{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:02:05Z","timestamp":1757703725100},"reference-count":17,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T00:00:00Z","timestamp":1526428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Amyloidosis is a complex group of disorders that can involve many organs and cause their dysfunction. Cardiac involvement indicates worse prognosis and influences treatment strategies. Cardiac amyloidosis is an under-diagnosed entity and high index of clinical suspicion and careful interpretation of basic diagnostic tools such as electrocardiogram and echocardiography is needed for early detection. Congestive heart failure due to restrictive pattern and\/or conduction system abnormality, in absence of coronary artery disease should raise suspicion. We present a case of transthyretin related cardiac amyloidosis and discuss the key clinical and diagnostic findings along with review of existing literature regarding its management and outcomes.<\/jats:p>","DOI":"10.4081\/cp.2018.1054","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T15:05:11Z","timestamp":1526483111000},"page":"1054","source":"Crossref","is-referenced-by-count":2,"title":["Revisiting Transthyretin Related Cardiac Amyloidosis: Case Report and Review of Literature"],"prefix":"10.3390","volume":"8","author":[{"given":"Munish","family":"Sharma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Koman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary S.","family":"Ledley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Hae","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,5,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.med.57.121304.131243","article-title":"Amyloidosis","volume":"57","author":"Pepys","year":"2006","journal-title":"Annu Rev Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1161\/CIRCULATIONAHA.111.069195","article-title":"Cardiac amyloidosis","volume":"126","author":"Quarta","year":"2012","journal-title":"Circulation"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0002-9149(84)90543-5","article-title":"Cardiac amyloidosis simulating hypertrophic cardiomyopathy","volume":"53","author":"Sedlis","year":"1984","journal-title":"Am J Cardiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/S0002-9149(97)00653-X","article-title":"Features and prognosis of exertional syncope in light-chain associated AL cardiac amyloidosis","volume":"80","author":"Chamarthi","year":"1997","journal-title":"Am J Cardiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/S0002-9149(97)82785-3","article-title":"Symptomatic conduction system disease in cardiac amyloidosis","volume":"80","author":"Mathew","year":"1997","journal-title":"Am J Cardiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0735-1097(97)00267-2","article-title":"Electrophysiologic abnormalities in AL (primary) amyloidosis with cardiac involvement","volume":"30","author":"Reisinger","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1212\/01.wnl.0000276951.39112.2b","article-title":"Primary systemic amyloidosis with ischemic stroke as a presenting complication","volume":"69","author":"Zubkov","year":"2007","journal-title":"Neurology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1001\/archinte.1988.00380030168027","article-title":"Endomyocardial biopsy in 30 patients with primary amyloidosis and suspected cardiac involvement","volume":"148","author":"Pellikka","year":"1988","journal-title":"Arch Intern Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1182\/blood-2009-07-230722","article-title":"Classification of amyloidosis by laser microdissection and mass spectrometry- based proteomic analysis in clinical biopsy specimens","volume":"114","author":"Vrana","year":"2009","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1161\/CIRCULATIONAHA.116.021612","article-title":"Nonbiopsy diagnosis of cardiac transthyretin amyloidosis","volume":"133","author":"Gillmore","year":"2016","journal-title":"Circulation"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.amjcard.2004.10.028","article-title":"Electrocardiographic findings in primary systemic amyloidosis and biopsyproven cardiac involvement","volume":"95","author":"Murtagh","year":"2005","journal-title":"Am J Cardiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jacc.2003.08.043","article-title":"Noninvasive diagnosis of biopsyproven cardiac amyloidosis","volume":"43","author":"Rahman","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"ref13","first-page":"227","article-title":"Cardiomyopathies, hypertensive and pulmonary heart disease. Textbook of Clinical Echocardiography. Third ed","author":"Otto","year":"2004"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1161\/01.CIR.0000068313.67758.4F","article-title":"Longitudinal myocardial function assessed by tissue velocity, strain, and strain rate tissue Doppler echocardiography in patients with AL (primary) cardiac amyloidosis","volume":"107","author":"Koyama","year":"2003","journal-title":"Circulation"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1200\/JCO.2011.38.5724","article-title":"Revised prognostic staging system for light chain amyloidosis incorporating cardiac biomarkers and serum free light chain measurements","volume":"30","author":"Kumar","year":"2012","journal-title":"J Clin Oncol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1161\/CIRCULATIONAHA.108.785014","article-title":"Intracardiac thrombosis and anticoagulation therapy in cardiac amyloidosis","volume":"119","author":"Feng","year":"2009","journal-title":"Circulation"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/00007890-199707150-00014","article-title":"Progression of ventricular wall thickening after liver transplantation for familial amyloidosis","volume":"64","author":"Dubrey","year":"1997","journal-title":"Transplantation"}],"container-title":["Clinics and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.clinicsandpractice.org\/index.php\/cp\/article\/download\/1054\/908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.clinicsandpractice.org\/index.php\/cp\/article\/download\/1054\/914","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mdpi.com\/2039-7283\/8\/2\/1054\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T06:52:36Z","timestamp":1644475956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-7283\/8\/2\/1054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,16]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,3]]}},"alternative-id":["cp.2018.1054"],"URL":"https:\/\/doi.org\/10.4081\/cp.2018.1054","relation":{},"ISSN":["2039-7283"],"issn-type":[{"value":"2039-7283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,16]]}}}