{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:55:49Z","timestamp":1770490549285,"version":"3.49.0"},"reference-count":15,"publisher":"PAGEPress Publications","issue":"3","license":[{"start":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T00:00:00Z","timestamp":1643155200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Brooke-Spiegler syndrome is a rare disorder, characterized by the development of skin adnexal tumors, including cylindromas, trichoepitheliomas, spiradenomas. Although these neoplasms are benign in most patients, a malignant transformation can rarely occur. Furthermore, an occasional association between cutaneous adnexal tumors and basal cell adenoma as well as adenocarcinoma of the parotid gland has been rarely described, with approximately 20 cases reported. We report a case of BSS presenting with a malignant eccrine spiradenocylindroma, in a patient with previous history of parotid basal cell tumor.<\/jats:p>","DOI":"10.4081\/dr.2022.9418","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T15:53:55Z","timestamp":1643212435000},"source":"Crossref","is-referenced-by-count":3,"title":["Malignant eccrine spiradenocylindroma and parotid gland involvement in Brooke Spiegler syndrome"],"prefix":"10.4081","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0767-4684","authenticated-orcid":false,"given":"Giulia","family":"Merlo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Pesce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Borra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ileana","family":"Orejuela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Pasquali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renzo","family":"Panizza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Ghiglione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Grosso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2022,1,26]]},"reference":[{"key":"6895","doi-asserted-by":"crossref","unstructured":"Kazakov DV. 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Brooke-spiegler syndrome with multiple scalp cylindromas and bilateral parotid gland adenomas. Case Rep Radiol 2012;2012:249583.","DOI":"10.1155\/2012\/249583"},{"key":"6903","doi-asserted-by":"crossref","unstructured":"Scott AR, Faquin WC, Deschler DG. Parotid mass in a woman with multiple cutaneous cylindromas. Head Neck 2010;32:684-7.","DOI":"10.1002\/hed.21133"},{"key":"6904","doi-asserted-by":"crossref","unstructured":"Grossmann P, Vanecek T, Steiner P, et al. Novel and recurrent germline and somatic mutations in a cohort of 67 patients from 48 families with Brooke-Spiegler syndrome including the phenotypic variant of multiple familial trichoepitheliomas and correlation with the histopathologic findings in 379 biopsy specimens. Am J Dermatopathol 2013;35:34-44.","DOI":"10.1097\/DAD.0b013e31824e7658"},{"key":"6905","doi-asserted-by":"crossref","unstructured":"Blake PW, Toro JR. Update of cylindromatosis gene (CYLD) mutations in Brooke-Spiegler syndrome: novel insights into the role of deubiquitination in cell signaling. Review Hum Mutat 2009;30:1025-36.","DOI":"10.1002\/humu.21024"},{"key":"6906","doi-asserted-by":"crossref","unstructured":"Denadai R, Stelini RF, Roberto WM, et al. Brooke-Spiegler syndrome clinically misdiagnosed as neurofibromatosis type 1. J Craniofac Surg 2015;26:323-5.","DOI":"10.1097\/SCS.0000000000001227"},{"key":"6907","doi-asserted-by":"crossref","unstructured":"Pizinger K, Michal M. Malignant cylindroma in Brooke-Spiegler syndrome. Dermatology 2000;201:255-7.","DOI":"10.1159\/000018499"},{"key":"6908","doi-asserted-by":"crossref","unstructured":"Durani BK, Kurzen H, Jaeckel A, et al. Malignant transformation of multiple dermal cylindromas. Br J Dermatol 2001;145:653-6.","DOI":"10.1046\/j.1365-2133.2001.04460.x"},{"key":"6909","doi-asserted-by":"crossref","unstructured":"K\u00f6stler E, J Sch\u00f6nlebe, T Mentzel, et al. 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