{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T15:02:27Z","timestamp":1745766147136},"reference-count":11,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T00:00:00Z","timestamp":1346630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>We present the case of a 7-year old boy with traumatic brain injury who received propofol during 38 h. Thirty-six hours after cessation of propofol infusion asystole occurred. After immediate mechanical and medical resuscitation, unreactive dilated pupils were observed. The following computed tomography scan revealed a generalized brain edema with transtentorial herniation. Prolonged bradyarrhythmia, rhabdomyolysis, and peracute renal failure were observed. Despite immediate craniectomy, barbiturate treatment, hemofiltration, and recovery of appropriate cardiac function, the patient died four days after discontinuation of propofol. In this case, metabolic acidosis, cardiac failure, rhabdomyolysis, and renal failure are in accordance with the symptoms of propofol infusion syndrome (PRIS), while seizure, brain edema, and transtentorial herniation could be caused by traumatic brain injury. However, it may be assumed that the entire clinical picture was caused by PRIS. This view could be explained by a common loss of function of ryanodine receptors in patients presenting with PRIS.<\/jats:p>","DOI":"10.4081\/cp.2012.e79","type":"journal-article","created":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T12:34:30Z","timestamp":1346675670000},"page":"e79","source":"Crossref","is-referenced-by-count":3,"title":["Rare, Potentially Fatal, Poorly Understood Propofol Infusion Syndrome"],"prefix":"10.3390","volume":"2","author":[{"given":"Eva","family":"Annen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Girard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Urwyler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,9,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1136\/bmj.305.6854.613","article-title":"Metabolic acidosis and fatal myocardial failure after propofol infusion in children: five case reports","volume":"102","author":"Parke","year":"1992","journal-title":"BMJ"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1097\/01.aco.0000236140.08228.f1","article-title":"Propofol infusion syndrome in anaesthesia and intensive care medicine","volume":"19","author":"Fudickar","year":"2006","journal-title":"Curr Opin Anaesthesiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1007\/s00134-003-1905-x","article-title":"The pathophysiology of propofol infusion syndrome: A simple name for a complex syndrome","volume":"29","author":"Vasile","year":"2003","journal-title":"Intensive Care Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1046\/j.1460-9592.1998.00282.x","article-title":"Propfol infusion syndrome in children","volume":"8","author":"Bray","year":"1998","journal-title":"Paed Anaesth"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"R169","DOI":"10.1186\/cc8145","article-title":"Incidence of propofol-related infusion syndrome in critically ill adults: a prospective, multicenter study","volume":"13","author":"Roberts","year":"2009","journal-title":"Crit Care"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1097\/01.anes.0000265421.40477.a3","article-title":"Incidence of propofol infusion syndrome during non-invasive radiofrequency ablation for atrial flutter or fibrillation","volume":"102","author":"Cravens","year":"2007","journal-title":"Anaesthesiology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/humu.20878","article-title":"Increasing the number of diagnostic mutations in malignant hyperthermia","volume":"30","author":"Levano","year":"2009","journal-title":"Hum Mutat"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0140-6736(00)04064-2","article-title":"Impaired fatty acid oxidation in propofol infusion syndrome","volume":"357","author":"Wolf","year":"2001","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1097\/00003246-199812000-00046","article-title":"Lactic acidemia and bradyarrhythmia in a child sedated with propofol","volume":"26","author":"Cray","year":"1998","journal-title":"Crit Care Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(00)03547-9","article-title":"Long-term propofol infusion and cardiac failure in adult head injured patients","volume":"357","author":"Cremer","year":"2001","journal-title":"Lancet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1152\/physrev.1996.76.2.537","article-title":"Malignant hyperthermia: excitation-contraction coupling, Ca2+ release channel and Ca2+ regulation defects","volume":"76","author":"Mickelson","year":"1996","journal-title":"Physiol Rev"}],"container-title":["Clinics and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-7283\/2\/3\/e79\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T06:17:23Z","timestamp":1644473843000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-7283\/2\/3\/e79"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,3]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,10]]}},"alternative-id":["cp.2012.e79"],"URL":"https:\/\/doi.org\/10.4081\/cp.2012.e79","relation":{},"ISSN":["2039-7283"],"issn-type":[{"value":"2039-7283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,3]]}}}