{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T12:08:39Z","timestamp":1747224519550,"version":"3.40.5"},"reference-count":15,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Trichilemmal cysts constitute the second most common cutaneous cysts and are mostly presented on the scalp of middle aged women. It is, therefore, unusual for a young person to have a trichilemmal cyst and it is extremely rare for a trichilemmal cyst to be ossified. In literature, only 8 cases of trichilemmal cysts with concomitant ossification have been described. We report the case of a 22 year old female who presented with a scalp nodule and was treated via surgical excision of the lesion. The pathology examination of the surgical specimen revealed a lesion consisting of a multilayered squamous epithelium of slightly eosinophilic maturing keratinocytes. There was no granular layer, whereas the core of the lesion was occupied by mature bone tissue with calcium deposits. The definite diagnosis of the pathology report was ossifying trichilemmal cyst. The aim of this report is, to enlighten clinicians about this rare pathological entity.<\/jats:p>","DOI":"10.4081\/dr.2022.9569","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T12:26:20Z","timestamp":1663331180000},"source":"Crossref","is-referenced-by-count":0,"title":["A rare ossifying trichilemmal cyst in a young female patient: Case report and literature review"],"prefix":"10.4081","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8928-1029","authenticated-orcid":false,"given":"Evanthia","family":"Serpetsidaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis G.","family":"Gkionis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxani","family":"Arvelaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zafeiro I.","family":"Karafoulidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasios F.","family":"Dimou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Kafousi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"6926","doi-asserted-by":"crossref","unstructured":"Pusiol T, Morichetti D, Zorzi MG, Francesco P. Ossifying trichilemmal cyst. Am J Dermatopathol. 2011;33:867-8","DOI":"10.1097\/DAD.0b013e31821b0abd"},{"key":"6927","doi-asserted-by":"crossref","unstructured":"Kamyab K, Kianfar N, Dasdar S et al. Cutaneous cysts: a clinicopathologic analysis of 2,438 cases. Int J Dermatol. 2020;59:457-62","DOI":"10.1111\/ijd.14808"},{"key":"6928","doi-asserted-by":"crossref","unstructured":"Kolodney MS, Coman GC, Smolkin MB et al. Hereditary trichilemmal cysts are caused by two hits to the same copy of the phospholipase c delta 1 gene (PLCD1). Sci Rep. 2020;10:6035","DOI":"10.1038\/s41598-020-62959-z"},{"key":"6929","doi-asserted-by":"crossref","unstructured":"H\u00f6rer S, Marrakchi S, Radner FP et al. A monoallelic two-hit mechanism in PLCD1 explains the genetic pathogenesis of hereditary trichilemmal cyst formation. J Invest Dermatol. 2019;139:2154-63","DOI":"10.1016\/j.jid.2019.04.015"},{"key":"6930","doi-asserted-by":"crossref","unstructured":"Baldovini C, Rosini F, Marucci G. Osseous metaplasia and mature bone formation with extramedullary hematopoiesis in trichilemmal cyst. Am J Dermatopathol. 2014;36:444-6","DOI":"10.1097\/DAD.0b013e31828a31d5"},{"key":"6931","doi-asserted-by":"crossref","unstructured":"Fletcher CD. Calcifying and ossifying soft tissue lesions presenting in the skin. J Cutan Pathol. 1996;23:297","DOI":"10.1111\/j.1600-0560.1996.tb01300.x"},{"key":"6932","unstructured":"Civatte J, Tso\u00eftis G, Le Roux P. Perforating ossified (trichilemmal) \"sebaceous\" cyst. Apropos of a case. Ann Dermatol Syphiligr (Paris) 1974;101:155-70"},{"key":"6933","doi-asserted-by":"crossref","unstructured":"Mommers XA, Henault B, Aubriot MH et al. Multiple ossifying trichilemmal cysts of the scalp: a familial case. Rev Stomatol Chir Maxillofac. 2012;113:53-6","DOI":"10.1016\/j.stomax.2011.10.008"},{"key":"6934","doi-asserted-by":"crossref","unstructured":"B\u00e4r M, Kayser DM, Trnikov\u00e1 M, Grunow N. Perforating and ruptured trichilemmal cyst with metaplastic ossification. Pathologe. 2012;33:459-62","DOI":"10.1007\/s00292-012-1589-5"},{"key":"6935","doi-asserted-by":"crossref","unstructured":"Bulut A\u015e. Trichilemmal cyst with ossification and marrow formation: a case report. J Turk Acad Dermatol. 2012;6:1263c4","DOI":"10.6003\/jtad1263c4"},{"key":"6936","doi-asserted-by":"crossref","unstructured":"Abreu Velez AM, Brown VM, Howard MS. An inflamed trichilemmal (pilar) cyst: not so simple? N Am J Med Sci. 2011;3:431-4","DOI":"10.4297\/najms.2011.3431"},{"key":"6937","doi-asserted-by":"crossref","unstructured":"He P, Chen W, Zhang Q et al. Distinguishing a trichilemmal cyst from a pilomatricoma with ultrasound. J Ultrasound Med. 2020; 39:1939-45","DOI":"10.1002\/jum.15298"},{"key":"6938","doi-asserted-by":"crossref","unstructured":"Singh P, Usman A, Motta L, Khan I. Malignant proliferating trichilemmal tumour. BMJ Case Rep. 2018;2018:bcr2018224460","DOI":"10.1136\/bcr-2018-224460"},{"key":"6939","doi-asserted-by":"crossref","unstructured":"Osto M, Parry N, Rehman R et al. Malignant proliferating trichilemmal tumor of the scalp: a systematic review. Am J Dermatopathol. 2021;43:851-66","DOI":"10.1097\/DAD.0000000000001991"},{"key":"6940","doi-asserted-by":"crossref","unstructured":"Anolik R, Firoz B, Walters RF et al. Proliferating trichilemmal cyst with focal calcification. 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