{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:18:55Z","timestamp":1777508335460,"version":"3.51.4"},"reference-count":20,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T00:00:00Z","timestamp":1568592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics and Practice"],"abstract":"<jats:p>Acute eosinophilic appendicitis (AEA) is a rare variant of appendix inflammation possibly linked to allergy. Histopathological evidence of eosinophilic infiltration of the muscularis propria and edema separating the muscle fibers is the gold standard for the diagnosis. Here, we report a case of a young boy with AEA following a skin reaction of possible allergic origin. A 6-year-old male was presented to the emergency department with a two-day diffuse abdominal pain and tenderness in the right lower quadrant. A possible allergic reaction had occurred five days before as a pruritic rash. There was no history of allergy and the stool examination was negative for parasites. The initial diagnosis was acute appendicitis, and appendectomy was performed. The histopathological diagnosis was AEA. Further studies on the proper diagnostic and treatment approach of AEA before surgery are required.<\/jats:p>","DOI":"10.4081\/cp.2019.1177","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T21:24:28Z","timestamp":1568669068000},"page":"1177","source":"Crossref","is-referenced-by-count":2,"title":["Acute Eosinophilic Appendicitis after Generalized Skin Reaction Due to Unknown Cause in a Child: Case Report and Literature Review"],"prefix":"10.3390","volume":"9","author":[{"given":"Maria","family":"Aggelidou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Kambouri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Kouroupi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Cassimos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soultana","family":"Foutzitzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Savas","family":"Deftereos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/S0140-6736(15)00275-5","article-title":"Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management","volume":"386","author":"Bhangu","year":"2015","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S1092-9134(00)90011-X","article-title":"The pathology of acute appendicitis","volume":"4","author":"Carr","year":"2000","journal-title":"Ann Diagn Pathol"},{"key":"ref3","first-page":"491","article-title":"Eosinophils in acute appendicitis: possible significance","volume":"40","author":"Aravindan","year":"1997","journal-title":"Indian J Pathol Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"258","DOI":"10.4103\/0377-4929.64343","article-title":"Acute eosinophilic appendicitis and the significance of eosinophil-Edema lesion","volume":"53","author":"Aravindan","year":"2010","journal-title":"Indian J Pathol Microbiol"},{"key":"ref5","first-page":"208","article-title":"Eosinophilic appendicitis: Case report of five cases & review of literature","volume":"2","author":"Jain","year":"2013","journal-title":"J Med Res Pract"},{"key":"ref6","first-page":"103","article-title":"Eosinophilic acute appendicitis and intra-abdominal granuloma caused by Enterobius vermicularis in a pediatric patient","volume":"1","author":"Garza-Serna","year":"2016","journal-title":"Surg Infect Case Rep"},{"key":"ref7","first-page":"87","article-title":"Acute eosinophilic appendicitis: A prospective study in consecutive 400 appendectomy cases","volume":"16","author":"Kumar","year":"2017","journal-title":"J Dent Med Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"bcr0120125670","DOI":"10.1136\/bcr.01.2012.5670","article-title":"Eosinophilic acute appendicitis caused by Strongyloides stercoralis and Enterobius vermicularis in an HIV-positive patient","volume":"2012","author":"Cruz","year":"2012","journal-title":"BMJ Case Rep"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1093\/jpids\/pis090","article-title":"Eosinophilic appendicitis attributable to Strongyloides infection in a pediatric renal transplant patient","volume":"2","author":"Rha","year":"2013","journal-title":"J Pediatric Infect Dis Soc"},{"key":"ref10","first-page":"107","article-title":"Acute eosinophilic appendicitis: an unusual variant of appendix inflammation","volume":"23","author":"Egeli","year":"2013","journal-title":"Kolon Rektum Hast Derg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"150","DOI":"10.5455\/jihp.20140512102819","article-title":"The significance of mast cells and eosinophils counts in surgically resected appendix","volume":"2","author":"Kolur","year":"2014","journal-title":"J Interdiscipl Histopathol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s11605-008-0511-1","article-title":"Atopy is a risk factor for acute appendicitis? A prospective clinical study","volume":"12","author":"Harlak","year":"2008","journal-title":"J Gastrointest Surg"},{"key":"ref13","first-page":"25","article-title":"Barium-induced allergic appendicitis: A case report","volume":"3","author":"Manuel","year":"2017","journal-title":"J Case Rep Image Surg"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3126\/jpn.v2i3.6025","article-title":"Histopathologic analysis of appendectomy specimens","volume":"2","author":"Shrestha","year":"2012","journal-title":"J Pathol Nepal"},{"key":"ref15","first-page":"18","article-title":"Acute eosinophilic appendicitis: case report of three cases with brief review of literature","volume":"2","author":"Rajeshwari","year":"2015","journal-title":"Ann Appl Bio-Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000369540","article-title":"Eosinophilic enteritis","volume":"33","author":"Pineton","year":"2015","journal-title":"Dig Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000493668","article-title":"Eosinophilic gastrointestinal diseases in childhood","volume":"73","author":"Papadopoulou","year":"2018","journal-title":"Ann Nutr Metab"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.clinimag.2018.06.016","article-title":"Acute eosinophilic appendicitis: a radiologic-pathologic correlation","volume":"51","author":"Yaeger","year":"2018","journal-title":"Clin Imaging"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e227178","DOI":"10.1136\/bcr-2018-227178","article-title":"Acute eosinophilic appendicitis simulating uncomplicated appendicitis","volume":"11","author":"Takabatake","year":"2018","journal-title":"BMJ Case Rep"},{"key":"ref20","first-page":"1","article-title":"Primary eosinophilic obliterative appendicitis","volume":"13","author":"Kanthikar","year":"2014","journal-title":"Online J Health All Sci"}],"container-title":["Clinics and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.clinicsandpractice.org\/index.php\/cp\/article\/download\/1177\/994","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.clinicsandpractice.org\/index.php\/cp\/article\/download\/1177\/1005","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mdpi.com\/2039-7283\/9\/3\/1177\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T07:01:20Z","timestamp":1644476480000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-7283\/9\/3\/1177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,16]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,8]]}},"alternative-id":["cp.2019.1177"],"URL":"https:\/\/doi.org\/10.4081\/cp.2019.1177","relation":{},"ISSN":["2039-7283"],"issn-type":[{"value":"2039-7283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,16]]}}}