{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T12:09:04Z","timestamp":1747224544421,"version":"3.40.5"},"reference-count":14,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Actinic keratoses (AKs) are common skin lesions found on sun-exposed areas and are considered potential precursors to squamous cell carcinomas (SCCs). This observational case-control study evaluates the efficacy of combining traditional daylight photodynamic therapy (DL-PDT) with pre-treatment using 0.005% calcipotriol (CAL) ointment. Twenty immunocompetent male patients with grade I-II AKs on the scalp and\/or face were randomized into two groups: the case group received a 14-day pretreatment with CAL ointment before DL-PDT, while the control group used a moisturizing cream. Both groups underwent a series of three DL-PDT sessions. The study utilized the Actinic Keratosis Area Severity Index (AKASI) scoring system to measure the actinic damage at baseline, 3 months, and 6 months post-treatment. Results showed a significant reduction in AKASI scores in the CAL group compared to controls, indicating that CAL pretreatment enhances the efficacy of DL-PDT. This combination treatment was well tolerated, with minimal discomfort reported. The findings suggest that incorporating CAL into the treatment regimen can improve the clearance of AKs and potentially prevent their progression to SCCs.<\/jats:p>","DOI":"10.4081\/dr.2024.10077","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T13:14:19Z","timestamp":1727788459000},"source":"Crossref","is-referenced-by-count":0,"title":["Calcipotriol as a daylight photodynamic therapy enhancer: a case-control study"],"prefix":"10.4081","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6892-1445","authenticated-orcid":false,"given":"Benedetta","family":"Sonego","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9276-3627","authenticated-orcid":false,"given":"Enrico","family":"Zelin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Bonin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Pozzebon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8135-7025","authenticated-orcid":false,"given":"Giulia","family":"Bazzacco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7296-4583","authenticated-orcid":false,"given":"Andrea","family":"Corio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3753-1724","authenticated-orcid":false,"given":"Marina","family":"Agozzino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dante Raffaele","family":"Caro Caposieno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7878-4955","authenticated-orcid":false,"given":"Iris","family":"Zalaudek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Di Meo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"key":"19429","doi-asserted-by":"crossref","unstructured":"Flohil SC, van der Leest RJ, Dowlatshahi EA, et al. Prevalence of actinic keratosis and its risk factors in the general population: the Rotterdam Study. J Invest Dermatol 2013;133:1971-8.","DOI":"10.1038\/jid.2013.134"},{"key":"19430","doi-asserted-by":"crossref","unstructured":"Criscione VD, Weinstock MA, Naylor MF, et al. Actinic keratoses: natural history and risk of malignant transformation in the Veterans Affairs Topical Tretinoin Chemoprevention Trial. Cancer 2009;115:2523-30.","DOI":"10.1002\/cncr.24284"},{"key":"19431","doi-asserted-by":"crossref","unstructured":"Boone MA, Suppa M, Marneffe A, et al. A new algorithm for the discrimination of actinic keratosis from normal skin and squamous cell carcinoma based on in vivo analysis of optical properties by high-definition optical coherence tomography. J Eur Acad Dermatol Venereol 2016;30:1714-25.","DOI":"10.1111\/jdv.13720"},{"key":"19432","doi-asserted-by":"crossref","unstructured":"Worley B, Harikumar V, Reynolds K, et al. Treatment of actinic keratosis: a systematic review. Arch Dermatol Res 2023;315:1099-108.","DOI":"10.1007\/s00403-022-02490-5"},{"key":"19433","doi-asserted-by":"crossref","unstructured":"Dianzani C, Conforti C, Giuffrida R, et al. Current therapies for actinic keratosis. Int J Dermatol 2020;59:677-84.","DOI":"10.1111\/ijd.14767"},{"key":"19434","doi-asserted-by":"crossref","unstructured":"Kwiatkowski S, Knap B, Przystupski D, et al. Photodynamic therapy - mechanisms, photosensitizers and combinations. Biomed Pharmacother 2018;106:1098-107.","DOI":"10.1016\/j.biopha.2018.07.049"},{"key":"19435","doi-asserted-by":"crossref","unstructured":"Yoo JO, Ha KS. New insights into the mechanisms for photodynamic therapy-induced cancer cell death. Int Rev Cell Mol Biol 2012;295:139-74.","DOI":"10.1016\/B978-0-12-394306-4.00010-1"},{"key":"19436","doi-asserted-by":"crossref","unstructured":"Szeim\u00efes RM. Pain perception during photodynamic therapy: why is daylight PDT with methyl aminolevulinate almost pain-free? A review on the underlying mechanisms, clinical reflections and resulting opportunities. G Ital Dermatol Venereol 2018;153:793-9.","DOI":"10.23736\/S0392-0488.18.06011-X"},{"key":"19437","doi-asserted-by":"crossref","unstructured":"Bai-Habelski JC, Medrano K, Palacio A, Reinhold U. No room for pain: a prospective study showing effective and nearly pain-free treatment of actinic keratosis with simulated daylight photodynamic therapy (SDL-PDT) using the IndoorLux\u00ae System in combination with BF-200 ALA (Ameluz\u00ae). Photodiagnosis Photodyn Ther 2022;37:102692.","DOI":"10.1016\/j.pdpdt.2021.102692"},{"key":"19438","doi-asserted-by":"crossref","unstructured":"Rosenberg AR, Tabacchi M, Ngo KH, et al. Skin cancer precursor immunotherapy for squamous cell carcinoma prevention. JCI Insight 2019;4:e125476.","DOI":"10.1172\/jci.insight.125476"},{"key":"19439","doi-asserted-by":"crossref","unstructured":"Cunningham TJ, Tabacchi M, Eliane JP, et al. Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. J Clin Invest 2017;127:106-16.","DOI":"10.1172\/JCI89820"},{"key":"19440","doi-asserted-by":"crossref","unstructured":"Torezan L, Grinblat B, Haedersdal M, et al. A randomized split-scalp study comparing calcipotriol-assisted methyl aminolaevulinate photodynamic therapy (MAL-PDT) with conventional MAL-PDT for the treatment of actinic keratosis. Br J Dermatol 2018;179:829-35.","DOI":"10.1111\/bjd.16473"},{"key":"19441","doi-asserted-by":"crossref","unstructured":"Corren J, Ziegler SF. TSLP: from allergy to cancer. Nat Immunol 2019;20:1603-9.","DOI":"10.1038\/s41590-019-0524-9"},{"key":"19442","unstructured":"Seckin D, Cerman AA, Yildiz A, Ergun T. Can topical calcipotriol be a treatment alternative in actinic keratoses? A preliminary report. J Drugs Dermatol 2009;8:451-4."}],"container-title":["Dermatology Reports"],"original-title":[],"link":[{"URL":"https:\/\/www.pagepress.org\/journals\/dr\/article\/download\/10077\/9449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepress.org\/journals\/dr\/article\/download\/10077\/9449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T13:14:26Z","timestamp":1727788466000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pagepress.org\/journals\/dr\/article\/view\/10077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":14,"URL":"https:\/\/doi.org\/10.4081\/dr.2024.10077","relation":{},"ISSN":["2036-7406","2036-7392"],"issn-type":[{"type":"electronic","value":"2036-7406"},{"type":"print","value":"2036-7392"}],"subject":[],"published":{"date-parts":[[2024,10,1]]}}}