{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:28:15Z","timestamp":1787030895097,"version":"build-2736575974"},"reference-count":30,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>Objectives: The aim of this study is to investi-gate the association between the urinary metabolic milieu and kidney stone recurrence with a validated papillary evaluation score (PPLA).Materials and methods: We prospectively enrolled 30 stone for-mers who underwent retrograde intrarenal surgery procedures. Visual inspection of the accessible renal papillae was performed to calculate PPLA score, based on the characterization of ductal plugging, surface pitting, loss of papillary contour and Randall\u2019s plaque extension. Stone compositions, 24h urine collections and kidney stone events during follow-up were collected. Relative supersaturation ratios (RSS) for calcium oxalate (CaOx), brushite and uric acid were calculated using EQUIL-2. PPLA score &gt; 3 was de\ufb01ned as high.Results: Median follow-up period was 11 months (5, 34). PPLA score was inversely correlated with BMI (OR 0.59, 95% CI 0.38, 0.91, p = 0.018), type 2 diabetes (OR 0.04, 95% CI 0.003, 0.58, p = 0.018) and history of recurrent kidney stones (OR 0.17, 95%CI 0.04, 0.75, p = 0.019). The associations between PPLA score, diabetes and BMI were not con\ufb01rmed after excluding patients with uric acid stones. Higher PPLA score was associated with lower odds of new kidney stone events during follow-up (OR 0.15, 95% CI 0.02, 1.00, p = 0.05). No other signi\ufb01cant correla-tions were found.Conclusions: Our results con\ufb01rm the lack of ef\ufb01cacy of PPLA score in phenotyping patients affected by kidney stone disease or in predicting the risk of stone recurrence. Larger, long-term studies need to be performed to clarify the role of PPLA on the risk of stone recurrence.<\/jats:p>","DOI":"10.4081\/aiua.2023.10748","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T10:09:08Z","timestamp":1677060548000},"source":"Crossref","is-referenced-by-count":1,"title":["Determinants of renal papillary appearance in kidney stone formers: An in-depth examination"],"prefix":"10.4081","author":[{"given":"Matteo","family":"Bargagli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"De Leonardis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Ragonese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Totaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Recupero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Vittori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PierFrancesco","family":"Bassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Gambaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro Manuel","family":"Ferraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"key":"70537","doi-asserted-by":"crossref","unstructured":"Croppi E, Ferraro PM, Taddei L, Gambaro G, GEA Firenze Study Group. Prevalence of renal stones in an Italian urban population: a general practice-based study. Urol Res. 2012; 40:517-522.","DOI":"10.1007\/s00240-012-0477-z"},{"key":"70538","doi-asserted-by":"crossref","unstructured":"Lotan Y. Economics and cost of care of stone disease. Adv Chronic Kidney Dis. 2009; 16:5-10.","DOI":"10.1053\/j.ackd.2008.10.002"},{"key":"70539","doi-asserted-by":"crossref","unstructured":"Bargagli M, Tio MC, Waikar SS, Ferraro PM. Dietary Oxalate Intake and Kidney Outcomes. Nutrients. 2020; 12:2673.","DOI":"10.3390\/nu12092673"},{"key":"70540","doi-asserted-by":"crossref","unstructured":"Ferraro PM, Bargagli M, Trinchieri A, Gambaro G. Risk of Kidney Stones: In\ufb02uence of Dietary Factors, Dietary Patterns, and Vegetarian-Vegan Diets. Nutrients. 2020; 12:779.","DOI":"10.3390\/nu12030779"},{"key":"70541","doi-asserted-by":"crossref","unstructured":"Shavit L, Ferraro PM, Johri N, et al. Effect of being overweight on urinary metabolic risk factors for kidney stone formation. Nephrol Dial Transplant. 2015; 30:607-613.","DOI":"10.1093\/ndt\/gfu350"},{"key":"70542","doi-asserted-by":"crossref","unstructured":"Madore F, Stampfer MJ, Rimm EB, Curhan GC. Nephrolithiasis and risk of hypertension. Am J Hypertens. 1998; 11:46-53.","DOI":"10.1016\/S0895-7061(97)00371-3"},{"key":"70543","doi-asserted-by":"crossref","unstructured":"Taylor EN, Stampfer MJ, Curhan GC. Diabetes mellitus and the risk of nephrolithiasis. Kidney Int. 2005; 68:1230-1235.","DOI":"10.1111\/j.1523-1755.2005.00516.x"},{"key":"70544","doi-asserted-by":"crossref","unstructured":"Spatola L, Ferraro PM, Gambaro G, et al. Metabolic syndrome and uric acid nephrolithiasis: insulin resistance in focus. Metabolism 2018; 83:225-233.","DOI":"10.1016\/j.metabol.2018.02.008"},{"key":"70545","doi-asserted-by":"crossref","unstructured":"Gambaro G, Croppi E, Bushinsky D, et al. 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Endoscopic Evidence of Calculus Attachment to Randall\u2019s Plaque. J Urol. 2006; 175:1720-1724.","DOI":"10.1016\/S0022-5347(05)01017-7"},{"key":"70550","doi-asserted-by":"crossref","unstructured":"Borofsky MS, Paonessa JE, Evan AP, et al. A Proposed Grading System to Standardize the Description of Renal Papillary Appearance at the Time of Endoscopy in Patients with Nephrolithiasis. J Endourol. 2016; 30:122-127.","DOI":"10.1089\/end.2015.0298"},{"key":"70551","doi-asserted-by":"crossref","unstructured":"Werness PG, Brown CM, Smith LH, Finlayson B. EQUIL2: a BASIC computer program for the calculation of urinary saturation. J Urol. 1985; 134:1242-1244.","DOI":"10.1016\/S0022-5347(17)47703-2"},{"key":"70552","doi-asserted-by":"crossref","unstructured":"Cohen AJ, Borofsky MS, Anderson BB, et al. Endoscopic Evidence That Randall\u2019s Plaque is Associated with Surface Erosion of the Renal Papilla. 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