{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:04:02Z","timestamp":1777392242688,"version":"3.51.4"},"reference-count":15,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>Background: Para-testicular Rhabdomyosarcoma (PT-RMS) has a favorable treatment outcome adopting multidisciplinary management; resection, namely high inguinal orchiectomy \u00b1 retro-peritoneal lymph node dissection (RPLND) followed by standard or intensive chemotherapy \u00b1 adjuvant radiation therapy. Patients and methods: This is a retrospective study including all patients with pathologically proven PT-RMS, presented to the National Cancer Institute, Cairo University, during the period from 2005 to 2020. Endpoints included overall survival, disease free survival and patterns of failure of different treatment modalities. Results: Forty one patients were identified. Median age in our cohort was 15 years (range: 2-54 years). After a median follow up of 26 months (range, 3-75 months) ,two and five years OS were 100% and 91.7% respectively and median survival was not reached. Patients who underwent retro-peritoneal nodal dissection had a 5-year DFS rate of 100% versus 73% for those who received radiation to para-aortic nodes (p = 0.185). Limitations include retrospective nature and deviation from COG protocol. Conclusions: This study shows promising results suggesting that less aggressive local treatment modalities including radiation to para-aortic chain could be an option in PT-RMS, given the excellent results of this subtype. However further validation in a prospective study is warranted.<\/jats:p>","DOI":"10.4081\/aiua.2023.11642","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T15:42:15Z","timestamp":1700062935000},"source":"Crossref","is-referenced-by-count":3,"title":["Treatment results of Para-Testicular Rhabdomyosarcoma (PT-RMS) using radiation as an alternative to retro-peritoneal nodal dissection: A single Institution experience"],"prefix":"10.4081","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7807-6978","authenticated-orcid":false,"given":"Yasser A.","family":"Abdelazim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika F.","family":"Zaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen M.","family":"Abdel Mohsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3457-8735","authenticated-orcid":false,"given":"Reem M.","family":"Emad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9412-0251","authenticated-orcid":false,"given":"Heba G.","family":"Mohamad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8598-7128","authenticated-orcid":false,"given":"Dalia","family":"Abdelfatah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehab M.","family":"Kalil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"99812","doi-asserted-by":"crossref","unstructured":"Stewart LH, Lioe TF, Johnston SR. 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J Clin Oncol. 2001; 19:3091-3102.","DOI":"10.1200\/JCO.2001.19.12.3091"},{"key":"99818","doi-asserted-by":"crossref","unstructured":"Kumar R, Kapoor R, Khosla D, et al. Paratesticular rhabdomyosarcoma in young adults: A tertiary care institute experience. Indian J Urol. 2013; 29:110-3.","DOI":"10.4103\/0970-1591.114030"},{"key":"99819","doi-asserted-by":"crossref","unstructured":"Rogers TN, De Corti F, Burrieza GG, et al. Paratesticular rhabdomyosarcoma\u2014 impact of locoregional approach on patient outcome: a report from the European paediatric Soft tissue sarcoma Study Group (EpSSG). Pediatr Blood Cancer. 2020; 67:e28479.","DOI":"10.1002\/pbc.28479"},{"key":"99820","doi-asserted-by":"crossref","unstructured":"Heidenreich A, Albers P, Hartmann M, et al. Complications of primary nerve sparing retroperitoneal lymph node dissection for clinical stage I nonseminomatous germ cell tumors of the testis: experience of the German Testicular Cancer Study Group. 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