{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T11:13:23Z","timestamp":1737630803661,"version":"3.33.0"},"reference-count":0,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>Background: Varicocele (Vx) which is the most treatable cause of male infertility, is also associated with low sperm count, decreased sperm motility and increased sperm abnormal morphology. We aimed in the current study to evaluate the correlation between seminal \u03b1-Glycerylphosphorylcholine (\u03b1GPC) and semen parameters in infertile patients pre- and post- sub-inguinal micro-varicocelectomy.Methods: The current comparative prospective study was carried out on 20 male patients who presented to Kasr Al-Ainy\u00a0Hospitals from March 2022 to March 2023 as well as 20 healthy controls. The participants were divided into groups as follows: group (1) included fertile normozoospermic men (n = 20) who served as controls. Group (2) included infertile oligoasthenoteratozoospermia (OAT) men with varicocele (n = 20). Patients in group (2) were followed up to 3 months after microsurgical\u00a0sub-inguinal Varicocelectomy. The examination included an assessment of Vx with scrotal Duplex. Semen analysis was\u00a0done according to the 5th\u00a0Edition of WHO manual for semen\u00a0analysis.Results: The study demonstrates that \u03b1GPC level was significantly higher among fertile normozoospermic control group and\u00a0infertile OAT men post varicocelectomy when compared to infertile OAT men preoperative (p&lt;0.001). Moreover, it demonstrates that on follow up of infertile OAT group 3 months after sub-inguinal micro-varicocelectomy, all semen parameters\u00a0showed significant improvement compared to the corresponding semen parameters pre-operatively among Vxs grade II and\u00a0grade III (p&lt;0.001, p&lt;0.001, respectively). A significant positive correlation was found between \u03b1GPC level and semen parameters including sperm normal forms, sperm count and\u00a0sperm motility. Using ROC curve, \u03b1GPC protein showed a sensitivity of (100%) and a specificity of (100%) at cut off value\u00a0(\u2264 1.975 pg\/ml) in differentiation between infertile OAT patients with Vx and control fertile normozoospermic men (p&lt;0.001). Conclusions: \u03b1GPC may play an important role in infertility in men with Vx and correction of Vx improves the seminal \u03b1GPC level.<\/jats:p>","DOI":"10.4081\/aiua.2025.12832","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T10:56:43Z","timestamp":1737629803000},"source":"Crossref","is-referenced-by-count":0,"title":["Correlation between seminal \u03b1-glycerylphosphorylcholine and semen parameters in infertile patients pre- and post sub-inguinal micro-varicocelectomy: a prospective study"],"prefix":"10.4081","author":[{"given":"Ahmed Fathy","family":"Aboseif","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nashaat","family":"Nabil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameh Fayek","family":"GamalEl Din","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaimaa","family":"Abdelkareem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya Ahmed","family":"Onsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4725-8557","authenticated-orcid":false,"given":"Ahmad","family":"Zaghloul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amgad","family":"Elseginy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2025,1,23]]},"container-title":["Archivio Italiano di Urologia e Andrologia"],"original-title":[],"link":[{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/download\/12832\/12766","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/download\/12832\/12766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T10:56:44Z","timestamp":1737629804000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/view\/12832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4081\/aiua.2025.12832","relation":{},"ISSN":["2282-4197","1124-3562"],"issn-type":[{"value":"2282-4197","type":"electronic"},{"value":"1124-3562","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,23]]}}}