{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:59:28Z","timestamp":1790344768935,"version":"4.1.0"},"reference-count":12,"publisher":"PAGEPress Publications","issue":"3","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>Background: Irritative urinary symptoms and postoperative pain are common after prostatic deobstructive surgery for benign prostatic hyperplasia (BPH) and may negatively affect early postoperative recovery and quality of life. Objective: To evaluate the efficacy and safety of a combination of Phycocyanin, PEA and Selenium administered during the first postoperative period in patients undergoing TransUrethral Resection of the Prostate (TURP) and Thulium transurethral VapoResection of the Prostate (ThuVaRP).\nMethods: A preliminary clinical study conducted at the Urology Unit of the Istituto Clinico Citt\u00e0 degli Studi in Milan included 197 patients undergoing prostatic deobstructive surgery for BPH. Patients received the natural complex (2 capsules\/day) for 30 days after surgery. Outcomes were assessed using the International Prostate Symptom Score (IPSS), the related Quality of Life (QoL) index, the Visual Analog Scale (VAS) for pain, and clinical observations.\nResults: Within 30 days after surgery, patients treated with a combination of Phycocyanin, PEA and Selenium showed a 40-60% reduction in IPSS score, with marked improvement in dysuria and urgency-related symptoms, and a 2-3 point reduction in QoL score. VAS pain scores decreased progressively over the first five postoperative days. After four weeks, the mean IPSS reduction reached 10 points. Approximately 70% of treated patients reported no clinically significant postoperative complications.\nConclusions: These preliminary findings suggest that a combination of Phycocyanin, PEA and Selenium may be effective in reducing irritative urinary symptoms, postoperative pain, and complications, while improving quality of life following prostatic deobstructive surgery.<\/jats:p>","DOI":"10.4081\/aiua.2026.15916","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:05:36Z","timestamp":1790341536000},"source":"Crossref","is-referenced-by-count":0,"title":["Postoperative administration of a combination of Phycocyanin, PEA and Selenium following prostatic deobstructive surgery: a preliminary clinical study"],"prefix":"10.4081","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0587-173X","authenticated-orcid":true,"given":"Giuseppe","family":"Saitta","sequence":"first","affiliation":[{"name":"Urology Unit, Istituto Clinico Citt\u00e0 degli Studi, Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Striano","sequence":"additional","affiliation":[{"name":"Humanitas University, Pieve Emanuele, Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Di Salvatore","sequence":"additional","affiliation":[{"name":"Humanitas University, Pieve Emanuele, Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Fontana","sequence":"additional","affiliation":[{"name":"Humanitas University, Pieve Emanuele, Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Di Paola","sequence":"additional","affiliation":[{"name":"Urology Unit, Istituto Clinico Citt\u00e0 degli Studi, Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Simone","family":"Ceresoli","sequence":"additional","affiliation":[{"name":"Urology Unit, Istituto Clinico Citt\u00e0 degli Studi, Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco Anacleto","family":"Mantovani","sequence":"additional","affiliation":[{"name":"Urology Unit, Istituto Clinico Citt\u00e0 degli Studi, Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attilio Luigi","family":"Meazza","sequence":"additional","affiliation":[{"name":"Urology Unit, Istituto Clinico Citt\u00e0 degli Studi, Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Seveso","sequence":"additional","affiliation":[{"name":"Urology Unit, Istituto Clinico Citt\u00e0 degli Studi, Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"253319","doi-asserted-by":"crossref","unstructured":"1. Huang