{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:44:18Z","timestamp":1785516258989,"version":"3.56.0"},"reference-count":29,"publisher":"PAGEPress Publications","issue":"4","license":[{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>Objectives: Renal ischemia\/reperfusion (I\/R) injury is a common cause of acute kidney injury. The aim of this study was to investigate the effect of butein on renal I\/R injury. Materials and methods: Twenty-seven rats were randomly allocated to three groups (n = 9): a sham group, a renal I\/Runtreated (control) group, and a renal I\/R-butein group. The sham group underwent only opening and closing of the peritoneum. In the control group, an experimental I\/R model was created and 1 cc isotonic saline was applied to the peritoneum. In the butein group, the experimental I\/R model was created and 1 mg\/kg butein was administered intraperitoneally 15 minutes before the beginning of ischemia. The left kidneys of the rats were histopathologically examined for tissue damage caused by I\/R. Results: Histopathological examination of the tissue damage revealed that all kidneys in the sham group were normal. By contrast, 2 in the control group (22.2%) had small focal damaged areas, 1 (11.1%) had &lt; 10% cortical damage, 5 (55.6%) had 10-25% cortical damage, and 1 (11.1%) had 25-75% cortical damage. The butein group had 1 (11.1%) normal kidney, 2 (22.2%) with small focal damaged areas, 4 (44.4%) with &lt; 10% cortical damage, and 2 (22.2%) with 10-25% cortical damage. Tissue damage was significantly lower in the sham group than in the control and butein groups (p &lt; 0.01). No statistically significant differences were observed in the histopathology of the control and butein groups (p &gt; 0.05). Conclusions: Intraperitoneal administration of butein had no significant effect on renal tissue injury.<\/jats:p>","DOI":"10.4081\/aiua.2020.4.335","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T16:41:42Z","timestamp":1608309702000},"source":"Crossref","is-referenced-by-count":1,"title":["Effects of butein on renal ischemia\/reperfusion injury: An experimental study"],"prefix":"10.4081","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7637-133X","authenticated-orcid":false,"given":"Mehmet Akif","family":"Ramazanoglu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1348-5273","authenticated-orcid":false,"given":"Tuncay","family":"Toprak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Remzi","family":"Erdem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulistan","family":"Gumrukcu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice","family":"Kucuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feridun","family":"Sengor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"key":"27948","doi-asserted-by":"crossref","unstructured":"Sagiroglu T, Torun N, Yagci M, Yalta T, Sagiroglu G, Oguz S. Effects of apelin and leptin on renal functions following renal ischemia\/reperfusion: An experimental study. Experimental and therapeutic medicine 2012;3:908-14.","DOI":"10.3892\/etm.2012.499"},{"key":"27949","doi-asserted-by":"crossref","unstructured":"Snoeijs MG, Vink H, Voesten N, et al. Acute ischemic injury to the renal microvasculature in human kidney transplantation. American Journal of Physiology-Renal Physiology 2010;299:F1134-F40.","DOI":"10.1152\/ajprenal.00158.2010"},{"key":"27950","doi-asserted-by":"crossref","unstructured":"Zhang J, Zou Yr, Zhong X, et al. Erythropoietin pretreatment ameliorates renal ischaemia\u2010reperfusion injury by activating PI3K\/Akt signalling. Nephrology 2015;20:266-72.","DOI":"10.1111\/nep.12384"},{"key":"27951","doi-asserted-by":"crossref","unstructured":"Wang L, Liu X, Chen H, et al. Effect of picroside II on apoptosis induced by renal ischemia\/reperfusion injury in rats. Experimental and therapeutic medicine 2015;9:817-22.","DOI":"10.3892\/etm.2015.2192"},{"key":"27952","doi-asserted-by":"crossref","unstructured":"Barinaga M. Forging a path to cell death. Science 1996;273:735-7.","DOI":"10.1126\/science.273.5276.735"},{"key":"27953","doi-asserted-by":"crossref","unstructured":"Eltzschig HK, Eckle T. Ischemia and reperfusion\u2014from mechanism to translation. Nature medicine 2011;17:1391.","DOI":"10.1038\/nm.2507"},{"key":"27954","doi-asserted-by":"crossref","unstructured":"Ljungberg B, Bensalah K, Canfield S, et al. EAU guidelines on renal cell carcinoma: 2014 update. European urology 2015;67:913-24.","DOI":"10.1016\/j.eururo.2015.01.005"},{"key":"27955","doi-asserted-by":"crossref","unstructured":"Conesa EL, Valero F, Nadal JC, et al. N-acetyl-L-cysteine improves renal medullary hypoperfusion in acute renal failure. