{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T02:00:58Z","timestamp":1648519258114},"reference-count":20,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2012,11,13]],"date-time":"2012-11-13T00:00:00Z","timestamp":1352764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>A 42-year-old male presented with polyuria, polydipsia and weight loss. His initial physical exam showed a paucity of cushingoid features. Diagnostic work up was consistent with an ectopic adrenocorticotropic hormone (ACTH) secretion. Imaging studies showed a small anterior mediastinal lesion without additional metabolically active tumors. Fine needle aspiration was consistent with a thymic neuroendocrine tumor. Following radical thymectomy, plasma ACTH and cortisol levels remained elevated. Despite medical management, he died within 2 months of presentation of disseminated intracranial aspergillosis. This case underscores the diagnostic dilemma of occult ectopic ACTH-secreting tumors and the fatal consequence of opportunistic infections.<\/jats:p>","DOI":"10.4081\/cp.2012.e82","type":"journal-article","created":{"date-parts":[[2012,11,13]],"date-time":"2012-11-13T15:17:55Z","timestamp":1352819875000},"page":"e82","source":"Crossref","is-referenced-by-count":2,"title":["Occult Ectopic Adrenocorticotropic Hormone Secretion: Diagnostic Dilemma and Infective Consequence"],"prefix":"10.3390","volume":"2","author":[{"given":"Njideka","family":"Momah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Koroscil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,11,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0022-5223(96)70409-9","article-title":"Thymic neuroendocrine carcinoma (carcinoid): a clinicopathologic study of fourteen cases","volume":"111","author":"de Montpr\u00e9ville","year":"1996","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"588","DOI":"10.4158\/EP.14.5.588","article-title":"A case of occult ectopic adrenocorticotropic hormonesecreting tumor: diagnostic and management dilemmas","volume":"5","author":"Cannon","year":"2008","journal-title":"Endocr Pract"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1016\/S0140-6736(03)14904-5","article-title":"Glucocorticoids and invasive fungal infections","volume":"362","author":"Lionakis","year":"2003","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1067\/mtc.2003.133","article-title":"Aggressive multimodality treatment of invasive thymic carcinoma","volume":"125","author":"Greene","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref5","first-page":"433","article-title":"Thymic tumors associated with Cushing's syndrome: review of three cases","volume":"2","author":"Scholz","year":"1959","journal-title":"Proc Staff Meet Mayo Clin"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/1097-0142(197204)29:4<1061::AID-CNCR2820290456>3.0.CO;2-3","article-title":"Mediastinal endocrine neoplasm, of probable thymic origin, related to carcinoid tumor. 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