{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:46:27Z","timestamp":1791830787735,"version":"4.3.4"},"reference-count":19,"publisher":"PAGEPress Publications","issue":"3","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Several fruits have been identified as allergens and potential triggers for exacerbation of atopic dermatitis (AD). This study evaluated pineapple allergy and sensitization among adult patients with AD and examined the diagnostic accuracy of a locally produced pineapple allergen extract in skin prick tests (SPTs). A total of 30 adult patients with AD, with a mean age of 36.07\u00b110.81 years, were enrolled in the study. Firstly, SPT was performed using a standard pineapple allergen extract manufactured by Astromed\u00ae (Astromed Inc., West Warwick, Rhode Island, USA). Subsequently, a second SPT was carried out with the pineapple allergen extract produced by the Teaching Industry Allergen Dr. Soetomo General Academic Hospital, Universitas Airlangga (Surabaya, Indonesia). Data were analyzed for diagnostic test accuracy and agreement. The local pineapple SPT had a sensitivity of 33.33% and a specificity of 100%. The test exhibited a positive predictive value (PPV) of 100%, whereas the negative predictive value (NPV) was 93.10%. The agreement between the standard SPT and the local SPT was statistically significant, exhibiting moderate concordance (p=0.002). The Indonesian pineapple allergen extract for SPT can serve as an alternative diagnostic tool to assess pineapple allergy and sensitization in AD patients.<\/jats:p>","DOI":"10.4081\/dr.2025.10004","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T07:19:11Z","timestamp":1760080751000},"source":"Crossref","is-referenced-by-count":0,"title":["Indonesian pineapple allergen extract for skin prick test as an alternative diagnostic tool in atopic dermatitis"],"prefix":"10.4081","volume":"18","author":[{"given":"Cita Rosita Sigit","family":"Prakoeswa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damayanti","family":"Damayanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Anggraeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menul Ayu","family":"Umborowati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mochammad Ayyub","family":"Arachman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trisniartami","family":"Setyaningrum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"43972","doi-asserted-by":"crossref","unstructured":"1. Papapostolou N, Xepapadaki P, Gregoriou S, Makris M. Atopic Dermatitis and Food Allergy: A Complex Interplay. What We Know and What We Would Like to Learn. J Clin Med 2022;11.","DOI":"10.3390\/jcm11144232"},{"key":"43973","unstructured":"2. Rismauli NF, Barakbah J. Retrospective Study of Skin Prick Test in Atopic Dermatitis Patients at DermatoVenereology Outpatient Clinic of Dr. Soetomo General Hospital Surabaya During 2007-2012. Berkala Ilmu Kesehatan Kulit dan Kelamin 2016;27:9-16."},{"key":"43974","doi-asserted-by":"crossref","unstructured":"3. Dom\u00ednguez O, Plaza AM, Alvaro M. Relationship Between Atopic Dermatitis and Food Allergy. Curr Pediatr Rev 2020;16:115-22.","DOI":"10.2174\/157339631566619111112243"},{"key":"43975","doi-asserted-by":"crossref","unstructured":"4. Ansotegui IJ, Melioli G, Canonica GW, et al. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper. World Allergy Organ J 2020;13:100080.","DOI":"10.1016\/j.waojou.2019.100080"},{"key":"43976","doi-asserted-by":"crossref","unstructured":"5. Chang LS, Chang HY, Yang YH, et al. Allergen Tests of Fruit Sensitization Involving Children with Allergic Diseases. Children 2022;9:470.","DOI":"10.3390\/children9040470"},{"key":"43977","doi-asserted-by":"crossref","unstructured":"6. Thongkhom R, Oncham S, Sompornrattanaphan M, Laisuan W. Banana anaphylaxis in Thailand: case series. Asia Pac Allergy 2020;10:e4.","DOI":"10.5415\/apallergy.2020.10.e4"},{"key":"43978","doi-asserted-by":"crossref","unstructured":"7. Zuidmeer L, Goldhahn K, Rona RJ, et al. The prevalence of plant food allergies: A systematic review. J Allergy Clin Immunol 