{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T12:08:59Z","timestamp":1747224539404,"version":"3.40.5"},"reference-count":42,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Psoriasis, a chronic inflammatory skin disorder affects people worldwide and is associated with the HLA-Cw6 allele which varies across ethnicities, and is higher in Caucasians than in Asians. We investigated the HLA-Cw6 prevalence in Vietnamese patients with psoriasis and its correlation with onset age and disease severity. We examined the association between HLA-Cw6 and the clinical features in 121 patients with psoriasis and 30 healthy controls and observed that HLA-Cw6 was significantly higher in patients with psoriasis (64.5%) than in the controls (26.7%) (p=0.0001) with an OR of 4.98 (2.04\u201312.15). The mean age of psoriasis onset was significantly lower in patients with positive HLA-Cw6 than those with negative HLA-Cw6. The AA genotype was more common in patients with mild psoriasis (100%), whereas the TA genotype was prevalent in patients with moderate and severe psoriasis (47.2% and 59.0%, respectively) and in those with high PASI scores (55.1% and 54.1%, respectively). Hence, HLA-Cw6 is a major genetic risk factor for psoriasis in Vietnamese patients, with higher prevalence in patients with early-onset disease. Furthermore, different HLA-Cw6 genotypes are associated with different disease severities.<\/jats:p>","DOI":"10.4081\/dr.2023.9854","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T13:48:58Z","timestamp":1697464138000},"source":"Crossref","is-referenced-by-count":0,"title":["HLA-Cw6 increases the risk of psoriasis and early onset before twenty-seven years of age among the Vietnamese population"],"prefix":"10.4081","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3976-9963","authenticated-orcid":false,"given":"Nhi Thi Uyen","family":"Pham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuong Van","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7732-0497","authenticated-orcid":false,"given":"Hao Trong","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"13455","doi-asserted-by":"crossref","unstructured":"Armstrong AW, Mehta MD, Schupp CW, et al. Psoriasis Prevalence in Adults in the United States. JAMA Dermatol. 2021;157:940\u2013946. doi: 10.1001\/jamadermatol.2021.2007.","DOI":"10.1001\/jamadermatol.2021.2007"},{"key":"13456","doi-asserted-by":"crossref","unstructured":"Rapp SR, Feldman SR, Exum ML, et al.. Psoriasis causes as much disability as other major medical diseases. J Am Acad Dermatol. 1999;41:401\u2013407. doi: 10.1016\/s0190-9622(99)70112-x.","DOI":"10.1016\/S0190-9622(99)70112-X"},{"key":"13457","doi-asserted-by":"crossref","unstructured":"Chen, L. and T.F. Tsai. HLA-Cw6 and psoriasis. Br J Dermatol. 2018;178: 854-862. doi: 10.1111\/bjd.16083. Epub 2018 Mar 2.","DOI":"10.1111\/bjd.16083"},{"key":"13458","unstructured":"Zhang XJ, Zhang AP, Yang S et al. Association of HLA class I alleles with psoriasis"},{"key":"13459","doi-asserted-by":"crossref","unstructured":"vulgaris in southeastern Chinese Hans. J Dermatol Sci. 2003; 33: 1\u20136 doi: 10.1016\/s0923-1811(03)00157-9.","DOI":"10.1016\/S0923-1811(03)00157-9"},{"key":"13460","unstructured":"Fan X, Yang S, Sun LD et al. Comparison of clinical features of HLA-Cw*0602-"},{"key":"13461","unstructured":"positive and -negative psoriasis patients in a Han Chinese population. Acta Derm"},{"key":"13462","doi-asserted-by":"crossref","unstructured":"Venereol. 