{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:58:28Z","timestamp":1790589508396,"version":"4.1.0"},"reference-count":28,"publisher":"PAGEPress Publications","issue":"3","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Ital Urol Androl"],"abstract":"<jats:p>Objective(s): Acute urinary retention (AUR) is a common consequence of progressive symptoms in patients with benign prostatic hyperplasia (BPH), with an incidence of approximately 6.8 episodes per 1,000 individuals per year. This study aims to evaluate the effectiveness of \u03b11-adrenergic receptor antagonists in improving the success rate of trial without catheter (TWOC) following episodes of AUR.\nMaterial and method(s): This systematic review and meta-analysis were conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta- Analyses (PRISMA) 2020 statement, and the protocol was registered in PROSPERO (ID: CRD420251127772). A detailed literature search was run in PubMed, Cochrane Library (CENTRAL), and Google Scholar.\nResult(s): The meta-analysis of 8 randomized controlled trials showed that treatment with \u03b11-adrenergic receptor antagonists significantly improved the likelihood of successful trial without catheter (TWOC) as compared with placebo, with a pooled risk difference of 24.5% (95% CI: 18.4-30.7, p &lt; 0.0001).\nConclusions: \u03b11-Adrenergic receptor antagonist therapy significantly improves short-term voiding success following AUR due to BPH and appears to reduce recurrence without a significant increase in adverse events. These findings support the routine use of \u03b11-blockers as part of initial management before TWOC in men with AUR secondary to BPH.<\/jats:p>","DOI":"10.4081\/aiua.2026.15967","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:21:36Z","timestamp":1790587296000},"source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety of \u03b11-adrenergic receptor antagonists in managing acute urinary retention secondary to benign prostatic hyperplasia: a systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.4081","volume":"98","author":[{"given":"Ghaida Sultan","family":"Althunayan","sequence":"first","affiliation":[{"name":"Sulaiman Alrajhi University, Al Qassim"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayan Muossa","family":"Almuossa","sequence":"additional","affiliation":[{"name":"Sulaiman Alrajhi University, Al Qassim"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A.","family":"Almulla","sequence":"additional","affiliation":[{"name":"College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitham","family":"Alshazly","sequence":"additional","affiliation":[{"name":"Urology Department, Tanta University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aymn Mohammad","family":"Al-Hayani","sequence":"additional","affiliation":[{"name":"College of Medicine, King Abdulaziz University, Jeddah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Hetou","sequence":"additional","affiliation":[{"name":"Johns Hopkins Aramco Healthcare, Dhahran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"253901","doi-asserted-by":"crossref","unstructured":"1. Lim KB. Epidemiology of clinical benign prostatic hyperplasia. Asian J Urol. 2017; 4:148-151.","DOI":"10.1016\/j.ajur.2017.06.004"},{"key":"253902","unstructured":"2. Kara \u00d6, Yazici M. Is the double-dose alpha-blocker treatment superior to the single dose in the management of patients suffering from acute urinary retention caused by benign prostatic hyperplasia? Urol J. 2014; 11."},{"key":"253903","doi-asserted-by":"crossref","unstructured":"3. McNeill SA. Spontaneous versus precipitated acute urinary retention: the same? World J Urol. 2006; 24:354-359.","DOI":"10.1007\/s00345-006-0089-8"},{"key":"253904","doi-asserted-by":"crossref","unstructured":"4. Ottaiano N, Shelton T, Sanekommu G, Benson CR. Surgical complications in the management of benign prostatic hyperplasia treatment. Curr Urol Rep. 2022; 23:83-92.","DOI":"10.1007\/s11934-022-01091-z"},{"key":"253905","doi-asserted-by":"crossref","unstructured":"5. McConnell JD, Lieber MM, Nickel JC, et al. The effect of finasteride on the risk of acute urinary retention and the need for surgical treatment among men with benign prostatic hyperplasia. N Engl J Med. 1998; 338:557-563.","DOI":"10.1056\/NEJM199802263380901"},{"key":"253906","doi-asserted-by":"crossref","unstructured":"6. Fitzpatrick JM, Desgrandchamps F, Adjali K, et al. Management of acute urinary retention: a worldwide survey of 6074 men with benign prostatic hyperplasia. BJU Int. 2012; 109:88-95.","DOI":"10.1111\/j.1464-410X.2011.10430.x"},{"key":"253907","doi-asserted-by":"crossref","unstructured":"7. Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021; 372.","DOI":"10.1136\/bmj.n71"},{"key":"253908","unstructured":"8. Centre for Reviews and Dissemination. PROSPERO: International prospective register of systematic reviews. York (UK): University of York. 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A prospective randomized study comparing alfuzosin and tamsulosin in the management of"},{"key":"253914","doi-asserted-by":"crossref","unstructured":"patients suffering from acute urinary retention caused by benign prostatic hyperplasia. Indian J Urol. 2009; 25:474-478.","DOI":"10.4103\/0970-1591.57917"},{"key":"253915","doi-asserted-by":"crossref","unstructured":"14. McNeill SA, Hargreave TB; ALFAUR Study Group. Alfuzosin once daily facilitates return to voiding in patients in acute urinary retention. J Urol. 2004; 171(6 Pt 1):2316-2320.","DOI":"10.1097\/01.ju.0000127743.80759.7a"},{"key":"253916","doi-asserted-by":"crossref","unstructured":"15. Lucas MG, Stephenson TP, Nargund V. Tamsulosin in the management of patients in acute urinary retention from benign prostatic hyperplasia. BJU Int. 2005; 95:354-357.","DOI":"10.1111\/j.1464-410X.2005.05299.x"},{"key":"253917","doi-asserted-by":"crossref","unstructured":"16. Maldonado-\u00c1vila M, Manzanilla-Garc\u00eda HA, Sierra-Ram\u00edrez JA, et al. A comparative study on the use of tamsulosin versus alfuzosin in spontaneous micturition recovery after transurethral catheter removal in patients with benign prostatic growth. Int Urol Nephrol. 2014; 46:687-690.","DOI":"10.1007\/s11255-013-0515-y"},{"key":"253918","doi-asserted-by":"crossref","unstructured":"17. Tiong HY, Tibung MJB, Macalalag M, et al. Alfuzosin 10 mg once daily increases the chances of successful trial without catheter after acute urinary retention secondary to benign prostatic hyperplasia. Urol Int. 2009; 83:44-48.","DOI":"10.1159\/000224867"},{"key":"253919","doi-asserted-by":"crossref","unstructured":"18. Kumar S, Tiwari DP, Ganesamoni R, et al. Prospective randomized placebo-controlled study to assess the safety and efficacy of silodosin in the management of acute urinary retention. Urology. 2013; 82:171-175.","DOI":"10.1016\/j.urology.2013.02.020"},{"key":"253920","unstructured":"19. Qazi SM, Gul W. Trial without catheter with alpha-blockers in acute urinary retention due to benign prostatic hyperplasia. Ann PIMS. 2016; 12:228-232."},{"key":"253921","doi-asserted-by":"crossref","unstructured":"20. Al-Hashimi MMR. Alfuzosin 10 mg once daily in the management of acute urinary retention of benign prostatic hyperplasia: a double-blind, placebo-controlled study. Curr Urol. 2007; 1:28-34.","DOI":"10.1159\/000106525"},{"key":"253922","doi-asserted-by":"crossref","unstructured":"21. Fisher E, Subramonian K, Omar MI. The role of alpha-blockers prior to removal of urethral catheter for acute urinary retention in men. Cochrane Database Syst Rev. 2014; (6).","DOI":"10.1002\/14651858.CD006744.pub3"},{"key":"253923","unstructured":"22. Gwon YN, Park JJ, Yang WJ, et al. Comparing effects of alphablocker management on acute urinary retention secondary to benign"},{"key":"253924","doi-asserted-by":"crossref","unstructured":"prostatic hyperplasia: a systematic review and network meta-analysis. Prostate Int. 2023; 11:91-99.","DOI":"10.1016\/j.prnil.2022.12.002"},{"key":"253925","unstructured":"23. Sandhu JS, Bixler BR, Dahm P, et al. Management of lower urinary tract symptoms attributed to benign prostatic hyperplasia: AUA"},{"key":"253926","doi-asserted-by":"crossref","unstructured":"guideline amendment 2023. J Urol. 2024; 211:11-19.","DOI":"10.1097\/JU.0000000000003698"},{"key":"253927","unstructured":"24. European Association of Urology. EAU Guidelines on Non-neurogenic Male Lower Urinary Tract Symptoms (LUTS), including Benign Prostatic Obstruction (BPO). Arnhem, The Netherlands: EAU Guidelines Office; 2024."},{"key":"253928","doi-asserted-by":"crossref","unstructured":"25. Christensen VS, Skow M, Flottorp SA, et al. Immediate or delayed trial without catheter in acute urinary retention in males: a systematic review. BJUI Compass. 2024; 5:846-861.","DOI":"10.1002\/bco2.369"}],"container-title":["Archivio Italiano di Urologia e Andrologia"],"original-title":[],"link":[{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/download\/15967\/14529","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/download\/15967\/14529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:29:56Z","timestamp":1790587796000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pagepressjournals.org\/aiua\/article\/view\/15967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9,25]]}},"URL":"https:\/\/doi.org\/10.4081\/aiua.2026.15967","relation":{},"ISSN":["2282-4197","1124-3562"],"issn-type":[{"value":"2282-4197","type":"electronic"},{"value":"1124-3562","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,28]]}}}