{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:34:23Z","timestamp":1784158463950,"version":"3.55.0"},"reference-count":13,"publisher":"PAGEPress Publications","issue":"3","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Necrotizing fasciitis (NF) is a devastating soft tissue infection affecting fascias and subcutaneous soft tissues. While it is associated with several risk factors, including malignancy, alcoholism, liver disease, drug use, malnutrition, diabetes, male gender and old age, few case reports in the literature describe its rare connection with genital malignancy. Vulvar squamous cell carcinoma (SCC) is the fourth most common malignancy, representing 5% of all gynaecological tumours among women. NF due to vulvar SCC is a rare complication. In this article, we present the 1991 case of a 58-year-old diabetic female patient with NF due to vulvar SCC. While surgical intervention was successful, the prognosis for vulvar SCC was poor because of late detection.<\/jats:p>","DOI":"10.4081\/dr.2022.9082","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T15:56:03Z","timestamp":1647532563000},"source":"Crossref","is-referenced-by-count":2,"title":["Necrotizing fasciitis arising from squamous cell carcinoma of the vulva"],"prefix":"10.4081","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5746-9326","authenticated-orcid":false,"given":"Dua","family":"Cebeci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eirin","family":"Ya\u015far","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tevfik","family":"Eker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6rgu\u0308n","family":"Bayraktaro\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"6796","doi-asserted-by":"crossref","unstructured":"Peri M, Grassadonia A, Iezzi L, et al. A Case of Stage I Vulvar Squamous Cell Carcinoma with Early Relapse and Rapid Disease Progression. Case Rep Oncol Med 2019;2019:1018492.","DOI":"10.1155\/2019\/1018492"},{"key":"6797","doi-asserted-by":"crossref","unstructured":"Ueda Y, Enomoto T, Kimura T, et al. Two distinct pathways to development of squamous cell carcinoma of the vulva. J Skin Cancer 2011;2011:951250.","DOI":"10.1155\/2011\/951250"},{"key":"6798","doi-asserted-by":"crossref","unstructured":"Woolderink JM, de Bock GH, de Hullu JA, et al. Patterns and frequency of recurrences of squamous cell carcinoma of the vulva. Gynecol Oncol 2006;103:293-9.","DOI":"10.1016\/j.ygyno.2006.03.010"},{"key":"6799","doi-asserted-by":"crossref","unstructured":"Alkatout I, Schubert M, Garbrecht N, et al. Vulvar cancer: epidemiology, clinical presentation, and management options. Int J Womens Health 2015;7:305-13.","DOI":"10.2147\/IJWH.S68979"},{"key":"6800","doi-asserted-by":"crossref","unstructured":"Addison WA, Livengood CH 3rd, Hill GB, et al. Necrotizing fasciitis of vulvar origin in diabetic patients. Obstet Gynecol 1984;63:473-9.","DOI":"10.3109\/00016348409156706"},{"key":"6801","doi-asserted-by":"crossref","unstructured":"Adelson MD, Miranda FR, Strumpf KB. Necrotizing fasciitis: a complication of squamous cell carcinoma of the vulva. Gynecol Oncol 1991;42:98-102.","DOI":"10.1016\/0090-8258(91)90239-2"},{"key":"6802","doi-asserted-by":"crossref","unstructured":"Stephenson H, Dotters DJ, Katz V, Droegemueller W. Necrotizing fasciitis of the vulva. Am J Obstet Gynecol 1992;166:1324-7.","DOI":"10.1016\/0002-9378(92)91597-4"},{"key":"6803","unstructured":"Nakayama J, Busse R. An analysis of vulvar necrotizing fasciitis in the unique and ethnically diverse Hawaiian population. Hawaii Med J 2010;69:13-6."},{"key":"6804","doi-asserted-by":"crossref","unstructured":"Almarzouqi F, Grieb G, Klink C, et al. Fatal Necrotizing Fasciitis following Episiotomy. Case Rep Surg. 2015;2015:562810.","DOI":"10.1155\/2015\/562810"},{"key":"6805","doi-asserted-by":"crossref","unstructured":"Vongsa R, Hoffman D, Shepard K, Koenig D. Comparative study of vulva and abdominal skin microbiota of healthy females with high and average BMI. BMC Microbiol 2019;19:16.","DOI":"10.1186\/s12866-019-1391-0"},{"key":"6806","doi-asserted-by":"crossref","unstructured":"Wong CH, Khin LW, Heng KS, et al. The LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) score: a tool for distinguishing necrotizing fasciitis from other soft tissue infections. Crit Care Med. 2004;32:1535-41.","DOI":"10.1097\/01.CCM.0000129486.35458.7D"},{"key":"6807","doi-asserted-by":"crossref","unstructured":"Tso DK, Singh AK. Necrotizing fasciitis of the lower extremity: imaging pearls and pitfalls. Br J Radiol 2018;91:20180093.","DOI":"10.1259\/bjr.20180093"},{"key":"6808","unstructured":"Riseman JA, Zamboni WA, Curtis A, et al. Hyperbaric oxygen therapy for necrotizing fasciitis reduces mortality and the need for debridements. Surgery 1990;108:847-50."}],"container-title":["Dermatology Reports"],"original-title":[],"link":[{"URL":"https:\/\/www.pagepress.org\/journals\/index.php\/dr\/article\/download\/9082\/8827","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepress.org\/journals\/index.php\/dr\/article\/download\/9082\/8827","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T12:49:47Z","timestamp":1663159787000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pagepress.org\/journals\/index.php\/dr\/article\/view\/9082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,17]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,9,14]]}},"URL":"https:\/\/doi.org\/10.4081\/dr.2022.9082","relation":{},"ISSN":["2036-7406","2036-7392"],"issn-type":[{"value":"2036-7406","type":"electronic"},{"value":"2036-7392","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3,17]]}}}