{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T20:44:55Z","timestamp":1757450695394,"version":"3.40.5"},"reference-count":20,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Treatment of disseminated granuloma annulare (GA) can be challenging and there is no gold standard for treatment.\u00a0 We observed two cases of generalized GA that had been resistant to other treaments successfully treated with canary seed milk. Canary seed milk has antioxidant (contains vitamin E), anti-diabetic (DPP-4 inhibition), and anti-hypertensive (ACE inhibition) properties. Therefore, dermatologists can consider alpiste milk as a sole or supplemental treatment for patients with GA with or without comorbidities such as diabetes and hypertension, in GA patients who prefer alternative therapy or failed other treatments.\u00a0<\/jats:p>","DOI":"10.4081\/dr.2023.9614","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T14:05:10Z","timestamp":1671804310000},"source":"Crossref","is-referenced-by-count":2,"title":["Effects of canary seed on two patients with disseminated granuloma annulare"],"prefix":"10.4081","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7465-5224","authenticated-orcid":false,"given":"Lily","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey","family":"Arutyunyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Vasile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"8447","doi-asserted-by":"crossref","unstructured":"Wu W, Robinson-Bostom L, Kokkotou E, Jung HY, Kroumpouzos G. 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Granuloma annulare: Pathogenesis, disease associations and triggers, and therapeutic options. J Am Acad Dermatol. 2016;75(3):467-479. doi:10.1016\/j.jaad.2015.03.055","DOI":"10.1016\/j.jaad.2015.03.055"},{"key":"8451","doi-asserted-by":"crossref","unstructured":"Estrada-Salas PA, Montero-Mor\u00e1n GM, Mart\u00ednez-Cuevas PP, Gonz\u00e1lez C, Barba de la Rosa AP. Characterization of antidiabetic and antihypertensive properties of canary seed (Phalaris canariensis L.) peptides. J Agric Food Chem. 2014;62(2):427-433. doi:10.1021\/jf404539y","DOI":"10.1021\/jf404539y"},{"key":"8452","doi-asserted-by":"crossref","unstructured":"Abdel-Aal el-SM, Hucl P, Patterson CA, Gray D. Fractionation of hairless canary seed (Phalaris canariensis) into starch, protein, and oil. J Agric Food Chem. 2010;58(11):7046-7050. doi:10.1021\/jf100736m","DOI":"10.1021\/jf100736m"},{"key":"8453","doi-asserted-by":"crossref","unstructured":"Capuano A, Sportiello L, Maiorino MI, Rossi F, Giugliano D, Esposito K. 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