{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T12:50:27Z","timestamp":1782737427652,"version":"3.54.5"},"reference-count":20,"publisher":"PAGEPress Publications","issue":"2","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>Objective: This study aims to evaluate the initial safety and efficacy of Holmium enucleation of the prostate (HoLEP) in managing benign prostatic hypertrophy (BPH) in a single tertiary centre. \nMaterials &amp; methods :A retrospective cohort study was conducted focusing on a single tertiary hospital in which data was collected from electronic medical records which includes demographic information, preoperative characteristics, surgical details, and post-operative outcomes; complications were classified using the Clavien-Dindo classification.\nResults: 104 patients with BPH and lower urinary tract symptoms (LUTS) were analysed in this study, with a mean prostate volume of 109.3 \u00b1 47.2 ml. The mean change in post void residual volume (PVR) was (-)75%, whilst the mean change in maximum flow rate (QMax) was (+)109%. 21\/104 (19%) patients presented with post-operative complications, the majority of these (13) were Grade I complications with three patients being Grade III. Increasing age (p = 0.014) was shown to have contributed to complications. Pre-operative anticoagulation was shown to yield no significance (p = 0.066).\nConclusion: HoLEP remains a viable treatment modality for BPH especially in larger prostates (&gt; 100 ml). However, considerations regarding post-operative outcomes should be taken when offering this treatment to more elderly patients. Additionally, HoLEP provides a good treatment option for patients on anticoagulation.<\/jats:p>","DOI":"10.4081\/aiua.2026.14705","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:54Z","timestamp":1778284854000},"source":"Crossref","is-referenced-by-count":0,"title":["Initial safety and efficacy of holmium laser enucleation of the prostate: real world evidence from a tertiary centre"],"prefix":"10.4081","volume":"98","author":[{"given":"Sailantra","family":"Sivathasan","sequence":"first","affiliation":[{"name":"NHS Tayside Ninewells Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lit Kiat","family":"Tan","sequence":"additional","affiliation":[{"name":"NHS Tayside Ninewells Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brayan","family":"Samuel","sequence":"additional","affiliation":[{"name":"Univeristy of Dundee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrarajan","family":"Shah","sequence":"additional","affiliation":[{"name":"NHS Lothian Western General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chigozie","family":"Onyeze","sequence":"additional","affiliation":[{"name":"NHS Tayside Ninewells Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Kalpee","sequence":"additional","affiliation":[{"name":"NHS Tayside Ninewells Hospital; University of Dundee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"228905","unstructured":"1. National Institute for Health and Care Excellence (NICE). Lower urinary tract symptoms in men: assessment and management (Internet). London: NICE; 2010 (updated 2015; cited 2025 Feb 28)."},{"key":"228906","doi-asserted-by":"crossref","unstructured":"2. Djavan B, Chapple C, Milani S, Marberger M. State of the art on the efficacy and tolerability of alpha1-adrenoceptor antagonists in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia. Urology. 2004; 64:1081-8.","DOI":"10.1016\/j.urology.2004.07.031"},{"key":"228907","doi-asserted-by":"crossref","unstructured":"3. Tan A, Liao C, Mo Z, Cao Y. Meta-analysis of holmium laser enucleation versus transurethral resection of the prostate for symptomatic prostatic obstruction. Br J Surg. 2007; 94:1201-8.","DOI":"10.1002\/bjs.5916"},{"key":"228908","doi-asserted-by":"crossref","unstructured":"4. Elmansy HM, Kotb A, Elhilali MM. Holmium laser enucleation of the prostate: long-term durability of clinical outcomes and complication rates during 10 years of followup. J Urol. 2011; 186:1972-6.","DOI":"10.1016\/j.juro.2011.06.065"},{"key":"228909","doi-asserted-by":"crossref","unstructured":"5. Cornu JN, Ahyai S, Bachmann A, et al. A Systematic Review and Meta-analysis of Functional Outcomes and Complications Following Transurethral Procedures for Lower Urinary Tract SymptomsnResulting from Benign Prostatic Obstruction: An Update. Eur Urol 2015; 67:1066-1096.","DOI":"10.1016\/j.eururo.2014.06.017"},{"key":"228910","doi-asserted-by":"crossref","unstructured":"6. Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004; 240:205-13.","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"228911","doi-asserted-by":"crossref","unstructured":"7. Ahyai SA, Gilling P, Kaplan SA, et al. Meta-analysis of functional outcomes and complications following transurethral procedures for lower urinary tract symptoms resulting from benign prostatic enlargement. Eur Urol. 2010; 58:384-97.","DOI":"10.1016\/j.eururo.2010.06.005"},{"key":"228912","doi-asserted-by":"crossref","unstructured":"8. Cornu JN, Ahyai S, Bachmann A, de la Rosette J, et al. A Systematic Review and Meta-analysis of Functional Outcomes and Complications Following Transurethral Procedures for Lower Urinary Tract Symptoms Resulting from Benign Prostatic Obstruction: An Update. Eur Urol. 2015; 67:1066-1096","DOI":"10.1016\/j.eururo.2014.06.017"},{"key":"228913","unstructured":"9. Gilling PJ, Kennett K M, Fraundorfer MR, & Holmium Study Group. Holmium laser enucleation of the prostate (HoLEP) versus transurethral resection of the prostate (TURP) in a prospective randomized trial with 2-year follow-up. J Endourol 2012; 26: 343-349"},{"key":"228914","unstructured":"10. Shah HN, Mahajan AP, Hegde SS, & Mahajan AS. Perioperative outcomes of holmium laser enucleation of prostate in patients on anticoagulant therapy: A comparative study. J Endourol 2016; 30:850-855."},{"key":"228915","doi-asserted-by":"crossref","unstructured":"11. El Tayeb MM, Jacob JM, Bhojani N, et al. Holmium Laser Enucleation of the Prostate in Patients Requiring Anticoagulation. J Endourol. 2016; 30:805-9.","DOI":"10.1089\/end.2016.0070"},{"key":"228916","doi-asserted-by":"crossref","unstructured":"12. Naspro R, Suardi N, Salonia A, et al. Holmium laser enucleation of the prostate versus open prostatectomy for prostates > 70 g: 24- month follow-up. Eur Urol. 2006; 50:563-8.","DOI":"10.1016\/j.eururo.2006.04.003"},{"key":"228917","doi-asserted-by":"crossref","unstructured":"13. Elsaqa M, Zhang Y, El M. MP51-07 Impact of Age and frailty on surgical outcomes of Holmium laser enucleation of prostate (HoLEP) in nonagenarians and octagenarians patients. J Urol. 2023; 209(Suppl 4):e695.","DOI":"10.1097\/JU.0000000000003299.07"},{"key":"228918","unstructured":"14. Placer J, Gelabert-Mas A, Vallmanya F, et al. Holmium laser enucleation of the prostate: Outcome and complications of self-taught learning curve. World J Urol 2016; 34:555-562."},{"key":"228919","unstructured":"15. Montorsi F, Naspro R, Salonia A, et al. Holmium laser enucleation of the prostate for benign prostatic hyperplasia: indications and techniques. Journal of Endourology. 2016; 30:115-121."},{"key":"228920","doi-asserted-by":"crossref","unstructured":"16. Mmeje CO, Nunez-Nateras R, Warner JN, Humphreys MR. Age-stratified outcomes of holmium laser enucleation of the prostate. BJU Int. 2013; 112:982-9.","DOI":"10.1111\/bju.12063"},{"key":"228921","unstructured":"17. Rieken M, Cornu JN, Gilling P, et al. Risk factors for intraoperative complications in patients undergoing prostate enucleation with holmium laser: results from a large international multicentre study. World Journal of Urology. 2014; 32:421-427."},{"key":"228922","doi-asserted-by":"crossref","unstructured":"18. Nam JK, Kim HW, Lee DH, et al. Risk Factors for Transient Urinary Incontinence after Holmium Laser Enucleation of the Prostate. World J Mens Health. 2015; 33:88-94.","DOI":"10.5534\/wjmh.2015.33.2.88"},{"key":"228923","doi-asserted-by":"crossref","unstructured":"19. Roper C, Slade A, Caras R, et al. Ejaculatory and erectile function outcomes following holmium laser enucleation of the prostate. Prostate. 2024; 84:791-796.","DOI":"10.1002\/pros.24697"},{"key":"228924","doi-asserted-by":"crossref","unstructured":"20. Savin Z, Dekalo S, Herzberg H, et al. Improving Prostatic Preoperative Volume Estimation and Planning before Laser Enucleation. J Pers Med. 2022; 12:1761.","DOI":"10.3390\/jpm12111761"}],"container-title":["Archivio Italiano di Urologia e Andrologia"],"original-title":[],"link":[{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/download\/14705\/14081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/download\/14705\/14081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T12:41:23Z","timestamp":1782736883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/view\/14705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6,29]]}},"URL":"https:\/\/doi.org\/10.4081\/aiua.2026.14705","relation":{},"ISSN":["2282-4197","1124-3562"],"issn-type":[{"value":"2282-4197","type":"electronic"},{"value":"1124-3562","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,8]]}}}