{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:55:19Z","timestamp":1790621719041,"version":"4.1.0"},"reference-count":59,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>\n\n\nObjective: To investigate a possible relationship between a history of congenital penile curvature (CPC) and Peyronie's disease (PD), and to characterize the psychological profile of patients suffering from PD, with or without concomitant CPC.\n\n\n\nMethods: We included 519 patients with Peyronie's disease (PD), of which 73 were found to have underlaying CPC. As a comparator population, we selected 2166 patients without PD, referring to our tertiary care clinic. In this population we detected 15 subjects with CPC. All patients completed the GAD-7 (Generalized-Anxiety-Disorder - 7 questions) and the PHQ-9 (Patient-Health-Questionnaire - 9 questions) questionnaires.\nResults: The overall prevalence of CPC in PD-patients was 14.07%, compared to a prevalence of 0.69% in the non-PD control population (p &lt; 0.00001). Moderate-to-severe anxiety was found to be present in 89.4% of all PD-patients.Significantly higher proportions of patients with CPC associated with PD showed severe anxiety, compared to patients with PD alone (57.5% vs. 36.7%, respectively, p = 0.0008). Moderate- severe depression was found to be present in 57.8% of all PD- patients. Significantly higher proportions of PD patients with a history of CPC showed severe depression, compared to patients with PD alone (13.6% vs. 3.36%, respectively, p &lt; 0.0002). GAD-7 median scores were significantly higher in patients with more severe penile curvatures (&gt; 45\u00b0; p = 0.029). We did not detect a statistically significant difference between PHQ-9 medi- an scores based on the severity of PD (p = 0.53). Analysis of PHQ-9 and GAD-7 median scores showed significantly worse depressive and anxious symptoms in younger patients(p &lt; 0.001 and p = 0.0013, respectively).\nConclusions: The presence of congenital-penile-curvature may represent a risk factor for the subsequent onset of Peyronie's disease. Moderate\/severe anxiety and moderate\/severe depression were reported in a high fraction of cases. Anxiety was significantly higher in patients with more severe penile-curvatures, and depression was present independently of the degree of penile curvature. Depression and anxiety were found to be more severe in younger subjects.\n\n\n\n\n\n<\/jats:p>","DOI":"10.4081\/aiua.2023.11238","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T14:30:59Z","timestamp":1678890659000},"source":"Crossref","is-referenced-by-count":5,"title":["Congenital penile curvature as a possible risk factor for the onset of Peyronie's disease, and psychological consequences of penile curvature"],"prefix":"10.4081","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7312-1514","authenticated-orcid":false,"given":"Gianni","family":"Paulis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Paulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianpaolo","family":"Perletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"72403","doi-asserted-by":"crossref","unstructured":"Hatzimouratidis K, Eardley I, Giuliano F, et al. 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Sex Med Rev. 2021; 9:340-349.","DOI":"10.1016\/j.sxmr.2020.01.005"},{"key":"72431","doi-asserted-by":"crossref","unstructured":"Chung E, Ralph D, Kagioglu A, et al. Evidence-based management guidelines on Peyronie's disease. J Sex Med. 2016; 13:905-923.","DOI":"10.1016\/j.jsxm.2016.04.062"},{"key":"72432","doi-asserted-by":"crossref","unstructured":"Nehra A, Alterowitz R, Culkin DJ, et al. Peyronie\u2019s disease: AUA guideline. J Urol. 2015; 194:745-753.","DOI":"10.1016\/j.juro.2015.05.098"},{"key":"72433","doi-asserted-by":"crossref","unstructured":"Osmonov D, Ragheb A, Ward S, et al. ESSM Position Statement on Surgical Treatment of Peyronie's Disease. Sex Med. 2022; 10:100459.","DOI":"10.1016\/j.esxm.2021.100459"},{"key":"72434","doi-asserted-by":"crossref","unstructured":"Tal R, Nabulsi O, Nelson CJ, et al. The psychosocial impact of penile reconstructive surgery for congenital penile deviation. 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