{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:59:54Z","timestamp":1784563194250,"version":"3.55.0"},"reference-count":15,"publisher":"PAGEPress Publications","issue":"2","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>The major discovery of the novel therapeutic Janus kinase (JAK) inhibitors has been implicated in several dermatological diseases. Recently, studies have shown the efficacy and encouraging results of oral JAK inhibitors as a treatment for alopecia areata (AA). Due to the novelty of this treatment, potential side effects are not fully explored. In this paper, we present a case of a 28-year-old male with a 10-year history of alopecia totalis (AT) treated successfully with tofacitinib with encouraging effects on hair regrowth; however, a significant worsening of the patient\u2019s facial acne was observed four months after AT treatment initiation. JAK inhibitors have promising results in the management of different dermatological conditions including moderatesevere forms of AA with few reported adverse events. Acne exacerbation is a unique observed adverse effect of this therapy. More thorough larger sized studies are needed to further characterize the association between acne exacerbation and the use of JAK inhibitors.<\/jats:p>","DOI":"10.4081\/dr.2022.9396","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T13:57:41Z","timestamp":1655733461000},"source":"Crossref","is-referenced-by-count":8,"title":["Acne exacerbation after tofacitinib treatment for alopecia areata"],"prefix":"10.4081","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6417-6740","authenticated-orcid":false,"given":"Sawsan","family":"Alharthi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6555-4109","authenticated-orcid":false,"given":"Mohammed","family":"Turkmani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1759-1057","authenticated-orcid":false,"given":"Mohammed I.","family":"AlJasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2022,1,1]]},"reference":[{"key":"6407","doi-asserted-by":"crossref","unstructured":"Solimani F, Meier K, Ghoreschi K. Emerging Topical and Systemic JAK Inhibitors in Dermatology. Front Immunol 2019;10:2847.","DOI":"10.3389\/fimmu.2019.02847"},{"key":"6408","doi-asserted-by":"crossref","unstructured":"Damsky W, King BA. JAK inhibitors in dermatology: The promise of a new drug class. J Am Acad Dermatol 2017;76:736-44.","DOI":"10.1016\/j.jaad.2016.12.005"},{"key":"6409","doi-asserted-by":"crossref","unstructured":"Samadi A, Ahmad Nasrollahi S, Hashemi A, et al. Janus kinase (JAK) inhibitors for the treatment of skin and hair disorders: a review of literature. J Dermatol Treat 2017;28:476\u201083.","DOI":"10.1080\/09546634.2016.1277179"},{"key":"6410","unstructured":"Cinats A, Heck E, Robertson L. Janus Kinase Inhibitors: A Review of Their Emerging Applications in Dermatology. Skin Therapy Lett 2018;23:5-9."},{"key":"6411","doi-asserted-by":"crossref","unstructured":"Mahajan S, Hogan JK, Shlyakhter D, et al. VX\u2010509 (decernotinib) is a potent and selective Janus kinase 3 inhibitor that attenuates inflammation in animal models of autoimmune disease. J Pharmacol Exp Ther 201;353:405\u201014.","DOI":"10.1124\/jpet.114.221176"},{"key":"6412","doi-asserted-by":"crossref","unstructured":"Shreberk-Hassidim R, Ramot Y, Zlotogorski A. Janus kinase inhibitors in dermatology: A systematic review. J Am Acad Dermatol 2017;76:745-53.","DOI":"10.1016\/j.jaad.2016.12.004"},{"key":"6413","unstructured":"Ramot Y, Zlotogorski A. [JAK inhibitors for the treatment of alopecia areata]. Harefuah 2020;159:38-42."},{"key":"6414","doi-asserted-by":"crossref","unstructured":"Kontzias A, Laurence A, Gadina M, O'Shea JJ. Kinase inhibitors in the treatment of immune-mediated disease. F1000 Med Rep 2012;4:5.","DOI":"10.3410\/M4-5"},{"key":"6415","doi-asserted-by":"crossref","unstructured":"Jabbari A, Dai Z, Xing L, et al. Reversal of alopecia areata following treatment with the JAK1\/2 inhibitor baricitinib. EBioMedicine 2015;2:351\u20135.","DOI":"10.1016\/j.ebiom.2015.02.015"},{"key":"6416","doi-asserted-by":"crossref","unstructured":"Liu LY, Craiglow BG, Dai F, King BA. Tofacitinib for the treatment of severe alopecia areata and variants: a study of 90 patients. J Am Acad Dermatol 2017;76:22\u20138.","DOI":"10.1016\/j.jaad.2016.09.007"},{"key":"6417","doi-asserted-by":"crossref","unstructured":"Almutairi N, Nour TM, Hussain NH. Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study. Dermatology 2019;235:130-6.","DOI":"10.1159\/000494613"},{"key":"6418","doi-asserted-by":"crossref","unstructured":"Guo L, Feng S, Sun B, et al. Benefit and risk profile of tofacitinib for the treatment of alopecia areata: a systemic review and meta-analysis. J Eur Acad Dermatol Venereol 2020;34:192-201.","DOI":"10.1111\/jdv.15937"},{"key":"6419","doi-asserted-by":"crossref","unstructured":"Tsai HR, Lu JW, Chen LY, Chen TL. Application of Janus Kinase Inhibitors in Atopic Dermatitis: An Updated Systematic Review and Meta-Analysis of Clinical Trials. J Pers Med 2021;11:279.","DOI":"10.3390\/jpm11040279"},{"key":"6420","doi-asserted-by":"crossref","unstructured":"Rothstein B, Joshipura D, Saraiya A, et al. Treatment of vitiligo with the topical Janus kinase inhibitor ruxolitinib. J Am Acad Dermatol 2017;76:1054-60.","DOI":"10.1016\/j.jaad.2017.02.049"},{"key":"6421","doi-asserted-by":"crossref","unstructured":"Awad SM, Tawfik YM, El-Mokhtar MA, et al. Activation of Janus kinase signaling pathway in acne lesions. Dermatol Ther 2021;34:e14563.","DOI":"10.1111\/dth.14563"}],"container-title":["Dermatology Reports"],"original-title":[],"link":[{"URL":"https:\/\/www.pagepress.org\/journals\/index.php\/dr\/article\/download\/9396\/8744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepress.org\/journals\/index.php\/dr\/article\/download\/9396\/8744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T13:58:02Z","timestamp":1655733482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pagepress.org\/journals\/index.php\/dr\/article\/view\/9396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,1]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,6,16]]}},"URL":"https:\/\/doi.org\/10.4081\/dr.2022.9396","relation":{},"ISSN":["2036-7406","2036-7392"],"issn-type":[{"value":"2036-7406","type":"electronic"},{"value":"2036-7392","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1,1]]}}}