{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T13:08:47Z","timestamp":1713100127437},"reference-count":0,"publisher":"PAGEPress Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Altern Med Studies"],"abstract":"<jats:p>In the present study the effects of curcumin was studied against the toxic effects induced by 0.025 and 0.050 ml\/ml of cyclophosphamide (CP) in the third instar larvae of transgenic &lt;em&gt;Drosophila melanogaster (hsp70-lacZ)Bg9&lt;\/em&gt; using hsp70 expression and dye exclusion test as a parameter. The exposure of the third instar larvae to 0.025ml\/ml of CP along with 1, 5 and 10 mg\/ml of curcumin results in the dose dependent significant decrease in the &lt;em&gt;hsp70&lt;\/em&gt; expression and tissue damage for 12, 24 and 48hr of duration. Similar results were obtained with the exposure of third instar larvae to 0.050 ml\/ml of CP along with 1, 5 and 10 mg\/ml of curcumin. The selected doses of curcumin i.e. 1, 5 and 10 mg\/ml were not toxic but reduced significantly the expression of &lt;em&gt;hsp70&lt;\/em&gt; and tissue damage induced by CP. The results of the present study suggest that the curcumin has a protective role against the toxic effects of CP in the third instar larvae of transgenic &lt;em&gt;Drosophila melanogaster (hsp70-lacZ)Bg9&lt;\/em&gt;.<\/jats:p>","DOI":"10.4081\/ams.2012.e2","type":"journal-article","created":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T09:50:09Z","timestamp":1326880209000},"page":"2","source":"Crossref","is-referenced-by-count":9,"title":["Protective role of curcumin against the toxic effects of cyclophosphamide in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg9"],"prefix":"10.4081","volume":"2","author":[{"given":"Yasir Hasan","family":"Siddique","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2012,1,4]]},"container-title":["Alternative Medicine Studies"],"original-title":[],"link":[{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/ams\/article\/viewFile\/3131\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T08:46:34Z","timestamp":1463042794000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/ams\/article\/view\/ams.2012.e2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,4]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1,2]]}},"URL":"https:\/\/doi.org\/10.4081\/ams.2012.e2","relation":{},"ISSN":["2038-9485","2038-9477"],"issn-type":[{"value":"2038-9485","type":"electronic"},{"value":"2038-9477","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1,4]]}}}