{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:48:32Z","timestamp":1791791312905,"version":"4.3.4"},"reference-count":32,"publisher":"Korean College of Rheumatology","issue":"4","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"KAN Research Institute, Inc.","id":[{"id":"https:\/\/ror.org\/02b3jn477","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Eisai","id":[{"id":"https:\/\/ror.org\/04vvh7p27","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.jrd.or.kr"],"crossmark-restriction":true},"short-container-title":["J Rheum Dis"],"published-print":{"date-parts":[[2026,10,1]]},"DOI":"10.4078\/jrd.2025.0182","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:25:47Z","timestamp":1784593547000},"page":"279-294","update-policy":"https:\/\/doi.org\/10.4078\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploratory analysis of early changes in peripheral immune cell proportions and clinical response following methotrexate and biologic treatment in rheumatoid arthritis"],"prefix":"10.4078","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9853-8057","authenticated-orcid":false,"given":"Sei","family":"Muraoka","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"corresponding-author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0202-6031","authenticated-orcid":false,"given":"Tomohiro","family":"Yamada","sequence":"additional","affiliation":[{"name":"KAN Research Institute, Inc., Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"corresponding-author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0117-0784","authenticated-orcid":false,"given":"Nobuyuki","family":"Yasuda","sequence":"additional","affiliation":[{"name":"KAN Research Institute, Inc., Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5300-9622","authenticated-orcid":false,"given":"Jungo","family":"Kakuta","sequence":"additional","affiliation":[{"name":"KAN Research Institute, Inc., Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9987-9267","authenticated-orcid":false,"given":"Hiroshi","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4321-5357","authenticated-orcid":false,"given":"Satoshi","family":"Mizutani","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6871-5593","authenticated-orcid":false,"given":"Makoto","family":"Kaburaki","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4022-1962","authenticated-orcid":false,"given":"Toshio","family":"Imai","sequence":"additional","affiliation":[{"name":"KAN Research Institute, Inc., Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3482-074X","authenticated-orcid":false,"given":"Toshihiro","family":"Nanki","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2544","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/cells7100161"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-36999-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex012"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1244-x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028918"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6894374"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/cells8080871"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01913"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/mr\/roaf006"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/nri3158"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/srep20686"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215192"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203566"},{"key":"ref15","unstructured":"Fukuyo S, Nakayamada S, Iwata S, Kubo S, Saito K, Tanaka Y. Abatacept therapy reduces CD28+CXCR5+ follicular helper-like T cells in patients with rheumatoid arthritis. Clin Exp Rheumatol 2017;35:562-70."},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/cells12242808"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-023-03236-y"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110386"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1213344"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/ar2718"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/art.39489"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032534"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.085787"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/art.23473"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/art.30599"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00887"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00353"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/698192"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-005-0106-0"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120257"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1002\/art.41555"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2020.1868675"}],"container-title":["Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pdf.medrang.co.kr\/JRD\/2026\/033\/JRD033-04-279.pdf","content-type":"unspecified","content-version":"tdm","intended-application":"text-mining"},{"URL":"https:\/\/pdf.medrang.co.kr\/JRD\/2026\/033\/JRD033-04-279.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:22:50Z","timestamp":1791789770000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrd.or.kr\/journal\/view.html?doi=10.4078\/jrd.2025.0182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10,1]]}},"alternative-id":["10.4078\/jrd.2025.0182"],"URL":"https:\/\/doi.org\/10.4078\/jrd.2025.0182","relation":{},"ISSN":["2093-940X","2233-4718"],"issn-type":[{"value":"2093-940X","type":"print"},{"value":"2233-4718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]},"assertion":[{"value":"http:\/\/www.jrd.or.kr\/journal\/view.html?doi=10.4078\/jrd.2025.0182","URL":"http:\/\/www.jrd.or.kr\/journal\/view.html?doi=10.4078\/jrd.2025.0182","name":"the_journal","label":"J Rheum Dis","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2025-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":3,"name":"published","label":"Online First","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-01","order":4,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2026 The Korean College of Rheumatology","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}