{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:10:48Z","timestamp":1768317048052,"version":"3.49.0"},"reference-count":15,"publisher":"PAGEPress Publications","issue":"1","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>Introduction: Testicular cancers represent about 5% of all urological malignancies and 1-1.5% of all male neoplasms. Most of the testicular cancers are localized (68%) at diagnosis. Bulky masses in the scrotum are rare. We present a rare case of bulky testicular cancer with retroperitoneal spread through the inguinal canal. Case report: A 44-year-old man came to the emergency department referring weakness and the presence of a scrotal mass. At physical examination, a voluminous mass was found, with necrotic phenomena within the scrotum. Abdomen was tense and sore. Abdominal CT scan revealed a bulky testicular mass spreading to the retroperitoneal space through the inguinal canal with node enlargement. Patient underwent orchiectomy with excision of infiltrated scrotum skin. Histologic diagnosis confirmed a typical form seminoma. The patient was then treated with a cisplatin-based chemotherapy, with a partial response. The patient recently relapsed and he is being treated with a new line of chemotherapy and subsequent surgery with or without radiotherapy. Conclusions: We described a rare presentation of testicular cancer. This case highlights the importance of a multidisciplinary approach to rare testis tumour presentation and early diagnosis for testicular cancers.<\/jats:p>","DOI":"10.4081\/aiua.2021.1.64","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T13:23:35Z","timestamp":1616419415000},"page":"64-67","source":"Crossref","is-referenced-by-count":3,"title":["Retroperitoneal extension of massive ulcerated testicular seminoma through the inguinal canal: A case report"],"prefix":"10.4081","volume":"93","author":[{"given":"Alessio","family":"Antonaci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Fasanella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikiela","family":"Galica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Tinari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamara","family":"Giampietro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Di Marino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Delli Pizzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Basilico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Schips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Marchioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"36190","doi-asserted-by":"crossref","unstructured":"Chia VM, Quraishi SM, Devesa SS, et al. International trends in the incidence of testicular cancer, 1973-2002. Cancer Epidemiol Biomark Prev. 2010; 19:1151-9.","DOI":"10.1158\/1055-9965.EPI-10-0031"},{"key":"36191","doi-asserted-by":"crossref","unstructured":"Huyghe E, Matsuda T, Thonneau P. Increasing incidence of testicular cancer worldwide: a review. J Urol. 2003; 170:5-11.","DOI":"10.1097\/01.ju.0000053866.68623.da"},{"key":"36192","unstructured":"Shanmugalingam T, Soultati A, Chowdhury S, et al. Global incidence and outcome of testicular cancer. Clin Epidemiol. 2013;5:417-27."},{"key":"36193","doi-asserted-by":"crossref","unstructured":"Moch H, Cubilla AL, Humphrey PA, et al. The 2016 WHO classification of tumours of the urinary system and male genital organs-Part A: Renal, penile, and testicular tumours. Eur Urol. 2016; 70:93-105.","DOI":"10.1016\/j.eururo.2016.02.029"},{"key":"36194","doi-asserted-by":"crossref","unstructured":"Palumbo C, Mistretta FA, Mazzone E, et al. Contemporary incidence and mortality rates in patients with testicular germ cell tumors. Clin Genitourin Cancer. 2019; 17:e1026-35.","DOI":"10.1016\/j.clgc.2019.06.003"},{"key":"36195","doi-asserted-by":"crossref","unstructured":"Saxman SB, Finch D, Gonin R, Einhorn LH. Long-term follow-up of a phase III study of three versus four cycles of bleomycin, etoposide, and cisplatin in favorable-prognosis germ-cell tumors: the Indian University experience. J Clin Oncol. 1998; 16:702-6.","DOI":"10.1200\/JCO.1998.16.2.702"},{"key":"36196","unstructured":"Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 1990. 2009; 45:228-47."},{"key":"36197","doi-asserted-by":"crossref","unstructured":"Mihor A, Tomsic S, Zagar T, et al. Socioeconomic Inequalities in Cancer Incidence in Europe: A Comprehensive Review of Populationbased Epidemiological Studies. Radiol Oncol. 2020; 54:1-13.","DOI":"10.2478\/raon-2020-0008"},{"key":"36198","doi-asserted-by":"crossref","unstructured":"Marchioni M, Martel T, Bandini M, et al. Marital status and gender affect stage, tumor grade, treatment type and cancer specific mortality in T1-2 N0 M0 renal cell carcinoma. World J Urol. 2017;35:1899-905.","DOI":"10.1007\/s00345-017-2082-9"},{"key":"36199","doi-asserted-by":"crossref","unstructured":"Macleod LC, Cannon SS, Ko O, Schade GR, et al. Disparities in Access and Regionalization of Care in Testicular Cancer. Clin Genitourin Cancer. 2018; 16:e785-93.","DOI":"10.1016\/j.clgc.2018.02.014"},{"key":"36200","doi-asserted-by":"crossref","unstructured":"Honecker F, Aparicio J, Berney D, et al. ESMO Consensus Conference on testicular germ cell cancer: diagnosis, treatment and follow-up. Ann Oncol. 2018; 29:1658-86.","DOI":"10.1093\/annonc\/mdy217"},{"key":"36201","doi-asserted-by":"crossref","unstructured":"Warde P, Specht L, Horwich A, et al. Prognostic factors for relapse in stage I seminoma managed by surveillance: a pooled analysis. J Clin Oncol 2002;20:4448-52.","DOI":"10.1200\/JCO.2002.01.038"},{"key":"36202","doi-asserted-by":"crossref","unstructured":"Aparicio J, Germ\u00e0 JR, Garc\u00eda del Muro X, et al. Risk-adapted management for patients with clinical stage I seminoma: the Second Spanish Germ Cell Cancer Cooperative Group study. J Clin Oncol. 2005; 23:8717-23.","DOI":"10.1200\/JCO.2005.01.9810"},{"key":"36203","doi-asserted-by":"crossref","unstructured":"Park S, Lee S, Lee J, et al. Salvage chemotherapy with paclitaxel, ifosfamide, and cisplatin (TIP) in relapsed orcisplatin-refractory germ cell tumors. Onkologie. 2011; 34:416-20.","DOI":"10.1159\/000331129"},{"key":"36204","doi-asserted-by":"crossref","unstructured":"Oldenburg J, Foss\u00e5 SD, Nuver J, et al. Testicular seminoma and non-seminoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol Off J Eur Soc Med Oncol. 2013;24 Suppl 6:vi125-132.","DOI":"10.1093\/annonc\/mdt304"}],"container-title":["Archivio Italiano di Urologia e Andrologia"],"original-title":[],"link":[{"URL":"https:\/\/www.pagepressjournals.org\/index.php\/aiua\/article\/download\/aiua.2021.1.64\/9315","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepressjournals.org\/index.php\/aiua\/article\/download\/aiua.2021.1.64\/9315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T13:23:52Z","timestamp":1616419432000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pagepressjournals.org\/index.php\/aiua\/article\/view\/aiua.2021.1.64"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,19]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,3,22]]}},"URL":"https:\/\/doi.org\/10.4081\/aiua.2021.1.64","relation":{},"ISSN":["2282-4197","1124-3562"],"issn-type":[{"value":"2282-4197","type":"electronic"},{"value":"1124-3562","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,19]]}}}