{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:43:52Z","timestamp":1782740632821,"version":"3.54.5"},"reference-count":35,"publisher":"PAGEPress Publications","issue":"2","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>Introduction: Repeat biopsy remains central to active surveillance (AS) because upgrading and tumor burden may change management.\nMethods: This retrospective paired workflow study included 38 men and 47 repeat biopsy sessions (2023-2025), comprising 846 biopsy cores and 871 H&amp;E slides. Whole-slide imaging (WSI) and conventional microscopy were compared after a washout interval. QuPath was used only for pathologist-guided tumorlength and greatest percentage of cancer (GPC) documentation.\nResults: On the first eligible repeat biopsy, upgrading to ISUP Grade Group (GG) 2 occurred in 7\/38 men (18.4%; 95% CI, 7.7- 34.3). No GG3, cribriform morphology, or intraductal carcinoma was identified. Protocol-linked reclassification occurred in 11\/38 men (28.9%). Slide-level cancer-detection agreement was 856\/871 (98.3%; kappa = 0.91), and raw patient-level agreement for upgrading was 36\/38 (94.7%; kappa = 0.80). After adjudication, no upgraded patient remained missed. QuPathsupported measurement was interpretable in 79\/101 positive core-level assessments (78.2%), with excellent agreement (ICC = 0.98) and shorter median measurement time (41 s vs 78 s).\nConclusions: WSI reproduced management-relevant conventional microscopy outputs in repeat AS biopsies. Its value was organizational and documentary, not autonomous cancer detection or grading.<\/jats:p>","DOI":"10.4081\/aiua.2026.15596","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T07:31:52Z","timestamp":1781508712000},"source":"Crossref","is-referenced-by-count":0,"title":["Digital pathology for repeat prostate biopsy reassessment during active surveillance: an institutional experience"],"prefix":"10.4081","volume":"98","author":[{"given":"Ludovica","family":"Pepe","sequence":"first","affiliation":[{"name":"Anatomic Pathology Unit, Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi\u201d, University of Messina; PhD Program in Translational Molecular Medicine and Surgery, Department of Biomedical Sciences, Dental Sciences and Morpho-functional Imaging, University of Messina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Curduman","sequence":"additional","affiliation":[{"name":"Pathology Unit, Cannizzaro Hospital, Catania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Pepe","sequence":"additional","affiliation":[{"name":"Urology Unit, Cannizzaro Hospital, Catania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Fiorentino","sequence":"additional","affiliation":[{"name":"Anatomic Pathology Unit, Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi\u201d, University of Messina; PhD Program in Translational Molecular Medicine and Surgery, Department of Biomedical Sciences, Dental Sciences and Morpho-functional Imaging, University of Messina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"235781","doi-asserted-by":"crossref","unstructured":"1. 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