2007; 87: 335\u201340. doi: 10.2340\/00015555-0253.","DOI":"10.2340\/00015555-0253"},{"key":"13463","unstructured":"Asahina A, Akazaki S, Nakagawa H et al. Specific nucleotide sequence of HLA-C is"},{"key":"13464","doi-asserted-by":"crossref","unstructured":"strongly associated with psoriasis vulgaris. J Invest Dermatol. 1990; 97: 254\u201358. doi: 10.1111\/1523-1747.ep12480361.","DOI":"10.1111\/1523-1747.ep12480361"},{"key":"13465","unstructured":"Nakagawa H, Asahina A, Akazaki S et al. Association of Cw11 in Japanese patients"},{"key":"13466","doi-asserted-by":"crossref","unstructured":"with psoriasis vulgaris. Tissue Antigens. 1990; 36: 241-2. doi: 10.1111\/j.1399-0039.1990.tb01835.x.","DOI":"10.1111\/j.1399-0039.1990.tb01835.x"},{"key":"13467","unstructured":"Kim TG, Lee HJ, Youn JI et al. The association of psoriasis with human leukocyte"},{"key":"13468","unstructured":"antigens in the Korean population and the influence of age of onset and sex. J Invest"},{"key":"13469","doi-asserted-by":"crossref","unstructured":"Dermatol. 2000; 114: 309\u201313. doi: 10.1046\/j.1523-1747.2000.00863.x.","DOI":"10.1046\/j.1523-1747.2000.00863.x"},{"key":"13470","unstructured":"Queiro R, Torre JC, Gonz\u00e1lez S, et al. HLA antigens may influence the age of onset of psoriasis and psoriatic arthritis. J Rheumatol. 2003;30:505\u2013507."},{"key":"13471","doi-asserted-by":"crossref","unstructured":"Enerb\u00e4ck C, Martinsson T, Inerot A, et al. Evidence that HLA-Cw6 determines early onset of psoriasis, obtained using sequence-specific primers (PCR-SSP). Acta Derm Venereol. 1997;77:273\u2013276. doi: 10.2340\/0001555577273276.","DOI":"10.2340\/0001555577273276"},{"key":"13472","doi-asserted-by":"crossref","unstructured":"Christensen TE, Callis KP, Papenfuss J, et al. Observations of psoriasis in the absence of therapeutic intervention identifies two unappreciated morphologic variants, thin-plaque and thick-plaque psoriasis, and their associated phenotypes. J Invest Dermatol. 2006;126:2397\u20132403. doi: 10.1038\/sj.jid.5700489. Epub 2006 Jul 20.","DOI":"10.1038\/sj.jid.5700489"},{"key":"13473","doi-asserted-by":"crossref","unstructured":"Nair RP, Stuart PE, Nistor I, et al. Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am J Hum Genet. 2006; 78: 827\u2013851. doi: 10.1086\/503821. Epub 2006 Mar 31.","DOI":"10.1086\/503821"},{"key":"13474","unstructured":"Kastelan M, Gruber F, Cecuk E, et al. Analysis of HLA antigens in Croatian patients"},{"key":"13475","doi-asserted-by":"crossref","unstructured":"with psoriasis. Acta Derm Venereol Suppl (Stockh). 2000; 211: 12\u20133. doi: 10.1080\/00015550050500040.","DOI":"10.1080\/00015550050500040"},{"key":"13476","unstructured":"Gonzalez S, Martinez-Borra J, Torre-Alonso JC, et al. The MICA-A9 triplet repeat"},{"key":"13477","doi-asserted-by":"crossref","unstructured":"polymorphism in the transmembrane region confers additional susceptibility to the development of psoriatic arthritis and is independent of the association of Cw*0602 in psoriasis. Arthritis Rheum. 