{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:28:18Z","timestamp":1765268898522,"version":"3.40.5"},"reference-count":15,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Hailey-Hailey disease (HHD) or familial benign pemphigus is a rare genetic condition, characterized by recurrent blisters and erosions, with a predilection for intertriginous areas. There is no specific treatment for HHD. Topical and systemic treatment tends to provide temporary remission. Alternative treatment (surgical interventions, such as dermabrasion, excision, and laser) has been shown to prolong remission. Considering the risk of complications associated with surgical modalities, laser is often preferred as an alternative for patients failing to respond to first-line therapies. We report a case of recalcitrant HHD successfully treated with a fractional ablative CO2 laser procedure (wavelength of 10600 nm, power of 7-10 W, 2-3 passes) on a 35-year-old female. The patient has a seven-year history of therapy-resistant HHD. A 2-month follow-up showed substantially resolved lesions, with mild erythema and post-inflammatory hyperpigmentation in treated areas.<\/jats:p>","DOI":"10.4081\/dr.2023.9658","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T14:14:29Z","timestamp":1682086469000},"source":"Crossref","is-referenced-by-count":3,"title":["A case report of Hailey-Hailey disease treated with fractional carbon dioxide laser"],"prefix":"10.4081","author":[{"given":"Zivile","family":"Gabdrafike","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Blazeviciute","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3924-5406","authenticated-orcid":false,"given":"Ugne","family":"Janonyte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurgita","family":"Makstiene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Skaidra","family":"Valiukeviciene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"10268","doi-asserted-by":"crossref","unstructured":"Hailey H, Hailey H. Familial benign chronic pemphigus. Arch Dermatol Syphilol 1939;39:679-685.","DOI":"10.1001\/archderm.1939.01480220064005"},{"key":"10269","unstructured":"Chiaravalloti A, Payette M. Hailey-Hailey disease and review of management. J Drugs Dermatol 2014;13:1254-1257."},{"key":"10270","unstructured":"Patel VM, Rubins S, Schwartz RA et al. Hailey-Hailey disease: a diagnostic challenge. Cutis 2019;103:157-159."},{"key":"10271","doi-asserted-by":"crossref","unstructured":"Farahnik B, Blattner CM, Mortazie MB et al. Interventional treatments for Hailey Hailey disease. J Am Acad Dermatol. 2017;76:551-558.","DOI":"10.1016\/j.jaad.2016.08.039"},{"key":"10272","doi-asserted-by":"crossref","unstructured":"Ben Lagha I, Ashack K, Khachemoune A. Hailey-Hailey Disease: An Update Review with a Focus on Treatment Data. Am J Clin Dermatol 2020;21:49-68.","DOI":"10.1007\/s40257-019-00477-z"},{"key":"10273","doi-asserted-by":"crossref","unstructured":"Pretel-Irazabal M, Lera-Imbuluzqueta JM, Espana-Alonso A. Carbon dioxide laser treatment in Hailey-Hailey disease: a series of 8 patients. Actas Dermosifiliogr 2013;104:325-333.","DOI":"10.1016\/j.adengl.2013.03.004"},{"key":"10274","doi-asserted-by":"crossref","unstructured":"Kruppa A, Korge B, Lasch J et al. Successful treatment of Hailey-Hailey disease with a scanned carbon dioxide laser. Acta Derm Venereol 2000;80:53-54","DOI":"10.1080\/000155500750012568"},{"key":"10275","doi-asserted-by":"crossref","unstructured":"Falto-Aizpurua LA, Griffith RD, Yazdani Abyaneh MA et al. Laser therapy for the treatment of Hailey-Hailey disease: a systematic review with focus on carbon dioxide laser resurfacing. J Eur Acad Dermatol Venereol 2015;29:1045-52","DOI":"10.1111\/jdv.12875"},{"key":"10276","doi-asserted-by":"crossref","unstructured":"Campuzano-Garc\u00eda AE, Torres-Alvarez B, Hern\u00e1ndez-Blanco D et al. Hailey-Hailey disease improved by fractional CO2 laser. J Cosmet Laser Ther 2015;17:213-5.","DOI":"10.3109\/14764172.2015.1007063"},{"key":"10277","doi-asserted-by":"crossref","unstructured":"Gr\u00f6nemeyer LL, Thoms KM, Bertsch HP et al. Reflectance confocal microscopy and Hailey-Hailey disease: assessment of response to treatment after CO2 laser ablation. J Dtsch Dermatol Ges 2014;12:1135-7.","DOI":"10.1111\/ddg.12503"},{"key":"10278","doi-asserted-by":"crossref","unstructured":"Vilela VN, Carvalho CGS, Carvalho GSM et al. Treatment of the Hailey-Hailey disease with fractional CO2 laser: a three-case series. Surg Cosmet Dermatol 2017;9:91-3.","DOI":"10.5935\/scd1984-8773.201791895"},{"key":"10279","doi-asserted-by":"crossref","unstructured":"Ortiz AE, Zachary CB. Laser therapy for Hailey-Hailey disease: review of the literature and a case report. Dermatol Reports 2011;3:e28.","DOI":"10.4081\/dr.2011.e28"},{"key":"10280","doi-asserted-by":"crossref","unstructured":"Hochwalt PC, Christensen KN, Cantwell SR et al. Carbon dioxide laser treatment for Hailey-Hailey disease: a retrospective chart review with patient-reported outcomes. Int J Dermatol 2015;54:1309-14.","DOI":"10.1111\/ijd.12991"},{"key":"10281","doi-asserted-by":"crossref","unstructured":"Touma DJ, Krauss M, Feingold DS et al. Benign familial pemphigus (Hailey-Hailey disease). Treatment with the pulsed carbon dioxide laser. Dermatol Surg 1998;24:1411-4.","DOI":"10.1111\/j.1524-4725.1998.tb00025.x"},{"key":"10282","doi-asserted-by":"crossref","unstructured":"Christian MM, Moy RL. Treatment of Hailey-Hailey disease (or benign familial pemphigus) using short pulsed and short dwell time carbon dioxide lasers. Dermatol Surg 1999;25:661-3.","DOI":"10.1046\/j.1524-4725.1999.99025.x"}],"container-title":["Dermatology Reports"],"original-title":[],"link":[{"URL":"https:\/\/www.pagepress.org\/journals\/index.php\/dr\/article\/download\/9658\/9063","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepress.org\/journals\/index.php\/dr\/article\/download\/9658\/9063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T14:16:05Z","timestamp":1682086565000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pagepress.org\/journals\/index.php\/dr\/article\/view\/9658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,21]]},"references-count":15,"URL":"https:\/\/doi.org\/10.4081\/dr.2023.9658","relation":{},"ISSN":["2036-7406","2036-7392"],"issn-type":[{"type":"electronic","value":"2036-7406"},{"type":"print","value":"2036-7392"}],"subject":[],"published":{"date-parts":[[2023,4,21]]}}}