{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T12:09:00Z","timestamp":1747224540073,"version":"3.40.5"},"reference-count":30,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Background. Hand eczema (HE) commonly occurs in healthcare services, especially during COVID-19 pandemic era. Vitamin D shows various effects on skin inflammation. This study aims to analyze the correlation between HE severity and vitamin D levels as measured by serum 25(OH)D in healthcare workers. Method. This is an analytic descriptive study with a cross-sectional design conducted in Indonesia between September-October 2022. HE severity was assessed using Hand Eczema Severity Index (HECSI). Results. Among 44 healthcare workers with HE, 29 people had mild HE, 11 had moderate HE, and 4 had severe HE. The mean serum 25(OH)D level in subjects with mild, moderate, and severe HE was 17.85 ng\/mL, 16.45 ng\/mL, and 17.87 ng\/mL, respectively, which belonged to vitamin D deficiency category. There was no statistically significant correlation between serum 25(OH)D levels and HE severity (r = -0.056; p = 0.359). Conclusions. There was no significant difference in serum 25(OH)D levels between subjects with mild, moderate, and severe HE. Serum 25(OH)D level was not inversely correlated with HE severity.<\/jats:p>","DOI":"10.4081\/dr.2023.9861","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T09:30:21Z","timestamp":1698226221000},"source":"Crossref","is-referenced-by-count":0,"title":["Correlation between serum 25(OH)D levels with severity of work-related hand eczema among healthcare workers: a cross-sectional study"],"prefix":"10.4081","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5064-3317","authenticated-orcid":false,"given":"Danny","family":"Surya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melani","family":"Marissa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Windy Keumala","family":"Budianti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahadi","family":"Rihatmadja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge Ade","family":"Krisanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dewi","family":"Friska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7347-8959","authenticated-orcid":false,"given":"Sandra","family":"Widaty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2023,10,25]]},"reference":[{"key":"13297","doi-asserted-by":"crossref","unstructured":"Capucci S, Hahn-Pedersen J, Vilsboll A, Kragh N. Impact of atopic dermatitis and chronic hand eczema on quality of life compared with other chronic diseases. Dermatitis. 2020;31:178-84.","DOI":"10.1097\/DER.0000000000000598"},{"key":"13298","doi-asserted-by":"crossref","unstructured":"Quaade AS, Simonsen AB, Halling AS, et al. Prevalence, incidence, and severity of hand eczema in the general population - A systematic review and meta-analysis. Contact Dermatitis. 2021;84:361-74.","DOI":"10.1111\/cod.13804"},{"key":"13299","doi-asserted-by":"crossref","unstructured":"Yusuf RS, Qurratuaini BPA, Hidajat D. Efek hand hygiene terhadap dermatitis tangan. JKU Unram. 2021;10:480-6.","DOI":"10.29303\/jku.v10i2.505"},{"key":"13300","doi-asserted-by":"crossref","unstructured":"Rundle CW, Presley CL, Militello M, et al. Hand hygiene during COVID-19: Recommendations from the American Contact Dermatitis Society. J Am Acad Dermatol. 2020;83:1730-7.","DOI":"10.1016\/j.jaad.2020.07.057"},{"key":"13301","unstructured":"Sawitri, Astindari, Yuindartanto A, et al. Epidemiology of occupational contact dermatitis (OCD) on health workers in Covid-19. J Pak Assoc Dermatol. 2023;33:220-34."},{"key":"13302","doi-asserted-by":"crossref","unstructured":"Samanta S. Vitamin D and immunomodulation in the skin: A useful affirmative nexus. Exploration of Immunology. 2021.","DOI":"10.37349\/ei.2021.00009"},{"key":"13303","doi-asserted-by":"crossref","unstructured":"Amon U, Baier L, Yaguboglu R, et al. Serum 25-hydroxyvitamin D levels in patients with skin diseases including psoriasis, infections, and atopic dermatitis. Dermatoendocrinol. 2018;10:e1442159.","DOI":"10.1080\/19381980.2018.1442159"},{"key":"13304","doi-asserted-by":"crossref","unstructured":"Suryadinata RV, Lorensia A, Aprilia AP. Profil vitamin D pada pasien asma dan non-asma dewasa di Surabaya. 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J of IMAB. 2017;23:1490-4.","DOI":"10.5272\/jimab.2017231.1490"},{"key":"13309","doi-asserted-by":"crossref","unstructured":"Madan I, Parsons V, Cookson B, et al. A behavioural change package to prevent hand dermatitis in nurses working in the national health service (the SCIN trial): study protocol for a cluster randomised controlled trial. Trials. 2016;17:145.","DOI":"10.1186\/s13063-016-1255-y"},{"key":"13310","doi-asserted-by":"crossref","unstructured":"Celik V, Ozkars MY. An overlooked risk for healthcare workers amid COVID-19: Occupational hand eczema. North Clin Istanb. 2020;7:527-33.","DOI":"10.14744\/nci.2020.45722"},{"key":"13311","doi-asserted-by":"crossref","unstructured":"Techasatian L, Thaowandee W, Chaiyarit J, et al. Hand hygiene habits and prevalence of hand eczema during the COVID-19 pandemic. J Prim Care Community Health. 2021;12:1-5.","DOI":"10.1177\/21501327211018013"},{"key":"13312","doi-asserted-by":"crossref","unstructured":"Loh EW, Yew YW. Hand hygiene and hand eczema: A systematic review and meta-analysis. Contact Dermatitis. 2022.","DOI":"10.1111\/cod.14133"},{"key":"13313","doi-asserted-by":"crossref","unstructured":"Nopriyati, Trilisnawati D, Yulia Farida Y, et al. Prevention of irritant contact dermatitis due to hand hygiene in the era of COVID 19 pandemic. BSM. 2020;4:29-44.","DOI":"10.32539\/bsm.v4i4.160"},{"key":"13314","doi-asserted-by":"crossref","unstructured":"Desira ADD, Riyanto P, Afriliana L, Adespin DA. Relationship of hand sanitizer usage frequency with the incidence of irritant contact dermatitis during Covid-19 pandemic. JKD. 2022;11:109-13.","DOI":"10.14710\/dmj.v11i2.32631"},{"key":"13315","doi-asserted-by":"crossref","unstructured":"Kodik MS, \u00c7etin ZD, Unal \u0130, Altunc\u0131 YA. The prevalence and risk factors of hand eczema among emergency healthcare workers during the COVID-19 pandemic. 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The moderate correlation between 25(OH)D serum and saliva in healthy people with low vitamin D intake. Int J Gen Med. 2021;14:841-50.","DOI":"10.2147\/IJGM.S302912"},{"key":"13324","doi-asserted-by":"crossref","unstructured":"Methkal AM, Kuts LV. The investigation of the dependence between hand eczema severity and some cytokine profile parameters, vitamin D level, and glucocorticoid receptor gene polymorphism. Ukra\u00efns\u02b9kij \u017eurnal medicini, b\u00ecolog\u00ec\u00ef ta sportu. 2020;5:164-9.","DOI":"10.26693\/jmbs05.05.164"},{"key":"13325","doi-asserted-by":"crossref","unstructured":"Huang CM, Lara-Corrales I, Pope E. Effects of vitamin D levels and supplementation on atopic dermatitis: A systematic review. Pediatr Dermatol. 2018;35:754-60.","DOI":"10.1111\/pde.13639"},{"key":"13326","doi-asserted-by":"crossref","unstructured":"Hafsia M, Kacem I, El Maalel O, et al. Relationship between hand eczema severity and occupational stress: A cross-sectional study. 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