{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:50:03Z","timestamp":1773017403259,"version":"3.50.1"},"reference-count":10,"publisher":"PAGEPress Publications","issue":"1","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>Objectives: La Peyronie's disease tends to be underdiagnosed and undertreated. In Italy it affects about 7% of the population aged between 50 and 70 years old. The aim of this study is to evaluate the quality of life of patients undergoing iontophoretic therapy with verapamil and treatment outcomes at a two-year interval. Materials and methods: This study evaluated 128 patients subjected to treatment cycles over a period of two years. Questionnaires were administered to the patients at the beginning and end of each cycle of iontophoretic therapy in order to monitor the degree of presumed anxiety, depression, pain and the associated quality of life. Result: This prospective descriptive observational study included 128 patients aged between 42 and 74 years presenting pain during erection and\/or coital intercourse, which ceased in 108 cases, diminished in 12 and remained present in 4. Concerning the penile deviation, which was present in all patients (128 cases), it disappeared in 6 cases, regressed in 90 cases, while it remained unchanged in 32 cases. As for the plaque consistency on palpation, in 42 patients the plaque was no longer present, in 50 cases the consistency diminished, while in 36 patients it remained unchanged. None of the cases evidenced an aggravation of the clinical condition. 57% of the evaluated patients had high levels of anxiety in the first cycle of iontophoretic sessions and low levels of depression. Anxiety decreased in 32% of cases. Depression was not related to pain but to sexual dysfunction. About 80 % of the patients assessed had an increase in quality of life at the end of the two-year follow-up. Conclusions: In conclusion, it can be claimed that iontophoresis combined with verapamil therapy can improve patients' quality of life and offer them psychophysical well-being and an acceptable sexual relationship, thus decreasing anxiety and depression levels.<\/jats:p>","DOI":"10.4081\/aiua.2022.1.75","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T13:58:17Z","timestamp":1648562297000},"page":"75-79","source":"Crossref","is-referenced-by-count":7,"title":["Quality of life of patients with La Peyronie's disease undergoing local iontophoresis therapy: A longitudinal observational study"],"prefix":"10.4081","volume":"94","author":[{"given":"Tatiana","family":"Bolgeo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Di Matteo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menada","family":"Gardalini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Gatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Maconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmelo","family":"Boccafoschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"49812","doi-asserted-by":"crossref","unstructured":"Mulhall JP, Alex B, Choi JM. Predicting delay in presentation in men with Peyronie\u2019s disease. J Sex Med. 2010;7:2226-30.","DOI":"10.1111\/j.1743-6109.2010.01785.x"},{"key":"49813","doi-asserted-by":"crossref","unstructured":"Paulis G, Romano G, Paulis L, Barletta D. Recent Pathophysiological Aspects of Peyronie\u2019s disease: role of free radicals, rationale, and therapeutic implications for antioxidant treatment-literature review. Adv Urol. 2017; 2017:4653512.","DOI":"10.1155\/2017\/4653512"},{"key":"49814","doi-asserted-by":"crossref","unstructured":"Di Maida F, Cito G, Lambertini L, et al. The natural history of Peyronie\u2019s disease. World J Mens Health. 2021; 39:399-405.","DOI":"10.5534\/wjmh.200065"},{"key":"49815","doi-asserted-by":"crossref","unstructured":"La Pera G, Pescatori ES, Calabrese M, et al. Peyronie\u2019s disease: prevalence and association with cigarette smoking. A multicenter population-based study in men aged 50-69 years. Eur Urol. 2001;40:525-30.","DOI":"10.1159\/000049830"},{"key":"49816","doi-asserted-by":"crossref","unstructured":"Bivalacqua TJ, Purohit SK, Hellstrom WJ. Peyronie\u2019s disease: advances in basic science and pathophysiology. Curr Urol Rep. 2000;1:297-301.","DOI":"10.1007\/s11934-000-0010-8"},{"key":"49817","doi-asserted-by":"crossref","unstructured":"Dibenedetti DB, Nguyen D, Zografos L, et al. A population-based study of Peyronie\u2019s disease: prevalence and treatment patterns in the United States. Adv Urol. 2011; 2011:282503.","DOI":"10.1155\/2011\/282503"},{"key":"49818","doi-asserted-by":"crossref","unstructured":"Montorsi F, Salonia A, Guazzoni G, et al. Transdermal electromotive multi-drug administration for Peyronie\u2019s disease: preliminary results. J Androl. 2000; 21:85-90.","DOI":"10.1002\/j.1939-4640.2000.tb03279.x"},{"key":"49819","doi-asserted-by":"crossref","unstructured":"Trost LW, Gur S, Hellstrom WJG. Pharmacological management of Peyronie\u2019s disease. Drugs. 2007; 67:527-45.","DOI":"10.2165\/00003495-200767040-00004"},{"key":"49820","doi-asserted-by":"crossref","unstructured":"Coyne KS, Currie BM, Thompson CL, Smith TM. The test-retest reliability of the Peyronie\u2019s disease questionnaire. J Sex Med. 2015;12:543-8.","DOI":"10.1111\/jsm.12769"},{"key":"49821","doi-asserted-by":"crossref","unstructured":"Coyne KS, Currie BM, Thompson CL, Smith TM. Responsiveness of the Peyronie\u2019s Disease Questionnaire (PDQ). J Sex Med. 2015;12:1072-9.","DOI":"10.1111\/jsm.12838"}],"container-title":["Archivio Italiano di Urologia e Andrologia"],"original-title":[],"link":[{"URL":"https:\/\/www.pagepressjournals.org\/index.php\/aiua\/article\/download\/aiua.2022.1.75\/9978","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepressjournals.org\/index.php\/aiua\/article\/download\/aiua.2022.1.75\/9978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T11:03:49Z","timestamp":1700391829000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pagepressjournals.org\/index.php\/aiua\/article\/view\/aiua.2022.1.75"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,29]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,3,29]]}},"URL":"https:\/\/doi.org\/10.4081\/aiua.2022.1.75","relation":{},"ISSN":["2282-4197","1124-3562"],"issn-type":[{"value":"2282-4197","type":"electronic"},{"value":"1124-3562","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3,29]]}}}