{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:37:16Z","timestamp":1762659436571},"reference-count":0,"publisher":"PAGEPress Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>Objectives: To evaluate the impact of the prostatic-urethral angulation (PUA) on the treatment efficacy of selective alpha-1A receptor blocker in male patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia (LUTS\/BPH). Materials and methods: A total of 80 patients with LUTS\/BPH and with mean age 53.3 \u00b1 6.3 (range 47-70) were included in our prospective comparative study. The patients were classified into 2 groups as a consecutive cases 40 in each one depending on the PUA either \u2264 35\u00b0 (group A) or &amp;gt; 35\u00b0 (group B). PUA and different prostatic parameters were measured using transrectal ultrasound. Prostate-specific antigen (PSA), the International Prostate Symptom Score and quality of life score (IPSS\/QoL score), maximum flow rate (Q&lt;sub&gt;max&lt;\/sub&gt;), and postvoid residual (PVR) volume were compared between the groups. The clinical significance of PUA was evaluated after 8 weeks of medical treatment with tamsulosin hydrochloride 0.4 mg daily. Results: Baseline evaluation (pre-treatment) for both groups were comparable to each other with no clinically significant difference regarding age, PSA, IPSS\/QoL score, Qmax and PVR volume (P-value &amp;gt; 0.05). Comparison of parameters after 8 weeks showed that tamsulosin hydrochloride improved the total IPSS and all subscores (P &amp;lt; 0.001), QoL (P = 0.001), Q&lt;sub&gt;max&lt;\/sub&gt; (P = 0.002), and PVR (P = 0.04) in group A (Table 1). Conclusion: Tamsulosin hydrochloride appears to be less effective in improving IPSS\/Qol score, Qmax and PVR in patients with lager PUA. The PUA might be a predictor for the treatment efficacy of \u03b1-blockers and more studies are warranted in the future before the final conclusion.<\/jats:p>","DOI":"10.4081\/aiua.2015.3.238","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T03:15:25Z","timestamp":1444360525000},"page":"238","source":"Crossref","is-referenced-by-count":1,"title":["Clinical significance of prostatic-urethral angulation on the treatment outcome of patients with symptomatic benign prostatic hyperplasia treated with tamsulosin hydrochloride"],"prefix":"10.4081","volume":"87","author":[{"given":"Hassan","family":"El-Tatawy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek","family":"Gameel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Abo","family":"El-enen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman","family":"Hagras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman","family":"Mousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdel Hamid","family":"El-Bahnasy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Abdel","family":"Raheem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Abu-dewan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2015,9,30]]},"container-title":["Archivio Italiano di Urologia e Andrologia"],"original-title":[],"link":[{"URL":"http:\/\/www.pagepressjournals.org\/index.php\/aiua\/article\/viewFile\/5550\/4848","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T08:41:57Z","timestamp":1463042517000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.pagepressjournals.org\/index.php\/aiua\/article\/view\/aiua.2015.3.238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,30]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,9,30]]}},"URL":"https:\/\/doi.org\/10.4081\/aiua.2015.3.238","relation":{},"ISSN":["2282-4197","1124-3562"],"issn-type":[{"value":"2282-4197","type":"electronic"},{"value":"1124-3562","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9,30]]}}}