{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:47:45Z","timestamp":1762876065395},"reference-count":10,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>In recent years, influenza infection in the pediatric population has been a widescale issue that physicians face during the winter season. Medications used to treat and prevent such infections include Oseltamivir, an anti-viral neuraminidase inhibitor developed for both influenzas A and B. The most commonly well-known and manifesting adverse effects are nausea, vomiting and gastrointestinal upset. There is paucity of reports on other potential serious side effects of Oseltamivir in the pediatric population. One of the rarely reported adverse reactions in adult population is sinus bradycardia. This case reports the development of sinus bradycardia in a pediatric patient after administration of Oseltamivir. The previously healthy five-year-old patient was started on Oseltamivir after a positive polymerase chain reaction for influenza. The patient developed sinus bradycardia but remained hemodynamically stable. This finding led to consultations and investigations to determine the cause of bradycardia. It is pivotal to increase the awareness of the potential link between Oseltamivir and bradycardia in pediatric and adult populations to avoid unnecessary clinical investigations and to enhance physician decisionmaking. A prospective cohort study on Oseltamivir is needed for better understanding of its adverse effects in the pediatric population.<\/jats:p>","DOI":"10.4081\/cp.2018.1094","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T18:35:48Z","timestamp":1543430148000},"page":"1094","source":"Crossref","is-referenced-by-count":10,"title":["Suspected Oseltamivir-Induced Bradycardia in a Pediatric Patient: A Case Report from King Abdullah Specialist Children\u2019s Hospital, Riyadh, Saudi Arabia"],"prefix":"10.3390","volume":"8","author":[{"given":"Hisham","family":"Arabi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Abou Zaid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Alreefi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salman","family":"Alahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"ref1","year":"2018"},{"key":"ref2","article-title":"Estimated influenza illnesses, medical visits, hospitalizations, and deaths in the United States \u2013 2017-2018 influenza season. Seasonal influenza (Flu)","year":"2018"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e20172550","DOI":"10.1542\/peds.2017-2550","article-title":"Recommendations for prevention and control of influenza in children, 2017-2018","volume":"140","year":"2017","journal-title":"Pediatrics"},{"key":"ref4","year":"2016","journal-title":"South San Francisco: Genentech USA, Inc."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00006454-200102000-00002","article-title":"Oral oseltamivir treatment of influenza in children","volume":"20","author":"Whitley","year":"2001","journal-title":"Pediatr Infect Dis J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4103\/0976-500X.81901","article-title":"Adverse drug reaction profile of oseltamivir in children","volume":"2","author":"Dalvi","year":"2011","journal-title":"J Pharmacol Pharmacother"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e374","DOI":"10.1016\/j.ijid.2010.03.009","article-title":"Suspected oseltamivir-induced bradycardia","volume":"14","author":"Karplus","year":"2010","journal-title":"Int J Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/jp.2010.159","article-title":"Oseltamivir treatment and prophylaxis in a neonatal intensive care unit during a 2009 H1N1 influenza outbreak","volume":"31","author":"Pannaraj","year":"2011","journal-title":"J Perinatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/23744235.2016.1189592","article-title":"The mechanisms of delayed onset type adverse reactions to oseltamivir","volume":"48","author":"Hama","year":"2016","journal-title":"Infect Dis (Lond)"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S0140-6736(10)62226-X","article-title":"Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: a systematic review of observational studies","volume":"377","author":"Fleming","year":"2011","journal-title":"Lancet"}],"container-title":["Clinics and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.clinicsandpractice.org\/index.php\/cp\/article\/download\/1094\/936","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.clinicsandpractice.org\/index.php\/cp\/article\/download\/1094\/944","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mdpi.com\/2039-7283\/8\/4\/1094\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T06:54:37Z","timestamp":1644476077000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-7283\/8\/4\/1094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,28]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,10]]}},"alternative-id":["cp.2018.1094"],"URL":"https:\/\/doi.org\/10.4081\/cp.2018.1094","relation":{},"ISSN":["2039-7283"],"issn-type":[{"value":"2039-7283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,28]]}}}