{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T19:43:26Z","timestamp":1775591006225,"version":"3.50.1"},"reference-count":9,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T00:00:00Z","timestamp":1459382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Gallbladder granulomas are exceedingly rare, reported in association with tuberculosis or sarcoidosis. Here we report a case of gallbladder granulomatous cholecystitis occurring in the context of sarcoidosis. A 70-years old man presented with abdominal pain, nausea and vomiting. The medical history revealed sarcoidosis diagnosed more than 20-years previously. 2-years previously the patient showed renal lithiasis, hypercalcemia and, increased angiotensin converting enzyme. The imaging features suggested thoraco-abdominal sarcoidosis. Prednisone was given at 1.2 mg\/kg\/day initially, than decreased, being at 2.5 mg\/day at present. The ultrasound examination showed gallbladder lithiasis. A cholecystectomy was performed. Microscopy showed subacute and chronic cholecystitis with several epithelioid and giant cell granulomas some of them perineural. In conclusion, we report a case of granulomatous cholecystitis occurring in the course of treated sarcoidosis. The perineural location of granulomas may give further insights into the pathogenesis of gallbladder dysmotility.<\/jats:p>","DOI":"10.4081\/cp.2016.811","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T14:29:12Z","timestamp":1459434552000},"page":"811","source":"Crossref","is-referenced-by-count":7,"title":["Granulomatous Lithiasic Cholecystitis in Sarcoidosis"],"prefix":"10.3390","volume":"6","author":[{"given":"Adriana","family":"Handra-Luca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,3,31]]},"reference":[{"key":"ref1","series-title":"Rosai and Ackerman\u2019s surgical pathology. Expert consult","author":"Rosai","year":"2011"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"754","DOI":"10.4081\/cp.2015.754","article-title":"Rare presentation of gall bladder tuberculosis in a non immuno-compromised patient","volume":"5","author":"Kumar","year":"2015","journal-title":"Clin Pract"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0016-5085(19)34541-X","article-title":"Sarcoidosis of the gall bladder","volume":"49","author":"Lloyd-Davies","year":"1965","journal-title":"Gastroenterology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1097\/00004836-200408000-00016","article-title":"Gall bladder involvement in sarcoidosis","volume":"38","author":"Mert","year":"2004","journal-title":"J Clin Gastroenterol"},{"key":"ref5","first-page":"664","article-title":"[Obstructive jaundice caused by granulomatous stenosis of the extrahepatic bile ducts in sarcoidosis]","volume":"12","author":"Kusielewicz","year":"1988","journal-title":"Gastroenterol Clin Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1001\/archinte.1983.00350110178037","article-title":"Acute cholecystitis as a complication of sarcoidosis","volume":"143","author":"Freed","year":"1983","journal-title":"Arch Intern Med"},{"key":"ref7","first-page":"702868","article-title":"Sarcoidosis incidentally diagnosed: a case report","volume":"2014","author":"Kesici","year":"2014","journal-title":"Case Rep Pulmonol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/cup.12484","article-title":"Perineural granulomas in cutaneous sarcoidosis may be associated with sarcoidosis small-fiber neuropathy","volume":"42","author":"Munday","year":"2015","journal-title":"J Cutan Pathol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0016-5085(76)80444-1","article-title":"The influence of hypercalcemia on basal and cholecystokinin-stimulated pancreatic, gallbladder, and gastric functions in man","volume":"71","author":"Malagelada","year":"1976","journal-title":"Gastroenterology"}],"container-title":["Clinics and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.clinicsandpractice.org\/index.php\/cp\/article\/viewFile\/811\/690","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mdpi.com\/2039-7283\/6\/1\/811\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T06:35:14Z","timestamp":1644474914000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-7283\/6\/1\/811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,31]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,3]]}},"alternative-id":["cp.2016.811"],"URL":"https:\/\/doi.org\/10.4081\/cp.2016.811","relation":{},"ISSN":["2039-7283"],"issn-type":[{"value":"2039-7283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,31]]}}}