{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:37:59Z","timestamp":1791999479273,"version":"4.4.0"},"reference-count":95,"publisher":"PAGEPress Publications","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>Background: Peyronie\u2019s disease (PD) impacts the penile albuginea, leading to deformity,\u00a0pain, erectile dysfunction (ED), and an anxious-depressive state. Diagnosis of PD involves taking a detailed medical history;\u00a0examining the penis by palpation; documenting any deformities; performing a dynamic Doppler ultrasound; and administering\u00a0questionnaires to assess pain, erectile dysfunction (ED), and the patient\u2019s psychological status. The aim of this study was\u00a0to assess the symptoms of PD and their prevalence among patients in the active phase who were seen at our andrology\u00a0clinic.Methods: The inclusion criteria were: data must be available for\u00a0patients diagnosed with active PD, including a comprehensive medical history, blood test results, penile examination information, photographic evidence of the deformity, color Doppler\u00a0penile ultrasound, and completed questionnaires, including visual analog scale (VAS) for pain assessment, International Index of Erectile Function (IIEF) for assessing erectile function,\u00a0and psychometric test. Exclusion criteria: Patients with PD who are in a stable phase or not having data requested for inclusion.\u00a0Results: We detected penile curvature in 90.5%, penile pain in\u00a054%; ED in 39.3%, significative anxiety in 89.0%, significative depression in 57.6%, and bother in 93.6%.Conclusions: Our study revealed that a large number of\u00a0patients with PD experience significant levels of anxiety and depression, with 38.3% of them experiencing severe anxiety.\u00a0Psychotherapy should be included as part of the treatment plan for patients with PD to enhance their quality of life and\u00a0adherence to treatment.<\/jats:p>","DOI":"10.4081\/aiua.2026.14758","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T13:03:55Z","timestamp":1770123835000},"source":"Crossref","is-referenced-by-count":1,"title":["The psychological impact of Peyronie's disease: a retrospective analysis of 603 patients"],"prefix":"10.4081","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7312-1514","authenticated-orcid":false,"given":"Gianni","family":"Paulis","sequence":"first","affiliation":[{"name":"Department of Urology and Andrology, Peyronie\u2019s Care Center, Castelfidardo Clinical Analysis Center, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Paulis","sequence":"additional","affiliation":[{"name":"School of Cognitive Psychotherapy (SPC), Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"211924","doi-asserted-by":"crossref","unstructured":"1. 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