{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:36:16Z","timestamp":1763642176708},"reference-count":18,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T00:00:00Z","timestamp":1486598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Two cases of calcifying cystic odontogenic tumor (CCOT) of the dental follicle in an impacted third molar without clinical and radiological evidence are reported during routine histopathological examination. In both the cases left mandibular third molar was mesioangularly impacted with pericoronal radiolucency of less than 2.5 mm, which was not indicative of any pathology. As a routine protocol (which is not practiced widely) of our institution, dental follicles associated with extracted molars were sent for histopathological examination. Histopathological features were consistent with CCOT with pathognomonic ghost cell transformation of odontogenic epithelium. The patients were followed for one year with no recurrence. This paper emphasizes the importance of routine histopathological examination of dental follicles associated with asymptomatic impacted teeth without any clinical or radiographic evidence of follicular lesion.<\/jats:p>","DOI":"10.4081\/cp.2017.933","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T15:56:10Z","timestamp":1486655770000},"page":"933","source":"Crossref","is-referenced-by-count":7,"title":["Calcifying Cystic Odontogenic Tumor in Radiologically Normal Dental Follicular Space of Mandibular Third Molars: Report of Two Cases"],"prefix":"10.3390","volume":"7","author":[{"given":"Gargi S.","family":"Sarode","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin C.","family":"Sarode","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghevaram","family":"Prajapati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahesh","family":"Maralingannavar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shankargouda","family":"Patil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,2,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S1079-2104(00)70119-3","article-title":"Early soft tissue pathosis associated with third molars without pericoronal radiolucency","volume":"89","author":"Adelsperger","year":"2000","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref2","first-page":"259","article-title":"Incidence of cystic changes in radiographically normal impacted mandibular third molar follicles","volume":"37","author":"Baykul","year":"1999","journal-title":"Br J Oral Maxillofac Surg"},{"key":"ref3","first-page":"158","article-title":"Prevalence of impacted teeth and associated pathologies: a radiographic study of Chinese population","volume":"9","author":"Chu","year":"2003","journal-title":"Hong Kong Med J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/S0278-2391(10)80417-3","article-title":"Dental follicular tissue: misinterpretation as odontogenic tumors","volume":"51","author":"Kim","year":"1993","journal-title":"J Oral Maxillofac Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0901-5027(89)80055-4","article-title":"Pathologic changes related to long term impactions of third molars: a radiographic study","volume":"18","author":"Eliason","year":"1989","journal-title":"Int J Oral Maxillofac Surg"},{"key":"ref6","first-page":"187","article-title":"Can the follicle-crown ratio of the impacted third molars be a reliable indicator of pathologic problem?","volume":"15","author":"Haghanifar","year":"2014","journal-title":"J Dent (Shiraz)"},{"key":"ref7","first-page":"31","article-title":"Analysis of the immunoexpression of Ki-67 and Bcl-2 in the pericoronal tissues of impacted teeth, dentigerous cysts and gingiva using software image analysis","volume":"10","author":"Rahman","year":"2013","journal-title":"Dent Res J (Isfahan)"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1054\/bjom.1999.0061","article-title":"Pathologic change in soft tissue associated with radiographically \u201cnormal\u201d third molar impactions","volume":"37","author":"Glosser","year":"1999","journal-title":"Br J Oral Maxillofac Surg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jcms.2006.11.005","article-title":"Low grade malignant fibrosarcoma of the dental follicle of an unerupted third molar without clinical evidence of any follicular lesion","volume":"35","author":"Leitner","year":"2007","journal-title":"J Craniomaxillofac Surg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"208","DOI":"10.4103\/0970-9290.42952","article-title":"Pathosis associated with radiographically normal follicular tissues in third molar impactions: a clinicopathological study","volume":"19","author":"Mesgarzadeh","year":"2008","journal-title":"Indian J Dent Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0011-8532(22)00227-0","article-title":"Periocoronal radiolucencies with and without radiopacities","volume":"38","author":"Miller","year":"1994","journal-title":"Dent Clin North Am"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3109\/00016358109162284","article-title":"Calcifying odontogenic cyst. Range, variations and neoplastic potential","volume":"39","author":"Praetorius","year":"1981","journal-title":"Acta Odontol Scand"},{"key":"ref13","first-page":"633","article-title":"Pathologic changes in the pericoronal soft tissue of unerupted third molars","volume":"32","author":"Rakprasitkul","year":"2001","journal-title":"Quintessence Int"},{"key":"ref14","first-page":"ZC106","article-title":"Histopathological and radiographic analysis of dental follicle of impacted teeth using modified Gallego\u2019s stain","volume":"10","author":"Satheesan","year":"2016","journal-title":"J Clin Diagn Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"385","DOI":"10.4103\/0970-9290.70809","article-title":"Histopathologic changes in soft tissue associated with radiographically normal impacted third molars","volume":"21","author":"Kotrashetti","year":"2010","journal-title":"Indian J Dent Res"},{"key":"ref16","doi-asserted-by":"crossref","DOI":"10.7727\/wimj.2015.069","article-title":"Histopathologic finding of soft tissue associated with impacted mandibular third molars that did not exhibit pathologic pericoronal radiolucency","author":"Tak","year":"2015","journal-title":"West Indian Med J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s40496-016-0087-x","article-title":"Benign odontogenic tumors: origins, immunophenotypic features, and genetic alterations","volume":"3","author":"Jiang","year":"2016","journal-title":"Curr Oral Health Rep"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.bjoms.2008.02.008","article-title":"Cystic changes in dental follicle associated with radiographically normal impacted mandibular third molar","volume":"46","author":"Saravana","year":"2008","journal-title":"Br J Oral Maxillofac Surg"}],"container-title":["Clinics and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.clinicsandpractice.org\/index.php\/cp\/article\/viewFile\/933\/783","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mdpi.com\/2039-7283\/7\/1\/933\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T22:22:21Z","timestamp":1658614941000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-7283\/7\/1\/933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,9]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1]]}},"alternative-id":["cp.2017.933"],"URL":"https:\/\/doi.org\/10.4081\/cp.2017.933","relation":{},"ISSN":["2039-7283"],"issn-type":[{"value":"2039-7283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,9]]}}}