{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T14:12:56Z","timestamp":1778163176415,"version":"3.51.4"},"reference-count":9,"publisher":"PAGEPress Publications","issue":"1","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>The acronym PHACES stands for posterior fossa malformations, hemangiomas, arterial anomalies (cardiovascular or cerebrovascular), coarctation of the aorta\/cardiac defects, eye abnormalities, and sternal defects. The characteristic dermatological clinical manifestation of PHACES syndrome is a segmental and extensive hemangioma, usually on the face. A combined therapy with 1,064 nm Nd-YAG\/595-nm pulsed dye laser was performed in a young 15-year-old patient with PHACES syndrome, who presented a hemangioma on the left side of the face, located in the periorbital region. A first session with Nd-YAG laser (2,5 mm spot size, fluence 100 J\/cm2, pulse duration 7 ms) for the treatment of teleangectasias and subsequently, three treatment sessions with pulsed dye laser (12 mm spot size, fluence 7 J\/cm2, pulse duration 0,5 ms, repetition rate 0,6 Hz), once every 2 months, were performed. No postoperative complications were recorded, except for transient purpura after the pulsed dye laser sessions. The vascular lesion had a decrease in size bigger than 75%, and these results was maintained 6 months after the last treatment. Combined therapy Nd- YAG\/pulsed dye laser is an effective and noninvasive procedure for hemangiomas in patients with PHACES syndrome.<\/jats:p>","DOI":"10.4081\/dr.2021.8751","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T03:30:57Z","timestamp":1616038257000},"source":"Crossref","is-referenced-by-count":5,"title":["Nd:YAG laser in association with pulsed dye laser for the treatment of PHACES syndrome"],"prefix":"10.4081","volume":"13","author":[{"given":"Francesca","family":"Negosanti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Silvestri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Bennardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Durastante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7948-8536","authenticated-orcid":false,"given":"Ester","family":"Del Duca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Cannarozzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven P.","family":"Nistic\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"5042","doi-asserted-by":"crossref","unstructured":"Haggstrom AN, Lammer EJ, Schneider RA, Marcucio R, Frieden IJ. Patterns of infantile hemangiomas: new clues to hemangioma pathogenesis and embryonic facial development. Pediatrics. 2006;117:698\u2013703","DOI":"10.1542\/peds.2005-1092"},{"key":"5043","doi-asserted-by":"crossref","unstructured":"Chiller KG, Passaro D, Frieden IJ. Hemangiomas of infancy: clinical characteristics, morphologic subtypes, and their relationship to race, ethnicity, and sex. Arch Dermatol. 2002;138:1567\u20131576","DOI":"10.1001\/archderm.138.12.1567"},{"key":"5044","doi-asserted-by":"crossref","unstructured":"Winter PR, Itinteang T, Leadbitter P, Tan ST. PHACE syndrome--clinical features, aetiology and management. Acta Paediatr. 2016 Feb;105(2):145-53.","DOI":"10.1111\/apa.13242"},{"key":"5045","doi-asserted-by":"crossref","unstructured":"Hartmann F, Lockmann A, Gr\u00f6nemeyer LL et al. Nd:YAG and pulsed dye laser therapy in infantile haemangiomas: a retrospective analysis of 271 treated haemangiomas in 149 children. J Eur Acad Dermatol Venereol. 2017 Aug;31(8):1372-1379. doi: 10.1111\/jdv.14074. Epub 2017 Jan 23.","DOI":"10.1111\/jdv.14074"},{"key":"5046","doi-asserted-by":"crossref","unstructured":"Tanzi EL, Lupton JR, Alster TS. Lasers in dermatology: four decades of progress. J Am Acad Dermatol. 2003;49:1\u201331. quiz 31-34.","DOI":"10.1067\/mjd.2003.582"},{"key":"5047","doi-asserted-by":"crossref","unstructured":"Nistic\u00f2 S, Campolmi P, Moretti S, Del Duca E, Bruscino N, Conti R, Bassi A, Cannarozzo G. Nonconventional Use of Flash-Lamp Pulsed-Dye Laser in Dermatology. Biomed Res Int. 2016;2016:7981640.","DOI":"10.1155\/2016\/7981640"},{"key":"5048","doi-asserted-by":"crossref","unstructured":"Cannarozzo G, Negosanti F, Sannino M et al. Q-switched Nd:YAG laser for cosmetic tattoo removal. Dermatol Ther. 2019 Sep;32(5):e13042.","DOI":"10.1111\/dth.13042"},{"key":"5049","unstructured":"Del Duca E, Zingoni T, Bennardo L et al. Long-Term Follow-Up for Q-Switched Nd:YAG Treatment of Nevus of Ota: Are High Number of Treatments Really Required? A Case Report. Photobiomodul Photomed Laser Surg. 2020 Aug 5."},{"key":"5050","doi-asserted-by":"crossref","unstructured":"Zutt M. Laser treatment of vascular dermatological diseases using a pulsed dye laser (595 nm) in combination with a Neodym:YAG-laser (1064 nm). Photochem Photobiol Sci. 2019 Jul 10;18(7):1660-1668.","DOI":"10.1039\/C9PP00079H"}],"container-title":["Dermatology Reports"],"original-title":[],"link":[{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/8751\/8543","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/8751\/8567","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/8751\/8543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:30:42Z","timestamp":1778160642000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/view\/8751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,17]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,3,18]]}},"URL":"https:\/\/doi.org\/10.4081\/dr.2021.8751","relation":{},"ISSN":["2036-7406","2036-7392"],"issn-type":[{"value":"2036-7406","type":"electronic"},{"value":"2036-7392","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,17]]}}}