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2001;281:R730-R7.","DOI":"10.1152\/ajpregu.2001.281.3.R730"},{"key":"27956","doi-asserted-by":"crossref","unstructured":"Rhoden E, Tel\u00f6ken C, Lucas M, et al. Protective effect of allopurinol in the renal ischemia\u2013reperfusion in uninephrectomized rats. General Pharmacology: The Vascular System 2000;35:189-93.","DOI":"10.1016\/S0306-3623(01)00105-7"},{"key":"27957","doi-asserted-by":"crossref","unstructured":"Feitoza CQ, C\u00e2mara NO, Pinheiro HS, et al. Cyclooxygenase 1 and\/or 2 blockade ameliorates the renal tissue damage triggered by ischemia and reperfusion injury. International immunopharmacology 2005;5:79-84.","DOI":"10.1016\/j.intimp.2004.09.024"},{"key":"27958","doi-asserted-by":"crossref","unstructured":"Cheng Z-J, Kuo S-C, Chan S-C, Ko F-N, Teng C-M. Antioxidant properties of butein isolated from Dalbergia odorifera. Biochimica et Biophysica Acta (BBA)-Lipids and Lipid Metabolism 1998;1392:291-9.","DOI":"10.1016\/S0005-2760(98)00043-5"},{"key":"27959","doi-asserted-by":"crossref","unstructured":"Lee SH, Nan J-X, Zhao YZ, et al. The chalcone butein from Rhus verniciflua shows antifibrogenic activity. Planta medica 2003;69:990-4.","DOI":"10.1055\/s-2003-45143"},{"key":"27960","doi-asserted-by":"crossref","unstructured":"Lu M, Wang S, Han X, Lv D. Butein inhibits NF-\u03baB activation and reduces infiltration of inflammatory cells and apoptosis after spinal cord injury in rats. Neuroscience letters 2013;542:87-91.","DOI":"10.1016\/j.neulet.2013.03.004"},{"key":"27961","unstructured":"Council NR. Guide for the care and use of laboratory animals: National Academies Press; 2010."},{"key":"27962","doi-asserted-by":"crossref","unstructured":"Altintas R, Polat A, Vardi N, et al. The protective effects of apocynin on kidney damage caused by renal ischemia\/reperfusion. Journal of endourology 2013;27:617-24.","DOI":"10.1089\/end.2012.0556"},{"key":"27963","doi-asserted-by":"crossref","unstructured":"Basile DP, Friedrich JL, Spahic J, et al. Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury. American Journal of Physiology-Renal Physiology 2011;300:F721-F33.","DOI":"10.1152\/ajprenal.00546.2010"},{"key":"27964","doi-asserted-by":"crossref","unstructured":"Huber TB, Edelstein CL, Hartleben B, et al. Emerging role of autophagy in kidney function, diseases and aging. Autophagy 2012;8:1009-31.","DOI":"10.4161\/auto.19821"},{"key":"27965","doi-asserted-by":"crossref","unstructured":"Land WG. The role of postischemic reperfusion injury and other nonantigen-dependent inflammatory pathways in transplantation. 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Phenolic-rich fraction from Rhus verniciflua Stokes (RVS) suppress inflammatory response via NF-\u03baB and JNK pathway in lipopolysaccharide-induced RAW 264.7 macrophages. Journal of ethnopharmacology 2007;110:490-7.","DOI":"10.1016\/j.jep.2006.10.013"},{"key":"27973","doi-asserted-by":"crossref","unstructured":"Lee SH, Seo GS, Jin XY, Ko G, Sohn DH. Butein blocks tumor necrosis factor \u03b1-induced interleukin 8 and matrix metalloproteinase 7 production by inhibiting p38 kinase and osteopontin mediated signaling events in HT-29 cells. Life sciences 2007;81:1535-43.","DOI":"10.1016\/j.lfs.2007.09.024"},{"key":"27974","doi-asserted-by":"crossref","unstructured":"Takano\u2010Ishikawa Y, Goto M, Yamaki K. Inhibitory effects of several flavonoids on E\u2010selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor\u2010\u03b1. 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