{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T13:56:53Z","timestamp":1761400613868},"reference-count":6,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2012,3,30]],"date-time":"2012-03-30T00:00:00Z","timestamp":1333065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>A 32-year-old man experienced double vision around January, 2010, followed by weakness of his left upper and lower extremities. Articulation disorders and loss of hearing in his left ear developed, and he was admitted to our hospital on February 14, 2010. Physical examination was normal, and neurological examination showed clear consciousness with no impairment of cognitive function, but with articulation disorders. Olfactory sensation was reduced. Left ptosis and left gaze palsy, complete left facial palsy, perceptive deafness of the left ear, and muscle weakness of the left trapezius muscle were observed. Paresis in the left upper and lower extremities was graded 4\/5 through manual muscle testing. Sensory system evaluation revealed complete left-side palsy, including the face. Deep tendon reflexes were slightly diminished equally on both sides; no pathologic reflex was seen. No abnormality of the brain parenchyma, cerebral nerves or cervicothoracolumbar region was found on brain magnetic resonance imaging. On electroencephalogram, alpha waves in the main frequency band of 8 to 9 Hz were recorded, indicating normal findings. Brain single photon emission computed tomography (SPECT) scan showed reduced blood flow in the right inner frontal lobe and both occipital lobes. Nerve biopsy (left sural nerve) showed reduction of nerve density by 30%, with demyelination. The patient also showed manifestations of multiple cranial nerve disorder, i.e., of the trigeminal nerve, glossopharyngeal nerve, vagus nerve, and hypoglossal nerve. Whole-body examination was negative. Finally, based on ischemic brain SPECT images, spinal fluid findings and nerve biopsy results, peripheral neuropathy accompanied with multiple cranial nerve palsy was diagnosed.<\/jats:p>","DOI":"10.4081\/cp.2012.e40","type":"journal-article","created":{"date-parts":[[2012,3,30]],"date-time":"2012-03-30T15:29:52Z","timestamp":1333121392000},"page":"e40","source":"Crossref","is-referenced-by-count":3,"title":["Hemiplegic Peripheral Neuropathy Accompanied with Multiple Cranial Nerve Palsy"],"prefix":"10.3390","volume":"2","author":[{"given":"Hirohisa","family":"Okuma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeharu","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,3,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1085-9489.2005.10302.x","article-title":"European Federation of Neurological Societies\/Peripheral Nerve Society guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy:report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society","volume":"10","year":"2005","journal-title":"J Peripher Nerv Syst"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1159\/000103645","article-title":"A comparison of clinically atypical with typical chronic inflammatory demyelinating polyradiculoneuropathy","volume":"58","author":"Misra","year":"2007","journal-title":"Eur Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1001\/archneur.62.11.1714","article-title":"Multiple cranial nerve palsies: analysis of 979 cases","volume":"62","author":"Keane","year":"2005","journal-title":"Arch Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jocn.2006.11.001","article-title":"Chronic inflammatory demyelinating polyneuropathy: a 6-year retrospective clinical study of a hospital-based population","volume":"14","author":"Rentzos","year":"2007","journal-title":"J Clin Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/ncpneuro0504","article-title":"Diabetic neuropathy \u2013 a review","volume":"3","author":"Said","year":"2007","journal-title":"Nat Clin Pract Neurol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1136\/jnnp.2006.108290","article-title":"Relapsing demyelinating disease affecting both the central and peripheral nervous systems","volume":"79","author":"Zephir","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["Clinics and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.clinicsandpractice.org\/index.php\/cp\/article\/viewFile\/447\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mdpi.com\/2039-7283\/2\/2\/e40\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T06:11:05Z","timestamp":1644473465000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-7283\/2\/2\/e40"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,30]]},"references-count":6,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,5]]}},"alternative-id":["cp.2012.e40"],"URL":"https:\/\/doi.org\/10.4081\/cp.2012.e40","relation":{},"ISSN":["2039-7283"],"issn-type":[{"value":"2039-7283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,30]]}}}