{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:18:35Z","timestamp":1770484715404,"version":"3.49.0"},"reference-count":0,"publisher":"PAGEPress Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>Objectives: To evaluate the effects of upregulators of nitric oxide in one patient with Peyronie&amp;rsquo;s disease, after non significant improvement following intracavernosal verapamil. Methods: A 20-years-old Caucasian male presented with penile induration in flaccid state, persistent during erection and associated with mild pain at third middle of penis. After treatment with intracavernosal verapamil for 4 months with relief of penile discomfort, followed by counseling on the use of penile extender for at least 6 hours per day, he was prescribed pentoxifylline associated with tadalafil plus levo-arginine, propionil-carnitine and Vitamin B3. Results: After almost 2 years, the septal thickness was reduced at ultrasound evaluation after this &amp;ldquo;triple oxygenant therapy&amp;rdquo;. Conclusion: NO-iNOS biology in Peyronie patients is the very protagonist in modulating penile fibrosis through up-regulation of NO-cGMP pathway that influences penile health by preventing and reversing fibrosis in the tunical albuginea.<\/jats:p>","DOI":"10.4081\/aiua.2013.1.36","type":"journal-article","created":{"date-parts":[[2013,4,19]],"date-time":"2013-04-19T07:32:43Z","timestamp":1366356763000},"page":"36","source":"Crossref","is-referenced-by-count":11,"title":["Peyronie\u2019s disease: A \u201ctriple oxygenant therapy\u201d"],"prefix":"10.4081","volume":"85","author":[{"given":"Francesco","family":"Ciociola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Maria","family":"Colpi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2013,4,19]]},"container-title":["Archivio Italiano di Urologia e Andrologia"],"original-title":[],"link":[{"URL":"http:\/\/www.pagepressjournals.org\/index.php\/aiua\/article\/viewFile\/1590\/1190","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T08:36:04Z","timestamp":1463042164000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.pagepressjournals.org\/index.php\/aiua\/article\/view\/aiua.2013.1.36"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,19]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,4,19]]}},"URL":"https:\/\/doi.org\/10.4081\/aiua.2013.1.36","relation":{},"ISSN":["2282-4197","1124-3562"],"issn-type":[{"value":"2282-4197","type":"electronic"},{"value":"1124-3562","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4,19]]}}}