{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T20:45:48Z","timestamp":1789937148758,"version":"4.0.1"},"reference-count":9,"publisher":"PAGEPress Publications","issue":"2","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>Introduction: Cryptorchidism or undescended testis (UDT) is one of the most common congenital anomalies in male infants. Based on the physical examination, UDT can be classified into palpable and non-palpable. However, despite successful repositioning, the long-term function of the testis is still a concern. This meta-analysis aims to compare the testicular function of palpable UDT and non-palpable UDT post-orchidopexy using hormonal markers such as FSH, LH, and testosterone. Materials and methods: A comprehensive literature search was performed using PubMed, ScienceDirect, and Google Scholar databases up to March 2025. Statistical analyses were conducted using Review Manager (RevMan). Results: Four eligible studies were included in the analysis, involving 207 patients who underwent orchidopexy for UDT, including 160 with palpable UDT and 47 with non-palpable UDT. There is no significant difference between palpable compared to non-palpable in terms of FSH (MD 0.78 IU\/L [95% CI: -0.34 to 1.90], p = 0.14); LH (MD -0.17 IU\/L [95% CI: -0.45 to 0.12], p = 0.25); and testosterone (-0.08 IU\/L [95% CI: -0.64 to 0.48], p = 0.78).Conclusions: Testicular functions, including FSH, LH, and testosterone, in palpable UDT did not differ significantly from those in non-palpable UDT.<\/jats:p>","DOI":"10.4081\/aiua.2025.13903","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T06:42:29Z","timestamp":1751265749000},"source":"Crossref","is-referenced-by-count":1,"title":["Evaluating hormonal differences in post-orchidopexy patients: a meta-analysis of palpable &lt;i&gt;vs.&lt;\/i&gt; nonpalpable undescended testis"],"prefix":"10.4081","volume":"97","author":[{"given":"Marshal Harvy Wicaksono","family":"Pantjoro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6388-7581","authenticated-orcid":false,"given":"Anak Agung Ngurah Krisnanta","family":"Adnyana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gede Wirya Kusuma","family":"Duarsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"184377","doi-asserted-by":"crossref","unstructured":"Liu J, Xiu W, Sui B, et al. Open controversies on the treatment of undescended testis: An update. Front Pediatr. 2022; 10:874995.","DOI":"10.3389\/fped.2022.874995"},{"key":"184378","doi-asserted-by":"crossref","unstructured":"Rodprasert W, Virtanen HE, Toppari J. Cryptorchidism and puberty. Front Endocrinol (Lausanne). 2024; 15:1347435.","DOI":"10.3389\/fendo.2024.1347435"},{"key":"184379","doi-asserted-by":"crossref","unstructured":"Chiba K, Ishikawa T, Yamaguchi K, Fujisawa M. The efficacy of adult orchidopexy as a treatment of male infertility: our experience of 20 cases. Fertil Steril. 2009; 92:1337-9.","DOI":"10.1016\/j.fertnstert.2009.03.104"},{"key":"184380","doi-asserted-by":"crossref","unstructured":"Lee PA, Coughlin MT, Bellinger MF. Paternity and hormone levels after unilateral cryptorchidism: association with pretreatment testicular location. J Urol. 2000;164:1697-701.","DOI":"10.1016\/S0022-5347(05)67087-5"},{"key":"184381","doi-asserted-by":"crossref","unstructured":"Walczak-Jedrzejowska R, Niedzielski J, Slowikowska-Hilczer J, et al. Hormonal function of undescended testes before orchidopexy in prepubertal boys. J Clin Med. 2024; 14:73.","DOI":"10.3390\/jcm14010073"},{"key":"184382","doi-asserted-by":"crossref","unstructured":"Sangster P, Alnajjar HM, Ahmed K, et al. Microdissection TESE (mTESE) following adult orchidopexy for undescended intra-abdominal and inguinal testicles \u2013 surgical techniques and outcomes from a single-centre cohort. Andrology. 2020;8:166-70.","DOI":"10.1111\/andr.12679"},{"key":"184383","doi-asserted-by":"crossref","unstructured":"Trsinar B, Muravec UR. Fertility potential after unilateral and bilateral orchidopexy for cryptorchidism. World J Urol. 2009;27:513-9.","DOI":"10.1007\/s00345-009-0406-0"},{"key":"184384","unstructured":"American Urological Association. Evaluation and treatment of cryptorchidism (2018). Accessed: 2025 Mar 25. Available from: https:\/\/www.auanet.org\/guidelines-and-quality\/guidelines\/cryptorchidism-guideline"},{"key":"184385","unstructured":"Uroweb [Internet]. EAU Guidelines on paediatric urology - Accessed: 2025 Mar 25. Available from: https:\/\/uroweb.org\/guidelines\/paediatric-urology\/chapter\/citation-information"}],"container-title":["Archivio Italiano di Urologia e Andrologia"],"original-title":[],"link":[{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/download\/13903\/13195","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/download\/13903\/13195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T06:42:35Z","timestamp":1751265755000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/view\/13903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6,30]]}},"URL":"https:\/\/doi.org\/10.4081\/aiua.2025.13903","relation":{},"ISSN":["2282-4197","1124-3562"],"issn-type":[{"value":"2282-4197","type":"electronic"},{"value":"1124-3562","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}