1999; 42: 1010\u20136. doi: 10.1002\/1529-0131(199905)42:5<1010::AID-ANR21>3.0.CO;2-H.","DOI":"10.1002\/1529-0131(199905)42:5<1010::AID-ANR21>3.0.CO;2-H"},{"key":"13478","unstructured":"Martinez-Borra J, Brautbar C, Gonzalez S, et al. The region of 150 kb telometic to"},{"key":"13479","doi-asserted-by":"crossref","unstructured":"HLA-C is associated with psoriasis in the Jewish population. J Invest Dermatol. 2005; 125: 928\u201332. doi: 10.1111\/j.0022-202X.2005.23892.x.","DOI":"10.1111\/j.0022-202X.2005.23892.x"},{"key":"13480","doi-asserted-by":"crossref","unstructured":"Gudjonsson JE, Karason A, Antonsdottir A, et al. Psoriasis patients who are homozygous for the HLA-Cw*0602 allele have a 2.5-fold increased risk of developing psoriasis compared with Cw6 heterozygotes. Br J Dermatol. 2003; 148:","DOI":"10.1046\/j.1365-2133.2003.05115.x"},{"key":"13481","doi-asserted-by":"crossref","unstructured":"\u20135. doi: 10.1046\/j.1365-2133.2003.05115.x.","DOI":"10.1046\/j.1365-2133.2003.05115.x"},{"key":"13482","unstructured":"Rani R, Narayan R, Fernandez-Vina MA, et al. Role of HLA-B and C alleles in"},{"key":"13483","doi-asserted-by":"crossref","unstructured":"development of psoriasis in patients from North India. Tissue Antigens. 1998; 51: 618\u2013","DOI":"10.1111\/j.1399-0039.1998.tb03004.x"},{"key":"13484","doi-asserted-by":"crossref","unstructured":"doi: 10.1111\/j.1399-0039.1998.tb03004.x.","DOI":"10.1111\/j.1399-0039.1998.tb03004.x"},{"key":"13485","unstructured":"Chandra A, Lahiri A, Senapati S, et al. Increased risk of psoriasis due to combined"},{"key":"13486","doi-asserted-by":"crossref","unstructured":"effect of HLA-Cw6 and LCE3 risk alleles in Indian population. Sci Rep. 2016; 6: 24059. doi: 10.1038\/srep24059.","DOI":"10.1038\/srep24059"},{"key":"13487","unstructured":"Indhumathi S, Rajappa M, Chandrashekar L, et al. The HLA-C*06 allele as a possible"},{"key":"13488","doi-asserted-by":"crossref","unstructured":"genetic predisposing factor to psoriasis in South Indian Tamils. Arch Dermatol Res. 2016; 308: 193\u20139. doi: 10.1007\/s00403-016-1618-y. Epub 2016 Jan 21.","DOI":"10.1007\/s00403-016-1618-y"},{"key":"13489","unstructured":"Tsai TF, Hu CY, Tsai WL, et al. HLA-Cw6 specificity and polymorphic residues are"},{"key":"13490","unstructured":"associated with susceptibility among Chinese psoriatics in Taiwan. Arch Dermatol"},{"key":"13491","doi-asserted-by":"crossref","unstructured":"Res. 2002; 294: 214\u201320. doi: 10.1007\/s00403-002-0324-0. Epub 2002 Jun 13.","DOI":"10.1007\/s00403-002-0324-0"},{"key":"13492","doi-asserted-by":"crossref","unstructured":"Chang YT, Tsai SF, Lee DD, et al. A study of candidate genes for psoriasis near HLAC in Chinese patients with psoriasis. Br J Dermatol. 2003; 148: 418\u201323. doi: 10.1046\/j.1365-2133.2003.05166.x.","DOI":"10.1046\/j.1365-2133.2003.05166.x"},{"key":"13493","unstructured":"Chang YT, Tsai SF, Lin MW, et al. SPR1 gene near HLA-C is unlikely to be a"},{"key":"13494","doi-asserted-by":"crossref","unstructured":"psoriasis susceptibility gene. Exp Dermatol. 2003; 12: 307\u201314. doi: 10.1034\/j.1600-0625.2003.00039.x.","DOI":"10.1034\/j.1600-0625.2003.00039.x"},{"key":"13495","unstructured":"Henseler T, Christophers E. Psoriasis of early and late onset: characterization of two"},{"key":"13496","doi-asserted-by":"crossref","unstructured":"types of psoriasis vulgaris. 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