-term treatment of restless legs syndrome?","volume":"18","author":"Trenkwalder","year":"2003","journal-title":"Mov Disord"},{"key":"10.4065\/81.1.17_bib24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/sleep\/19.3.205","article-title":"Augmentation of the restless legs syndrome with carbidopa\/levodopa","volume":"19","author":"Allen","year":"1996","journal-title":"Sleep"},{"key":"10.4065\/81.1.17_bib25","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/sleep\/27.3.557","article-title":"Practice parameters for the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder","volume":"27","author":"Littner","year":"2004","journal-title":"Sleep"},{"key":"10.4065\/81.1.17_bib26","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/sleep\/27.3.560","article-title":"An update on the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder","volume":"27","author":"Hening","year":"2004","journal-title":"Sleep"},{"key":"10.4065\/81.1.17_bib27","doi-asserted-by":"crossref","first-page":"916","DOI":"10.4065\/79.7.916","article-title":"An algorithm for the management of restless legs syndrome","volume":"79","author":"Silber","year":"2004","journal-title":"Mayo Clin Proc"},{"key":"10.4065\/81.1.17_bib28","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1093\/sleep\/27.5.907","article-title":"Ropinirole decreases periodic leg movements and improves sleep parameters in patients with restless legs syndrome","volume":"27","author":"Allen","year":"2004","journal-title":"Sleep"},{"key":"10.4065\/81.1.17_bib29","first-page":"92","article-title":"Ropinirole in the treatment of restless legs syndrome: results from the TREAT RLS 1 study, a 12 week, randomised, placebo controlled study in 10 European countries","volume":"75","author":"Trenkwalder","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.4065\/81.1.17_bib30","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1002\/mds.20257","article-title":"Ropinirole is effective in the treatment of restless legs syndrome: TREAT RLS 2: a 12-week, double-blind, randomized, parallel-group, placebo-controlled study","volume":"19","author":"Walters","year":"2004","journal-title":"Mov Disord"},{"issue":"suppl","key":"10.4065\/81.1.17_bib31","first-page":"A294","article-title":"Maintained efficacy with ropinirole: results of a multinational 36-week study of patients with RLS [abstract]","volume":"27","author":"Karrasch","year":"2004","journal-title":"Sleep"},{"issue":"suppl 1","key":"10.4065\/81.1.17_bib32","first-page":"A42","article-title":"Ropinirole is well tolerated and effective for the long-term treatment of RLS [abstract]","volume":"64","author":"Garcia-Borreguero","year":"2005","journal-title":"Neurology"},{"key":"10.4065\/81.1.17_bib33","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1389-9457(02)00258-7","article-title":"Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome","volume":"4","author":"Walters","year":"2003","journal-title":"Sleep Med"},{"key":"10.4065\/81.1.17_bib34","series-title":"ECDEU Assessment Manual for Psychopharmacology","first-page":"217","year":"1976"},{"key":"10.4065\/81.1.17_bib35","series-title":"Measuring Functioning and Well-being: The Medical Outcomes Study Approach","first-page":"235","article-title":"Sleep measures","author":"Hays","year":"1992"},{"key":"10.4065\/81.1.17_bib36","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"key":"10.4065\/81.1.17_bib37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.sleep.2004.07.006","article-title":"Psychometric properties of the Medical Outcomes Study Sleep measure","volume":"6","author":"Hays","year":"2005","journal-title":"Sleep Med"},{"key":"10.4065\/81.1.17_bib38","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/(SICI)1097-4679(199901)55:1<79::AID-JCLP8>3.0.CO;2-7","article-title":"Adult and geriatric normative data and validation of the profile of mood states","volume":"55","author":"Nyenhuis","year":"1999","journal-title":"J Clin Psychol"},{"key":"10.4065\/81.1.17_bib39","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1001\/archinte.165.11.1286","article-title":"Restless legs syndrome prevalence and impact: REST general population study","volume":"165","author":"Allen","year":"2005","journal-title":"Arch Intern Med"}],"container-title":["Mayo Clinic Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619611616315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619611616315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,22]],"date-time":"2018-12-22T02:56:50Z","timestamp":1545447410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025619611616315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0025619611616315"],"URL":"https:\/\/doi.org\/10.4065\/81.1.17","relation":{},"ISSN":["0025-6196"],"issn-type":[{"value":"0025-6196","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}