{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T20:44:30Z","timestamp":1775940270235,"version":"3.50.1"},"reference-count":13,"publisher":"PAGEPress Publications","issue":"1","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>Objective: Propionibacterium acnes has been implicated in the pathogenesis of prostate disease as acute and chronic prostatic inflammation, benign prostatic hyperplasia and prostate cancer although it should still be clarified if Propionibacterium acnes (P. acnes) is a commensal or accidental prostate pathogen. Aiming to evaluate the pathogenic potential for genitourinary tract of Propionibacterium acnes, we investigated the frequency of P. acnes genome in urine or semen samples from men with recurrent symptoms of urinary infection and negative testing for the most common urinary tract pathogens and sexually transmitted infections (STI) agents as Chlamydia trachomatis, Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum and Ureaplasma urealyticum. Materials and methods: The DNA extracted from urine and semen samples was analyzed for evaluating the P. acnes genome presence by real-time polymerase chain reaction (PCR). Infections were treated with vancomycin and cephalosporins antibiotics and then the search for the P.acnes genome by realtime PCR was repeated. Results: The P. acnes qualitative real-time PCR revealed the genome in 73 out of 159 samples examined (108 urine and 51 semen). After antibiotic therapy, P. acnes was never detected. Conclusions: These results suggested that P. acnes genome determination should be performed in cases of chronic inflammation in the urinary tract to identify an unknown potential pathogen of genitourinary tract.<\/jats:p>","DOI":"10.4081\/aiua.2022.1.62","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T13:58:27Z","timestamp":1648562307000},"page":"62-64","source":"Crossref","is-referenced-by-count":7,"title":["Propionibacterium acnes in urine and semen samples from men with urinary infection"],"prefix":"10.4081","volume":"94","author":[{"given":"Lucrezia","family":"Manente","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Gargiulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Gargiulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Dovinola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"49477","doi-asserted-by":"crossref","unstructured":"Leheste JR, Ruvolo KE, Chrostowski JE, et al. P. acnes-driven disease pathology: current knowledge and future directions. Front Cell Infect Microbiol. 2017; 7:81.","DOI":"10.3389\/fcimb.2017.00081"},{"key":"49478","doi-asserted-by":"crossref","unstructured":"Kakegawa T, Bae Y, Ito T, et al. Frequency of Propionibacterium acnes infection in prostate glands with negative biopsy results is an independent risk factor for prostate cancer in patients with increased serum PSA titers. PLoS One. 2017; 12:e0169984","DOI":"10.1371\/journal.pone.0169984"},{"key":"49479","doi-asserted-by":"crossref","unstructured":"Shannon BA, Cohen RJ, Garrett KL. The antibody response to Propionibacterium acnes is an independent predictor of serum prostate-specific antigen levels in biopsy-negative men. BJU Int. 2008; 101:429-35.","DOI":"10.1111\/j.1464-410X.2007.07214.x"},{"key":"49480","doi-asserted-by":"crossref","unstructured":"Griebling TL. Urologic Diseases in America project: trends in resource use for urinary tract infections in men. J Urol. 2005;173:1288-94.","DOI":"10.1097\/01.ju.0000155595.98120.8e"},{"key":"49481","doi-asserted-by":"crossref","unstructured":"Marques LP, Flores JT, de Barros O, et al. Epidemiological and clinical aspects of urinary tract infection in community-dwelling elderly women. Braz J Infect Dis. 2012; 16:436-41.","DOI":"10.1016\/j.bjid.2012.06.025"},{"key":"49482","doi-asserted-by":"crossref","unstructured":"Gandaglia G, Zaffuto E, Fossati N, et al. The role of prostatic inflammation in the development and progression of benign and malignant diseases. Curr Opin Urol. 2017; 27:99-106.","DOI":"10.1097\/MOU.0000000000000369"},{"key":"49483","doi-asserted-by":"crossref","unstructured":"De Marzo AM, Platz EA, Sutcliffe S, et al. Inflammation in prostate carcinogenesis. Nat Rev Cancer. 2007; 7:256-269.","DOI":"10.1038\/nrc2090"},{"key":"49484","doi-asserted-by":"crossref","unstructured":"Alexeyev O, Bergh J, Marklund I, et al. Association between the presence of bacterial 16S RNA in prostate specimens taken during transurethral resection of prostate and subsequent risk of prostate cancer (Sweden). Cancer Causes Control. 2006; 17:1127-1133.","DOI":"10.1007\/s10552-006-0054-2"},{"key":"49485","doi-asserted-by":"crossref","unstructured":"Fassi Fehri L, Mak TN, Laube B, et al. Prevalence of Propionibacterium acnes in diseased prostates and its inflammatory and transforming activity on prostate epithelial cells. Int J Med Microbiol. 2011; 301:69-78.","DOI":"10.1016\/j.ijmm.2010.08.014"},{"key":"49486","doi-asserted-by":"crossref","unstructured":"Perry AL, Lambert PA. Propionibacterium acnes. Lett Appl Microbiol. 2006; 42:185-8.","DOI":"10.1111\/j.1472-765X.2006.01866.x"},{"key":"49487","doi-asserted-by":"crossref","unstructured":"Cai T, Pisano F, Nesi G et al. Chlamydia trachomatis versus common uropathogens as a cause of chronic bacterial prostatitis: is there any differences? Results of a prospective parallel-cohort study. Investig Clin Urol. 2017; 58:460-467.","DOI":"10.4111\/icu.2017.58.6.460"},{"key":"49488","doi-asserted-by":"crossref","unstructured":"Horner PJ, Martin DH. Mycoplasma genitalium infection in men. J Infect Dis. 2017; 216:S396-405.","DOI":"10.1093\/infdis\/jix145"},{"key":"49489","doi-asserted-by":"crossref","unstructured":"Davidsson, S, M\u00f6lling P, Rider JR, et al. Frequency and typing of Propionibacterium acnes in prostate tissue obtained from men with and without prostate cancer. Infect. Agent Cancer. 2016; 11:36.","DOI":"10.1186\/s13027-016-0074-9"}],"container-title":["Archivio Italiano di Urologia e Andrologia"],"original-title":[],"link":[{"URL":"https:\/\/www.pagepressjournals.org\/index.php\/aiua\/article\/download\/aiua.2022.1.62\/9970","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepressjournals.org\/index.php\/aiua\/article\/download\/aiua.2022.1.62\/9970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T11:03:51Z","timestamp":1700391831000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pagepressjournals.org\/index.php\/aiua\/article\/view\/aiua.2022.1.62"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,29]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,3,29]]}},"URL":"https:\/\/doi.org\/10.4081\/aiua.2022.1.62","relation":{},"ISSN":["2282-4197","1124-3562"],"issn-type":[{"value":"2282-4197","type":"electronic"},{"value":"1124-3562","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3,29]]}}}