J, Chan CK, Yee S, et al. Global burden and temporal trends of lower urinary tract symptoms: a systematic review and meta-analysis. Prostate Cancer Prostatic Dis 2023.","DOI":"10.1038\/s41391-022-00610-w"},{"key":"253320","doi-asserted-by":"crossref","unstructured":"2. Wei JT, Dauw CA, Brodsky CN. Lower urinary tract symptoms in men: a review. JAMA 2025; 334:809-21.","DOI":"10.1001\/jama.2025.7045"},{"key":"253321","doi-asserted-by":"crossref","unstructured":"3. Porto JG, Bhatia AM, Bhat A, et al. Evaluating transurethral resection of the prostate over twenty years: a systematic review and meta-analysis of randomized clinical trials. World J Urol. 2024.","DOI":"10.1007\/s00345-024-05332-3"},{"key":"253322","doi-asserted-by":"crossref","unstructured":"4. Hu X, Miao J, Xie K, et al. Clinical comparison of TURP, PVP and HoLEP for small volume BPH. Sci Rep 2025. 5. Castellani D, Cormio A, Alberti A, et al. Incidence of overactive","DOI":"10.1038\/s41598-025-18395-y"},{"key":"253323","doi-asserted-by":"crossref","unstructured":"bladder symptoms and dysuria following transurethral interventions for benign prostatic enlargement: a systematic review and metaanalysis. Neurourol Urodyn 2025; 44:1676-88.","DOI":"10.1002\/nau.70129"},{"key":"253324","doi-asserted-by":"crossref","unstructured":"6. Arora B, Khan M, Pridgeon S. Does histological prostatic inflammation during TURP affect postoperative urinary outcomes? Low Urinary Tract Symptoms 2023; 15:57-62.","DOI":"10.1111\/luts.12473"},{"key":"253325","doi-asserted-by":"crossref","unstructured":"7. Saitta G, Mantovani FA, Calabrese B, et al. Prospective observational study on the efficacy and tolerability of a complex of phytochemicals versus dutasteride in the treatment of Lower Urinary Tract Symptomps due to Benign Prostatic Hyperplasia. Arch Ital Urol Androl. 2024; 96:12869.","DOI":"10.4081\/aiua.2024.12869"},{"key":"253326","doi-asserted-by":"crossref","unstructured":"8. Mani V, Korrapati B, Palaniyandi V, et al. Effectiveness of transurethral resection of the prostate in managing lower urinary tract symptoms and enhancing quality of life: a prospective South Indian study. Cureus 2025; 17:e90945.","DOI":"10.7759\/cureus.90945"},{"key":"253327","doi-asserted-by":"crossref","unstructured":"9. Reich O, Gratzke C, Bachmann A, et al. Morbidity, mortality and early outcome of transurethral resection of the prostate: a prospective multicenter evaluation. J Urol 2008; 180:246-9.","DOI":"10.1016\/j.juro.2008.03.058"},{"key":"253328","doi-asserted-by":"crossref","unstructured":"10. Rassweiler J, Teber D, Kuntz R, Hofmann R. Complications of transurethral resection of the prostate (TURP)\u2014incidence, management, and prevention. Eur Urol 2006; 50:969-79.","DOI":"10.1016\/j.eururo.2005.12.042"},{"key":"253329","doi-asserted-by":"crossref","unstructured":"11. Ahyai SA, Gilling P, Kaplan SA, et al. Meta-analysis of functional outcomes and complications following transurethral procedures for lower urinary tract symptoms resulting from benign prostatic enlargement. Eur Urol 2010; 58:384-97.","DOI":"10.1016\/j.eururo.2010.06.005"},{"key":"253330","unstructured":"12. Porru D, Madeddu G, Campus G, et al. Evaluation of morbidity of transurethral prostate resection by symptom score. Urology 2001; 57:1111-5."}],"container-title":["Archivio Italiano di Urologia e Andrologia"],"original-title":[],"link":[{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/download\/15916\/14519","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/download\/15916\/14519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:05:43Z","timestamp":1790341543000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/view\/15916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9,25]]}},"URL":"https:\/\/doi.org\/10.4081\/aiua.2026.15916","relation":{},"ISSN":["2282-4197","1124-3562"],"issn-type":[{"value":"2282-4197","type":"electronic"},{"value":"1124-3562","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,25]]}}}