{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T12:07:42Z","timestamp":1747224462719,"version":"3.40.5"},"reference-count":13,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>Introduction: The study aimed to correlate the history of intravesical BCG as well as infantile BCG immunization with the incidence and severity of COVID-19 infection.\nMethods: Retrospective data collection of patients with high-risk non muscle invasive bladder cancer (NMIBC) from two Canadian centers. Data collection included a history of BCG instillation, infantile immunization, and the development of COVID-19 infection. Admission and\/ or mortality because of COVID-19 was reported.\nResults: We could include data from 348 patients: including 188 and 160 patients from Ontario and British Columbia respectively. COVID-19 affected 15% of these patients. Intravesical BCG was used in 44% of these patients. Intravesical BCG and\/or infantile BCG immunization did not correlate with the incidence of COVID-19 infection.\nConclusions: Previous intravesical BCG and\/ or a history of infantile BCG vaccination were not more\/ less frequent in patients who had COVID-19 infection.<\/jats:p>","DOI":"10.4081\/aiua.2024.12449","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T09:44:39Z","timestamp":1715247879000},"source":"Crossref","is-referenced-by-count":0,"title":["Does intravesical BCG for bladder cancer protect from COVID-19?"],"prefix":"10.4081","author":[{"given":"Anastasia","family":"MacDonald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lexia","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1047-7713","authenticated-orcid":false,"given":"Vahid","family":"Mehrnoush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livio","family":"Di Matteo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4582-9969","authenticated-orcid":false,"given":"Ahmed","family":"Zakaria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazem","family":"Elmansy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-7068","authenticated-orcid":false,"given":"Peter","family":"Black","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1484-1332","authenticated-orcid":false,"given":"Ahmed","family":"Kotb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"124536","doi-asserted-by":"crossref","unstructured":"Kaur G, Singh S, Nanda S, et al. Fiction and Facts about BCG Imparting Trained Immunity against COVID-19. Vaccines 2022; 10:1006.","DOI":"10.3390\/vaccines10071006"},{"key":"124537","doi-asserted-by":"crossref","unstructured":"Gong W, Aspatwar A, Wang S, et al. COVID-19 pandemic: SARS-CoV-2 specific vaccines and challenges, protection via BCG trained immunity, and clinical trials. Expert Rev Vaccines 2021; 20:857-880.","DOI":"10.1080\/14760584.2021.1938550"},{"key":"124538","unstructured":"Okafor CN, Rewane A, Momodu II. Bacillus Calmette Guerin. 2023 Jul 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024."},{"key":"124539","doi-asserted-by":"crossref","unstructured":"Koneru G, Batiha GE, Algammal AM, et al. BCG Vaccine-Induced Trained Immunity and COVID-19: Protective or Bystander? Infect Drug Resist. 2021; 14:1169-1184.","DOI":"10.2147\/IDR.S300162"},{"key":"124540","doi-asserted-by":"crossref","unstructured":"Miyasaka M. Is BCG vaccination causally related to reduced COVID-19 mortality? EMBO Mol Med. 2020; 12:e12661.","DOI":"10.15252\/emmm.202012661"},{"key":"124541","doi-asserted-by":"crossref","unstructured":"Saginala K, Barsouk A, Aluru JS, et al. Epidemiology of Bladder Cancer. Med Sci (Basel). 2020; 8:15.","DOI":"10.3390\/medsci8010015"},{"key":"124542","doi-asserted-by":"crossref","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (San Diego, Calif.), 2001; 25:402-408.","DOI":"10.1006\/meth.2001.1262"},{"key":"124543","doi-asserted-by":"crossref","unstructured":"Gallegos H, Rojas PA, Sep\u00falveda F, et al. Protective role of intravesical BCG in COVID-19 severity. BMC Urology, 2021; 21:50.","DOI":"10.1186\/s12894-021-00823-6"},{"key":"124544","doi-asserted-by":"crossref","unstructured":"van Puffelen JH, Novakovic B, van Emst L, et al. Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections. J Immunother Cancer. 2023; 11:e005518.","DOI":"10.1136\/jitc-2022-005518"},{"key":"124545","doi-asserted-by":"crossref","unstructured":"Pichler R, Diem G, Hackl H, et al. Intravesical BCG in bladder cancer induces innate immune responses against SARS CoV-2. Front. Immunol. 2023; 14:1202157.","DOI":"10.3389\/fimmu.2023.1202157"},{"key":"124546","doi-asserted-by":"crossref","unstructured":"Miller A, Reandelar MJ, Fasciglione K, et al. (2020). Correlation between Universal BCG Vaccination Policy and Reduced Mortality for COVID-19. MedRxiv preprint doi: https:\/\/doi.org\/10.1101\/2020.03.24.20042937","DOI":"10.1101\/2020.03.24.20042937"},{"key":"124547","doi-asserted-by":"crossref","unstructured":"World Health Organization (2020). Bacille Calmette-Gu\u00e9rin (BCG) vaccination and Covid-19. https:\/\/www.who.int\/newsroom\/commentaries\/detail\/bacille-calmette-gu%E9rin-(bcg)-vaccination-and-covid-19","DOI":"10.15557\/PiMR.2020.0025"},{"key":"124548","unstructured":"Travassos TC, De Oliveira JMI, Selegatto IB, Reis LO. COVID-19 impact on bladder cancer-orientations for diagnosing, decision making, and treatment. Am J Clin Exp Urol. 2021; 9:132-139."}],"container-title":["Archivio Italiano di Urologia e Andrologia"],"original-title":[],"link":[{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/download\/12449\/11955","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/download\/12449\/11955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T09:44:47Z","timestamp":1715247887000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/view\/12449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,9]]},"references-count":13,"URL":"https:\/\/doi.org\/10.4081\/aiua.2024.12449","relation":{},"ISSN":["2282-4197","1124-3562"],"issn-type":[{"type":"electronic","value":"2282-4197"},{"type":"print","value":"1124-3562"}],"subject":[],"published":{"date-parts":[[2024,5,9]]}}}