{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:25:59Z","timestamp":1763018759238,"version":"3.41.0"},"reference-count":15,"publisher":"PAGEPress Publications","issue":"2","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>Introduction: Cryptorchidism, or undescended testis (UDT), is a congenital anomaly linked to an increased risk of infertility. The laterality of UDT, whether unilateral or bilateral, may influence post-orchidopexy outcomes. This meta-analysis compares testicular function and azoospermia rates between patients with bilateral and unilateral UDT post-orchiopexy. Materials and methods: A comprehensive literature search was performed using PubMed, ScienceDirect, and Google Scholar databases up to March 2025. Statistical analyses were conducted using Review Manager (RevMan). Results: Ten eligible studies were included in the analysis, comprising 563 bilateral UDT post-orchidopexy and 1259 unilateral UDT post-orchidopexy cases. Populations post bilateral orchidopexy have significantly higher FSH level (MD: 3.77 UI\/L [95% CI: 1.65 - 5.89]), significantly higher LH level (MD: 1.27 UI\/L [95% CI: 0.27 - 2.26]), lower inhibin B level (MD: -44.86 pg\/mL [95% CI: -69.58 - -20.15]), and higher frequency of azoospermia (OR 2.3 [95% CI: 1.57 - 3.37]) compared to unilateral UDT post orchidopexy. Conclusions: Bilateral UDT post-orchidopexy exhibits poorer testicular function with significantly higher FSH and LH levels, reduced inhibin B levels, and a greater incidence of azoospermia compared to unilateral UDT post-orchidopexy.<\/jats:p>","DOI":"10.4081\/aiua.2025.13918","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T06:42:29Z","timestamp":1751265749000},"source":"Crossref","is-referenced-by-count":1,"title":["Does bilateral undescended testis have worst testicular function than unilateral cases? A meta-analysis of adult orchidopexy patients"],"prefix":"10.4081","volume":"97","author":[{"given":"Anak Agung Ngurah Krisnanta","family":"Adnyana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0418-9834","authenticated-orcid":false,"given":"Marshal Harvy Wicaksono","family":"Pantjoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gede Wirya Kusuma","family":"Duarsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"184352","doi-asserted-by":"crossref","unstructured":"Liu J, Xiu W, Sui B, et al. Open controversies on the treatment of undescended testis: An update. Front Pediatr. 2022; 10:874995.","DOI":"10.3389\/fped.2022.874995"},{"key":"184353","doi-asserted-by":"crossref","unstructured":"Averous M, Lopez C. La cryptorchidie: le point de vue de l'urologuep\u00e9diatre [Cryptorchidism: the point of view of a pediatric urologist]. Gynecol Obstet Fertil. 2004; 32:813-817.","DOI":"10.1016\/j.gyobfe.2004.07.012"},{"key":"184354","doi-asserted-by":"crossref","unstructured":"Rodprasert W, Virtanen HE, Toppari J. Cryptorchidism and puberty. Front Endocrinol (Lausanne) 2024; 15:1347435.","DOI":"10.3389\/fendo.2024.1347435"},{"key":"184355","doi-asserted-by":"crossref","unstructured":"Fan L, Shi L, Liu S, et al. Bilateral versus unilateral orchidopexy: IVF\/ICSI-ET outcomes. Front Endocrinol (Lausanne) 2024;15:1294884.","DOI":"10.3389\/fendo.2024.1294884"},{"key":"184356","doi-asserted-by":"crossref","unstructured":"Ozan T, Karakeci A, Kaplancan T, et al. Are predictive factors in sperm retrieval and pregnancy rates present in nonobstructive azoospermia patients by microdissection testicular sperm extraction on testicle with a history of orchidopexy operation? Andrologia 2019; 51:e13430.","DOI":"10.1111\/and.13430"},{"key":"184357","doi-asserted-by":"crossref","unstructured":"van Brakel J, Kranse R, de Muinck Keizer-Schrama SM, et al. Fertility potential in men with a history of congenital undescended testes: a long-term follow-up study. Andrology. 2013; 1:100-108.","DOI":"10.1111\/j.2047-2927.2012.00024.x"},{"key":"184358","doi-asserted-by":"crossref","unstructured":"Trsinar B, Muravec UR. Fertility potential after unilateral and bilateral orchidopexy for cryptorchidism. World J Urol. 2009; 27:513-519.","DOI":"10.1007\/s00345-009-0406-0"},{"key":"184359","doi-asserted-by":"crossref","unstructured":"Chiba K, Ishikawa T, Yamaguchi K, Fujisawa M. The efficacy of adult orchidopexy as a treatment of male infertility: our experience of 20 cases. Fertil Steril. 2009; 92:1337-1339.","DOI":"10.1016\/j.fertnstert.2009.03.104"},{"key":"184360","doi-asserted-by":"crossref","unstructured":"Lee PA, Coughlin MT. Fertility after bilateral cryptorchidism. Evaluation by paternity, hormone, and semen data. Horm Res. 2001;55:28-32.","DOI":"10.1159\/000049960"},{"key":"184361","doi-asserted-by":"crossref","unstructured":"Rusnack SL, Wu HY, Huff DS, et al. Testis histopathology in boys with cryptorchidism correlates with future fertility potential. J Urol. 2003;169:659-662.","DOI":"10.1016\/S0022-5347(05)63986-9"},{"key":"184362","doi-asserted-by":"crossref","unstructured":"Rohayem J, Luberto A, Nieschlag E, et al. Delayed treatment of undescended testes may promote hypogonadism and infertility. Endocrine. 2017; 55:914-924.","DOI":"10.1007\/s12020-016-1178-0"},{"key":"184363","doi-asserted-by":"crossref","unstructured":"Barbotin AL, Dauvergne A, Dumont A, et al. Bilateral versus unilateral cryptorchidism in nonobstructive azoospermia: Testicular sperm extraction outcomes. Asian J Androl. 2019; 21:445-451.","DOI":"10.4103\/aja.aja_2_19"},{"key":"184364","doi-asserted-by":"crossref","unstructured":"Kraft KH, Canning DA, Snyder HM, Kolon TF. Undescended testis histology correlation with adult hormone levels and semen analysis. J Urol. 2012;188:S1429-35.","DOI":"10.1016\/j.juro.2012.04.025"},{"key":"184365","doi-asserted-by":"crossref","unstructured":"Esposito S, Cofini M, Rigante D, et al. Inhibin B in healthy and cryptorchid boys. Ital J Pediatr. 2018; 44:81.","DOI":"10.1186\/s13052-018-0523-8"},{"key":"184366","doi-asserted-by":"crossref","unstructured":"Corinne TM, Anatole PC, Jeanne NY. Comparison of serum inhibin B and follicle-stimulating hormone (FSH) level between normal and infertile men in Yaound\u00e9. Int J Reprod Med. 2020;2020:4765809.","DOI":"10.1155\/2020\/4765809"}],"container-title":["Archivio Italiano di Urologia e Andrologia"],"original-title":[],"link":[{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/download\/13918\/13194","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/download\/13918\/13194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T06:42:36Z","timestamp":1751265756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/view\/13918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6,30]]}},"URL":"https:\/\/doi.org\/10.4081\/aiua.2025.13918","relation":{},"ISSN":["2282-4197","1124-3562"],"issn-type":[{"value":"2282-4197","type":"electronic"},{"value":"1124-3562","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}