2008;121:1210-8.e4.","DOI":"10.1016\/j.jaci.2008.02.019"},{"key":"43979","doi-asserted-by":"crossref","unstructured":"8. Liang J, Xu J, Pan J, et al. Identification of the Main Allergenic Proteins in High Hydrostatic Pressure Pineapple Juice and Assessing the Influence of Pressure on their Allergenicity. Int J Food Prop 2015;18:2134-44.","DOI":"10.1080\/10942912.2014.966386"},{"key":"43980","doi-asserted-by":"crossref","unstructured":"9. Bignardi D, Comite P, Mori I, et al. Allergen-specific IgE: comparison between skin prick test and serum assay in real life. Allergol Select 2019;3:9-14.","DOI":"10.5414\/ALX01891E"},{"key":"43981","unstructured":"10. Ismayani. Hubungan Gejala Klinis dengan Hasil Tes Cukit Kulit pada Pasien dengan Rinitis Alergi di RSUP H. Adam Malik Medan [The Relationship Between Clinical Symptoms and Skin Prick Test Results in Patients with Allergic Rhinitis at H. Adam Malik General Hospital, Medan]. Universitas Sumatera Utara; 2017."},{"key":"43982","doi-asserted-by":"crossref","unstructured":"11. Nopriyati N, Antonius CS, Thaha HMA, et al. Skin Prick Test Profile: A Retrospective Study. Berkala Ilmu Kesehatan Kulit dan Kelamin 2022;34:189-96.","DOI":"10.20473\/bikk.V34.3.2022.189-196"},{"key":"43983","doi-asserted-by":"crossref","unstructured":"12. Munthaha MIA, Widayati RI, Afriliana L, Candra A. Characteristics of Atopic Dermatitis in Puskesmas (Public Health Center) Masaran 1 Sragen Regency. Diponegoro Med J 2021;10:27-34.","DOI":"10.14710\/dmj.v10i1.29557"},{"key":"43984","doi-asserted-by":"crossref","unstructured":"13. Leffler J, Stumbles P, Strickland D. Immunological Processes Driving IgE Sensitisation and Disease Development in Males and Females. Int J Mol Sci 2018;19:1554.","DOI":"10.3390\/ijms19061554"},{"key":"43985","doi-asserted-by":"crossref","unstructured":"14. Nugroho WT, Ervianti E, Zulkarnain I, et al. Characteristics of Atopic Dermatitis Patients who Underwent Skin Prick Test. Berkala Ilmu Kesehatan Kulit dan Kelamin 2022;34:10-4.","DOI":"10.20473\/bikk.V34.1.2022.10-14"},{"key":"43986","unstructured":"15. Anggraeni S, Umborowati MAD, Endaryanto A, Prakoeswa CRS. Correlation between Skin Prick Test and Specific IgE of Local Mites Allergen in Atopic Dermatitis Patients: an Indonesian Study. CMUJ Nat Sci 2022;21."},{"key":"43987","doi-asserted-by":"crossref","unstructured":"16. Terlouw S, van Boven FE, Borsboom-van Zonneveld M, et al. Homemade Food Allergen Extracts for Use in Skin Prick Tests in the Diagnosis of IgE-Mediated Food Allergy: A Good Alternative in the Absence of Commercially Available Extracts? Nutrients 2022;14:475.","DOI":"10.3390\/nu14030475"},{"key":"43988","unstructured":"17. Lubis A, Barlianto W, Endaryanto A, Harsono A. Compatibility of Clinical Manifestation with Skin Prick Test Result and Food Provocation Test in Food Cross Reaction. Berkala Ilmu Kesehatan Kulit Dan Kelamin 2017;29:106-16."},{"key":"43989","doi-asserted-by":"crossref","unstructured":"18. Gupta M, Cox A, Nowak-W\u0119grzyn A, Wang J. Diagnosis of Food Allergy. Immunol Allergy Clin North Am 2018;38:39-52.","DOI":"10.1016\/j.iac.2017.09.004"},{"key":"43990","doi-asserted-by":"crossref","unstructured":"19. Anggraeni S, Prakoeswa CRS, Endaryanto A, et al. The Accuracy of Indonesian New Local Skin Prick Test (SPT) Allergen Extracts as Diagnostic Tool of IgE-mediated Atopic Dermatitis. Indian J Forensic Med Toxicol 2021;15.","DOI":"10.37506\/ijfmt.v15i3.15965"}],"container-title":["Dermatology Reports"],"original-title":[],"link":[{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10004\/9768","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10004\/10111","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10004\/9768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:02:41Z","timestamp":1791828161000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/view\/10004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,10]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.4081\/dr.2025.10004","relation":{},"ISSN":["2036-7406","2036-7392"],"issn-type":[{"value":"2036-7406","type":"electronic"},{"value":"2036-7392","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,10]]}}}