{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T05:13:33Z","timestamp":1737782013058,"version":"3.33.0"},"reference-count":0,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>Objectives: This research aimed to compare the prostate cancer (PCa) features, survival rate, and functional outcomes after open suprapubic Radical Prostatectomy (RP) between younger men (\u2264 55 years) and older men (&gt; 55 years).Methods:  In this retrospective cohort study, we studied 134 patients with clinically localized PCa who underwent RP at our centers between 2011 and 2019, with 26 (19.40%) patients aged \u2264 55. Pathological parameters, survival rate (at 5 and 10 years), and functional outcomes such as erectile function and continence rate (at two years from RP) were evaluated retrospectively, and the two groups were compared. The Chi-square test, Kaplan-Meier, and Cox proportional hazards method were used for statistical analysis.Results: Men aged \u2264 55 had greater rates of organ-confined tumors, lower D'Amico risk grouping, and pathologic Gleason grade than their older counterparts (all p&lt;0.05). The median follow-up was 81 months. The overall survival rate at five and ten years in younger men vs older counterparts was 96.15% vs. 93.47% and 92.15% v. 82.13% but was not statistically significant (p=0.1539). Five-year biochemical recurrence-free and metastasis-free survival rates in younger men vs older counterparts were 96.2% vs 81.5% and 75.7% vs\u00a051.5%. Men &gt; 55 years were associated with worse BCR-free and metastasis-free survival in univariate analysis and worsening BCR in multivariate analysis. The continence rate was significantly improved in men aged \u2264 55 years compared to older counterparts (OR: 5.08; 95% CI: 1.61-22.61; p=0.013). However, erectile function was not statistically significant between groups [for moderate ED: (OR:1.08; 95% CI: 0.43-2.79, p=0.865), for severe ED (OR: 1.60; 95% CI: 0.35-11.50, p=0.579=)].Conclusions: Our study showed that survival rates were similar in younger men (\u2264 55 years) and their older counterparts. However, older patients who underwent RP had more advanced disease, worse BCR-free survival, and worse continence rate. For localized prostate cancer patients under 55 years of age, radical prostatectomy is an excellent treatment option with excellent long-term survival results. Given the relatively\u00a0small number of patients younger than 55, a large cohort study with long-term postprocedural follow-up is needed to validate this observation.<\/jats:p>","DOI":"10.4081\/aiua.2025.12658","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T10:57:41Z","timestamp":1737716261000},"source":"Crossref","is-referenced-by-count":0,"title":["Survival and oncological outcomes for young men (\u2264 55 years) undergoing radical prostatectomy for localized prostate cancer"],"prefix":"10.4081","author":[{"given":"Shahryar","family":"Zeighami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ariafar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Makarem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7188-2715","authenticated-orcid":false,"given":"Faisal","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5702-4036","authenticated-orcid":false,"given":"Mohammadreza","family":"Askarpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2025,1,23]]},"container-title":["Archivio Italiano di Urologia e Andrologia"],"original-title":[],"link":[{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/download\/12658\/12765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/download\/12658\/12765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T10:57:42Z","timestamp":1737716262000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/view\/12658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4081\/aiua.2025.12658","relation":{},"ISSN":["2282-4197","1124-3562"],"issn-type":[{"value":"2282-4197","type":"electronic"},{"value":"1124-3562","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,23]]}}}