{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T14:48:24Z","timestamp":1779202104707,"version":"3.51.4"},"reference-count":34,"publisher":"PAGEPress Publications","issue":"4","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>Introduction: To evaluate the use of urethral drug-coated balloon (DCB) in the treatmentof recurrent urethral strictures.Materials and methods: From January 2023 to June 2025, twenty males (median 69 years) with recurrent urethral strictures were evaluated: 7\/20 (35%) had urethral-bladder neck stenosis following radical prostatectomy, 11\/20 (55%) and 2\/20 (10%) had bulbar and anterior stenosis. All the patients previously underwent in 19\/20 cases endoscopic urethrotomy (1-3 times) and in one case urethroplasty for hyospadias; median flow max was 5\/ml\/sec and post voiding urine residual was 150 ml; one man had suprapubic catheter. Urethral stenosis was measured by ultrasound (US) using saline water injected through the external meatus; moreover, US guided urethral dilatation was performed. Strictures were pretreated with an uncoated balloon or by stenosis incision; the inflation of Optilume\u00ae \u00a0DCB occurred for 7 min to allow complete stricture dilation and paclitaxel delivery. Finally a 18 Ch catheter was allocated in the bladder and removed five days later. Clinical outcomes included: average Qmax, International Prostate Symptoms Score (IPSS), IPSS quality of life (QoL), International Index of Erectile Function (IEFF-5) and over time rate of repeated intervention (dilation, endoscopic urethrotomy or urethroplasty).Results: None had side effects during and following the procedure; all the patients improved their IPSS, IEEF-5 and none underwent repeated urethral treatment during the follow up. QoL improved together with sexual activity; although, IPPS score and flow max were improved but not restored to normal values all the patients had a good QoL refusing additional instrumental evaluation during the follow up. In detail, at a median 12 months of follow up IPSS, QoL and post-voiding urine residual and IEEF-score improved of 63%, 60%, 78% and 50%, respectively.Conclusions: Although the limited number of patients evaluated and follow up, DCB demonstrated a good alternative for men with anterior and posterior urethral stenosis who have an unsuccessful endoscopic urethrotomy or dilation who want to avoid urethroplasty.<\/jats:p>","DOI":"10.4081\/aiua.2025.14248","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:48:44Z","timestamp":1761569324000},"source":"Crossref","is-referenced-by-count":1,"title":["Ultrasound guided urethral drug-coated balloon treatment: our experience in 20 men"],"prefix":"10.4081","volume":"97","author":[{"given":"Pietro","family":"Pepe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Candiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letterio","family":"D'Arrigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"200189","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.82984"},{"key":"200190","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2021.06.022"},{"key":"200191","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.6661"},{"key":"200192","doi-asserted-by":"publisher","DOI":"10.1002\/bco2.312"},{"key":"200193","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002346"},{"key":"200194","doi-asserted-by":"publisher","DOI":"10.1159\/000082703"},{"key":"200195","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2025.156040"},{"key":"200196","doi-asserted-by":"publisher","DOI":"10.4081\/aiua.2024.12992"},{"key":"200197","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11010010"},{"key":"200198","doi-asserted-by":"publisher","DOI":"10.4081\/aiua.2023.11322"},{"key":"200199","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13254"},{"key":"200200","doi-asserted-by":"publisher","DOI":"10.1159\/000100833"},{"key":"200201","unstructured":"13. 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